AbstractPurpose: Orthopaedic surgery patients are at an elevated risk of venous thromboembolic events thus necessitating effective prophylaxis strategies.Methods: This IRB-approved, single-center retrospective study evaluated patients who underwent orthopaedic surgery and were protected with Inferior Vena Cava (IVC) filters from January 2007 to December 2021. Study outcomes include incidence of venous thromboembolism (VTE) in the form… Continue reading Clinical outcomes of #orthopaedic surgery patients with inferior vena #cava filter prophylaxis
Tag: Thrombosis
#Erythrocytosis and #thromboembolic risks associated with #SGLT2 inhibitors in type 2 diabetes
This study aimed to determine if sodium-glucose co-transporter-2 inhibitors (SGLT2i) use in diabetic patients leads to erythrocytosis and increases the incidence of arterial and venous thrombosis events. This is a retrospective cohort study using records from over 50 U.S. healthcare organizations. Adults with type 2 diabetes who received SGLT2i therapy were compared to those on… Continue reading #Erythrocytosis and #thromboembolic risks associated with #SGLT2 inhibitors in type 2 diabetes
#Thromboembolic events and vascular #dementia in patients with atrial #fibrillation and low apparent stroke risk
The prevention of thromboembolism in atrial fibrillation (AF) is typically restricted to patients with specific risk factors and ignores outcomes such as vascular dementia. This population-based cohort study used electronic healthcare records from 5,199,994 primary care patients (UK; 2005–2020). A total of 290,525 (5.6%) had a diagnosis of AF and were aged 40–75 years, of… Continue reading #Thromboembolic events and vascular #dementia in patients with atrial #fibrillation and low apparent stroke risk
#Statin Use and the Risk of Venous #Thromboembolism in Women Taking #Hormone Therapy
Although hormone therapy (HT) in perimenopausal women is associated with increased risk for venous thromboembolism (VTE), it is unclear to what extent statins may mitigate this HT-associated risk.Objective To estimate VTE risk in women aged 50 to 64 years taking HT with or without statins.Design, Setting, and Participants This nested case-control study analyzed data from a commercially… Continue reading #Statin Use and the Risk of Venous #Thromboembolism in Women Taking #Hormone Therapy
Smart thrombosis inhibitors without bleeding side effects via charge tunable ligand design
Current treatments to prevent thrombosis, namely anticoagulants and platelets antagonists, remain complicated by the persistent risk of bleeding. Improved therapeutic strategies that diminish this risk would have a huge clinical impact. Antithrombotic agents that neutralize and inhibit polyphosphate (polyP) can be a powerful approach towards such a goal. Here, we report a design concept towards… Continue reading Smart thrombosis inhibitors without bleeding side effects via charge tunable ligand design
SCAI/HRS Expert Consensus Statement on Transcatheter Left Atrial Appendage Closure
Exclusion of the left atrial appendage to reduce thromboembolic risk related to atrial fibrillation was first performed surgically in 1949. Over the past 2 decades, the field of transcatheter endovascular left atrial appendage closure (LAAC) has rapidly expanded, with a myriad of devices approved or in clinical development. The number of LAAC procedures performed in… Continue reading SCAI/HRS Expert Consensus Statement on Transcatheter Left Atrial Appendage Closure
The artificial sweetener erythritol and cardiovascular event risk
Artificial sweeteners are widely used sugar substitutes, but little is known about their long-term effects on cardiometabolic disease risks. Here we examined the commonly used sugar substitute erythritol and atherothrombotic disease risk. In initial untargeted metabolomics studies in patients undergoing cardiac risk assessment (n = 1,157; discovery cohort, NCT00590200), circulating levels of multiple polyol sweeteners, especially erythritol,… Continue reading The artificial sweetener erythritol and cardiovascular event risk
Acute ischemic stroke and vaccine-induced immune thrombotic thrombocytopenia post COVID-19 vaccination; a systematic review
AbstractIntroductionOne of the rare but potentially serious side effects of COVID-19 vaccination is arterial and venous thrombosis. Acute ischemic stroke (AIS) cases have been reported post COVID-19 vaccination. Herein, we systematically reviewed the reported cases of AIS after COVID-19 vaccination.MethodThis systematic review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses… Continue reading Acute ischemic stroke and vaccine-induced immune thrombotic thrombocytopenia post COVID-19 vaccination; a systematic review
A Three-Case Series of Thrombotic Deaths in Patients over 50 with Comorbidities Temporally after modRNA COVID-19 Vaccination
Coronavirus disease 2019 (COVID-19) is the most dramatic pandemic of the new millennium; to counteract it, specific vaccines have been launched in record time under emergency use authorization or conditional marketing authorization by virtue of a favorable risk/benefit balance. Among the various technological platforms, there is that exploiting a nucleoside-modified messenger RNA (modRNA), such as… Continue reading A Three-Case Series of Thrombotic Deaths in Patients over 50 with Comorbidities Temporally after modRNA COVID-19 Vaccination
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