Earlier administration of intravenous tissue plasminogen activator (tPA) in acute ischemic stroke is associated with reduced mortality by the time of hospital discharge and better functional outcomes at 3 months. However, it remains unclear whether shorter door-to-needle times translate into better long-term outcomes.. ..Among the 61 426 patients treated with tPA within 4.5 hours, the median… Continue reading Association Between Thrombolytic Door-to-Needle Time and 1-Year Mortality and Readmission in Patients With Acute Ischemic #Stroke
Tag: stroke
Complement-Dependent Synaptic Uptake and Cognitive Decline after #Stroke and Reperfusion Therapy
..This study addresses two major challenges facing the treatment of stroke in the era of reperfusion therapy: hemorrhagic transformation and the disconnect between successful revascularization and functional outcomes. We studied how complement-dependent neuroinflammation drives the pathophysiology behind these challenges using a translationally relevant strategy. Complement inhibition was achieved using B4Crry, an injury site-targeted inhibitor of… Continue reading Complement-Dependent Synaptic Uptake and Cognitive Decline after #Stroke and Reperfusion Therapy
#Vegetarian diet and incidence of total, ischemic, and hemorrhagic #stroke in 2 cohorts in Taiwan
To determine how a vegetarian diet affects stroke incidence in 2 prospective cohorts and to explore whether the association is modified by dietary vitamin B12 intake.. ..Vegetarians had lower serum vitamin B12 and higher folate and homocysteine than nonvegetarians. In cohort 1, 54 events occurred in 30,797 person-years follow-up. Vegetarians (vs nonvegetarians) experienced lower risk… Continue reading #Vegetarian diet and incidence of total, ischemic, and hemorrhagic #stroke in 2 cohorts in Taiwan
The associations of major #foods and fibre with risks of ischaemic and haemorrhagic #stroke: a prospective study of 418 329 participants in the EPIC cohort across nine European countries
..For ischaemic stroke (4281 cases), lower risks were observed with higher consumption of fruit and vegetables combined (HR; 95% CI per 200 g/day higher intake, 0.87; 0.82–0.93, P-trend < 0.001), dietary fibre (per 10 g/day, 0.77; 0.69–0.86, P-trend < 0.001), milk (per 200 g/day, 0.95; 0.91–0.99, P-trend = 0.02), yogurt (per 100 g/day, 0.91; 0.85–0.97, P-trend = 0.004), and cheese (per 30 g/day, 0.88; 0.81–0.97, P-trend = 0.008), while higher… Continue reading The associations of major #foods and fibre with risks of ischaemic and haemorrhagic #stroke: a prospective study of 418 329 participants in the EPIC cohort across nine European countries
Five-Year Outcomes of Transcatheter or Surgical #Aortic-Valve Replacement
..At 5 years, there was no significant difference in the incidence of death from any cause or disabling stroke between the TAVR group and the surgery group (47.9% and 43.4%, respectively; hazard ratio, 1.09; 95% confidence interval [CI], 0.95 to 1.25; P=0.21). Results were similar for the transfemoral-access cohort (44.5% and 42.0%, respectively; hazard ratio,… Continue reading Five-Year Outcomes of Transcatheter or Surgical #Aortic-Valve Replacement
Estimated #Stroke-Free Survival of #Folic Acid Therapy for Hypertensive Adults
The CSPPT (China Stroke Primary Prevention Trial) demonstrated a significant risk reduction of first stroke in hypertensive patients treated with enalapril plus folic acid compared with those with enalapril alone, but the lifetime stroke-free survival associated with the treatment is unknown.. ..Compared with enalapril alone, the enalapril plus folic acid treatment projected a mean lifetime… Continue reading Estimated #Stroke-Free Survival of #Folic Acid Therapy for Hypertensive Adults
Association between ambient fine #particulate pollution and hospital admissions for cause specific #cardiovascular disease: time series study in 184 major Chinese cities
..At the national average level, an increase of 10 μg/m3 in PM2.5 was associated with a 0.26% (95% confidence interval 0.17% to 0.35%) increase in hospital admissions on the same day for cardiovascular disease, 0.31% (0.22% to 0.40%) for ischaemic heart disease, 0.27% (0.04% to 0.51%) for heart failure, 0.29% (0.12% to 0.46%) for heart… Continue reading Association between ambient fine #particulate pollution and hospital admissions for cause specific #cardiovascular disease: time series study in 184 major Chinese cities
Does type 2 #diabetes confer higher relative rates of #cardiovascular events in women compared with men?
..calculate overall and age-dependent incidence rates, incidence rate ratios, and women-to-men ratios for myocardial infarction, heart failure, ischaemic stroke, or cardiovascular death (MACE-HF). Among 218 549 (46% women) individuals with diabetes, the absolute rate of MACE-HF was higher in men than in women (24.9 vs. 19.9 per 1000 person-years). Corresponding absolute rates in men and… Continue reading Does type 2 #diabetes confer higher relative rates of #cardiovascular events in women compared with men?
#Hemoglobin concentration and risk of arterial and venous #thrombosis in 1.5 million Swedish and Danish blood donors
..The risk of myocardial infarction and ischemic stroke increased with higher hemoglobin concentration in both men and women. The HRs for myocardial infarction and ischemic stroke in men with hemoglobin concentration ≥ 17.5 g/dL were 3.52 (95% confidence interval [CI], 2.85–4.36) and 2.36 (95% CI, 1.63–3.43), respectively, compared to the reference group. The corresponding HRs for women with… Continue reading #Hemoglobin concentration and risk of arterial and venous #thrombosis in 1.5 million Swedish and Danish blood donors
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