It is known that some people age faster than others, some people live into old age disease-free, while others develop age-related chronic diseases. With a rapidly aging population and an emerging chronic diseases epidemic, finding mechanisms and implementing preventive measures that could slow down the aging process has become a new challenge for biomedical research… Continue reading Middle-age high normal serum sodium as a risk factor for accelerated biological aging, chronic diseases, and premature mortality
Tag: sodium
Sodium accumulation in breast cancer predicts malignancy and treatment response
BackgroundBreast cancer remains a leading cause of death in women and novel imaging biomarkers are urgently required. Here, we demonstrate the diagnostic and treatment-monitoring potential of non-invasive sodium (23Na) MRI in preclinical models of breast cancer. MethodsFemale Rag2−/− Il2rg−/− and Balb/c mice bearing orthotopic breast tumours (MDA-MB-231, EMT6 and 4T1) underwent MRI as part of… Continue reading Sodium accumulation in breast cancer predicts malignancy and treatment response
Reduction of dietary sodium to less than 100 mmol in heart failure (SODIUM-HF): an international, open-label, randomised, controlled trial
BackgroundDietary restriction of sodium has been suggested to prevent fluid overload and adverse outcomes for patients with heart failure. We designed the Study of Dietary Intervention under 100 mmol in Heart Failure (SODIUM-HF) to test whether or not a reduction in dietary sodium reduces the incidence of future clinical events. MethodsSODIUM-HF is an international, open-label,… Continue reading Reduction of dietary sodium to less than 100 mmol in heart failure (SODIUM-HF): an international, open-label, randomised, controlled trial
Sodium-containing acetaminophen and cardiovascular outcomes in individuals with and without hypertension
AimsPrevious studies have found high sodium intake to be associated with increased risks of cardiovascular disease (CVD) and all-cause mortality among individuals with hypertension; findings on the effect of intake among individuals without hypertension have been equivocal. We aimed to compare the risks of incident CVD and all-cause mortality among initiators of sodium-containing acetaminophen with… Continue reading Sodium-containing acetaminophen and cardiovascular outcomes in individuals with and without hypertension
Effect of dose and duration of reduction in dietary #sodium on blood #pressure levels: systematic review and meta-analysis of randomised trials
... Each 50 mmol reduction in 24 hour sodium excretion was associated with a 1.10 mm Hg (0.66 to 1.54; P<0.001) reduction in SBP and a 0.33 mm Hg (0.04 to 0.63; P=0.03) reduction in DBP. Reductions in blood pressure were observed in diverse population subsets examined, including hypertensive and non-hypertensive individuals. For the same… Continue reading Effect of dose and duration of reduction in dietary #sodium on blood #pressure levels: systematic review and meta-analysis of randomised trials
Dietary #Potassium Intake Remains Low and #Sodium Intake Remains High, and Most Sodium is Derived from Home Food Preparation for Chinese Adults, 1991–2015 Trends
..Sodium intake decreased from 6.3 g/d in 1991 to 4.1 g/d in 2015, still twice the tolerable upper intake recommended by the WHO. Potassium intake was 1.7 g/d in 1991 and 1.5 g/d in 2015, below half that recommended by the WHO. The Na/K ratio decreased from 4.1 (ratios in g) in 1991 to 3.1… Continue reading Dietary #Potassium Intake Remains Low and #Sodium Intake Remains High, and Most Sodium is Derived from Home Food Preparation for Chinese Adults, 1991–2015 Trends
Drinking Water #Salinity, Urinary Macro‐Mineral Excretions, and Blood #Pressure in the Southwest Coastal Population of Bangladesh
Sodium (Na+) in saline water may increase blood pressure (BP), but potassium (K+), calcium (Ca2+), and magnesium (Mg2+) may lower BP. We assessed the association between drinking water salinity and population BP.. ..fresh water (electrical conductivity, <0.7 mS/cm), mild salinity (electrical conductivity ≥0.7 and <2 mS/cm), and moderate salinity (electrical conductivity ≥2 and <10 mS/cm)..… Continue reading Drinking Water #Salinity, Urinary Macro‐Mineral Excretions, and Blood #Pressure in the Southwest Coastal Population of Bangladesh
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