Tag: Pain

Neural Signatures of Pain Modulation in Short-Term and Long-Term Mindfulness Training: A Randomized Active-Control Trial

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Mindfulness-based interventions are widely used to target pain, yet their neural mechanisms of action are insufficiently understood. The authors studied neural and subjective pain response in a randomized active-control trial of mindfulness-based stress reduction (MBSR) alongside long-term meditation practitioners.Methods:Healthy participants (N=115) underwent functional neuroimaging during a thermal acute pain task before and after random assignment… Continue reading Neural Signatures of Pain Modulation in Short-Term and Long-Term Mindfulness Training: A Randomized Active-Control Trial

Disentangling self from pain: mindfulness meditation-induced pain relief is driven by thalamic-default mode network decoupling

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For millenniums, mindfulness was thought to diminish pain by reducing the influence of self-appraisals of noxious sensations. Today, mindfulness meditation is a highly popular and effective pain therapy that is thought to engage multiple, non-placebo related mechanisms to attenuate pain. Recent evidence suggests that mindfulness meditation-induced pain relief is associated with the engagement of unique… Continue reading Disentangling self from pain: mindfulness meditation-induced pain relief is driven by thalamic-default mode network decoupling

Early life inflammation is associated with spinal cord excitability and nociceptive sensitivity in human infants

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Immune function and sensitivity to pain are closely related, but the association between early life inflammation and sensory nervous system development is poorly understood—especially in humans. Here, in term-born infants, we measure brain activity and reflex withdrawal activity (using EEG and EMG) and behavioural and physiological activity (using the PIPP-R score) to assess the impact… Continue reading Early life inflammation is associated with spinal cord excitability and nociceptive sensitivity in human infants

Behavioral and inflammatory sex differences revealed by celecoxib nanotherapeutic treatment of peripheral neuroinflammation

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Neuropathic pain affects millions of people worldwide, yet the molecular mechanisms of how it develops and persists are poorly understood. Given that males have historically been utilized as the primary sex in preclinical studies, less is known about the female neuroinflammatory response to injury, formation of pain, or response to pain-relieving therapies. Macrophages contribute to… Continue reading Behavioral and inflammatory sex differences revealed by celecoxib nanotherapeutic treatment of peripheral neuroinflammation

Pain sensitivity is associated with general attitudes towards pain: Development and validation of a new instrument for pain research and clinical application

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With regard to attitudes towards pain, many questionnaires have been developed. Although undoubtedly useful, they were specifically designed for the use in chronic pain and are less suitable for the assessment in the general population. The purpose of the present paper was to develop a measure for the assessment of general attitudes towards pain applicable… Continue reading Pain sensitivity is associated with general attitudes towards pain: Development and validation of a new instrument for pain research and clinical application

Chronic pain precedes disrupted eating behavior in low-back pain patients

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Chronic pain is associated with anhedonia and decreased motivation. These behavioral alterations have been linked to alterations in the limbic brain and could explain the increased risk for obesity in pain patients. The mechanism of these behavioral changes and how they set in in relation to the development of chronic pain remain however poorly understood.… Continue reading Chronic pain precedes disrupted eating behavior in low-back pain patients

Pilot randomized controlled trial of a #hypnosis intervention for women with #bladder pain syndrome

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To evaluate the feasibility and acceptability of a randomized controlled trial of a hypnosis intervention for the treatment of bladder pain syndrome/interstitial cystitis (BPS/IC) in women. MethodsWe conducted a parallel arm, non-blinded, pilot randomized controlled trial of standardized hypnosis sessions including a hypnosis web tool versus usual care in adult women with BPS/IC. Pilot study… Continue reading Pilot randomized controlled trial of a #hypnosis intervention for women with #bladder pain syndrome

Effectiveness of Electroacupuncture or Auricular #Acupuncture vs Usual Care for Chronic Musculoskeletal Pain Among #Cancer Survivors The PEACE Randomized Clinical Trial

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The opioid crisis creates challenges for cancer pain management. Acupuncture confers clinical benefits for chronic nonmalignant pain, but its effectiveness in cancer survivors remains uncertain. Objective To determine the effectiveness of electroacupuncture or auricular acupuncture for chronic musculoskeletal pain in cancer survivors. Design, Setting, and Participants The Personalized Electroacupuncture vs Auricular Acupuncture Comparativeness Effectiveness (PEACE)… Continue reading Effectiveness of Electroacupuncture or Auricular #Acupuncture vs Usual Care for Chronic Musculoskeletal Pain Among #Cancer Survivors The PEACE Randomized Clinical Trial