Gut microbiota composition is directly associated with response to immunotherapies in cancer. How the diet impacts the gut microbiota and downstream immune responses to cancer remains unclear. Here, we show that consumption of a common non-nutritive sweetener, sucralose, modifies microbiome composition, restricts T cell metabolism and function, and limits immunotherapy response in preclinical models of… Continue reading #Sucralose consumption ablates #cancer immunotherapy response through #microbiome disruption
Tag: microbiome
Oral #microbiome and nitric oxide biomarkers in older people with mild #cognitive impairment and APOE4 genotype
AbstractApolipoprotein E4 (APOE4) genotype and nitric oxide (NO) deficiency are risk factors for age-associated cognitive decline. The oral microbiome plays a critical role in maintaining NO bioavailability during aging. The aim of this study was to assess interactions between the oral microbiome, NO biomarkers, and cognitive function in 60 participants with mild cognitive impairment (MCI)… Continue reading Oral #microbiome and nitric oxide biomarkers in older people with mild #cognitive impairment and APOE4 genotype
Gut #microbiome signatures of vegan, vegetarian and omnivore diets and associated health outcomes across 21,561 individuals
As plant-based diets gain traction, interest in their impacts on the gut microbiome is growing. However, little is known about diet-pattern-specific metagenomic profiles across populations. Here we considered 21,561 individuals spanning 5 independent, multinational, human cohorts to map how differences in diet pattern (omnivore, vegetarian and vegan) are reflected in gut microbiomes. Microbial profiles distinguished… Continue reading Gut #microbiome signatures of vegan, vegetarian and omnivore diets and associated health outcomes across 21,561 individuals
#Coffee consumption is associated with intestinal #Lawsonibacter asaccharolyticus abundance and prevalence across multiple cohorts
Although diet is a substantial determinant of the human gut microbiome, the interplay between specific foods and microbial community structure remains poorly understood. Coffee is a habitually consumed beverage with established metabolic and health benefits. We previously found that coffee is, among >150 items, the food showing the highest correlation with microbiome components. Here we… Continue reading #Coffee consumption is associated with intestinal #Lawsonibacter asaccharolyticus abundance and prevalence across multiple cohorts
Dynamics of the gut #microbiome in individuals at risk of #rheumatoid arthritis: a cross-sectional and longitudinal observational study
Objectives This work aimed to resolve the conflicting reports on Prevotellaceae abundance in the development of rheumatoid arthritis (RA) and to observe structural, functional and temporal changes in the gut microbiome in RA progressors versus non-progressors.Methods Individuals at risk of RA were defined by the presence of anticyclic citrullinated protein (anti-CCP) antibodies and new musculoskeletal… Continue reading Dynamics of the gut #microbiome in individuals at risk of #rheumatoid arthritis: a cross-sectional and longitudinal observational study
Divergent age-associated and metabolism-associated gut #microbiome signatures modulate #cardiovascular disease risk
Insight into associations between the gut microbiome with metabolism and aging is crucial for tailoring interventions to promote healthy longevity. In a discovery cohort of 10,207 individuals aged 40–93 years, we used 21 metabolic parameters to classify individuals into five clusters, termed metabolic multimorbidity clusters (MCs), that represent different metabolic subphenotypes. Compared to the cluster classified… Continue reading Divergent age-associated and metabolism-associated gut #microbiome signatures modulate #cardiovascular disease risk
Gut #microbiome and metabolome profiling in Framingham heart study reveals #cholesterol-metabolizing bacteria
Multi-omic profiling in FHS reveals microbes and metabolites associated with CVD•Oscillibacter species are associated with decreased blood and stool cholesterol•Homology searches and molecular networking predict cholesterol enzymes and products•Oscillibacter species encode for conserved cholesterol-metabolizing enzymesSummaryAccumulating evidence suggests that cardiovascular disease (CVD) is associated with an altered gut microbiome. Our understanding of the underlying mechanisms has been hindered… Continue reading Gut #microbiome and metabolome profiling in Framingham heart study reveals #cholesterol-metabolizing bacteria
Effect of #gut #microbiome modulation on #muscle function and #cognition: the PROMOTe randomised controlled trial
Studies suggest that inducing gut microbiota changes may alter both muscle physiology and cognitive behaviour. Gut microbiota may play a role in both anabolic resistance of older muscle, and cognition. In this placebo controlled double blinded randomised controlled trial of 36 twin pairs (72 individuals), aged ≥60, each twin pair are block randomised to receive… Continue reading Effect of #gut #microbiome modulation on #muscle function and #cognition: the PROMOTe randomised controlled trial
Resistant #starch decreases intrahepatic #triglycerides in patients with #NAFLD via gut microbiome alterations
Non-alcoholic fatty liver disease (NAFLD) is a hepatic manifestation of metabolic dysfunction for which effective interventions are lacking. To investigate the effects of resistant starch (RS) as a microbiota-directed dietary supplement for NAFLD treatment, we coupled a 4-month randomized placebo-controlled clinical trial in individuals with NAFLD (ChiCTR-IOR-15007519) with metagenomics and metabolomics analysis. Relative to the… Continue reading Resistant #starch decreases intrahepatic #triglycerides in patients with #NAFLD via gut microbiome alterations
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