A 2017 meta-analysis of data from 25 randomised controlled trials (RCTs) of vitamin D supplementation for the prevention of acute respiratory infections (ARIs) revealed a protective effect of this intervention. We aimed to examine the link between vitamin D supplementation and prevention of ARIs in an updated meta-analysis. Methods For this systematic review and meta-analysis,… Continue reading Vitamin #D supplementation to prevent acute respiratory #infections: a systematic review and meta-analysis of aggregate data from randomised controlled trials
Tag: Infections
#Meningeal γδ T cells regulate #anxiety-like behavior via IL-17a signaling in neurons
Interleukin (IL)-17a has been highly conserved during evolution of the vertebrate immune system and widely studied in contexts of infection and autoimmunity. Studies suggest that IL-17a promotes behavioral changes in experimental models of autism and aggregation behavior in worms. Here, through a cellular and molecular characterization of meningeal γδ17 T cells, we defined the nearest… Continue reading #Meningeal γδ T cells regulate #anxiety-like behavior via IL-17a signaling in neurons
Risk for Serious #Infection With Low-Dose #Glucocorticoids in Patients With #Rheumatoid Arthritis
Low-dose glucocorticoids are frequently used for the management of rheumatoid arthritis (RA) and other chronic conditions, but the safety of long-term use remains uncertain.. ..Associations between glucocorticoid dose (none, ≤5 mg/d, >5 to 10 mg/d, and >10 mg/d) and hospitalized infection were evaluated using inverse probability–weighted analyses, with 1-year cumulative incidence predicted from weighted models.… Continue reading Risk for Serious #Infection With Low-Dose #Glucocorticoids in Patients With #Rheumatoid Arthritis
Co‐occurrence of #antibiotic, biocide, and heavy #metal resistance genes in bacteria from metal and radionuclide contaminated soils at the Savannah River Site
Contaminants such as heavy metals may contribute to the dissemination of antimicrobial resistance (AMR) by enriching resistance gene determinants via co‐selection mechanisms. In the present study, a survey was performed on soils collected from four areas at the Savannah River Site (SRS), South Carolina, USA, with varying contaminant profiles: relatively pristine (Upper Three Runs), heavy… Continue reading Co‐occurrence of #antibiotic, biocide, and heavy #metal resistance genes in bacteria from metal and radionuclide contaminated soils at the Savannah River Site
Effectiveness of #honey for symptomatic relief in upper #respiratory tract infections: a systematic review and meta-analysis
Antibiotic over prescription for upper respiratory tract infections (URTIs) in primary care exacerbates antimicrobial resistance. There is a need for effective alternatives to antibiotic prescribing. Honey is a lay remedy for URTIs, and has an emerging evidence base for its use. Honey has antimicrobial properties, and guidelines recommended honey for acute cough in children.. ..We… Continue reading Effectiveness of #honey for symptomatic relief in upper #respiratory tract infections: a systematic review and meta-analysis
Reducing #Antibiotic Prescribing in Primary Care for #Respiratory Illness
One-third of outpatient antibiotic prescriptions for pediatric acute respiratory tract infections (ARTIs) are inappropriate. We evaluated a distance learning program’s effectiveness for reducing outpatient antibiotic prescribing for ARTI visits.. In this stepped-wedge clinical trial run from November 2015 to June 2018, we randomly assigned 19 pediatric practices belonging to the Pediatric Research in Office Settings… Continue reading Reducing #Antibiotic Prescribing in Primary Care for #Respiratory Illness
Stress related disorders and subsequent risk of life threatening #infections: population based sibling controlled cohort study
..144 919 individuals with stress related disorders (post-traumatic stress disorder (PTSD), acute stress reaction, adjustment disorder, and other stress reactions) identified from 1987 to 2013 ..Stress related disorders were associated with all studied life threatening infections, with the highest relative risk observed for meningitis (sibling based analysis 1.63 (1.23 to 2.16)) and endocarditis (1.57 (1.08 to… Continue reading Stress related disorders and subsequent risk of life threatening #infections: population based sibling controlled cohort study
2 Medical News 