The treadmill exercise test with electrocardiogram (ECG), also known as an exercise stress test, is one of the most familiar tests in medicine. While exercise testing typically is focused on diagnosing coronary artery disease, a recent study from Mayo Clinic finds that exercise test abnormalities, such as low functional aerobic capacity, predicted non-cardiovascular causes of death such as… Continue reading Stress test abnormalities reveal more than just cardiovascular risks, Mayo Clinic study finds
Tag: heart
Warning symptoms associated with imminent sudden #cardiac arrest: a population-based case-control study with external validation
BackgroundSudden cardiac arrest is a global public health problem with a mortality rate of more than 90%. Prearrest warning symptoms could be harnessed using digital technology to potentially improve survival outcomes. We aimed to estimate the strength of association between symptoms and imminent sudden cardiac arrest.MethodsWe conducted a case-control study of individuals with sudden cardiac… Continue reading Warning symptoms associated with imminent sudden #cardiac arrest: a population-based case-control study with external validation
Antibody-Associated Reversal of ATTR Amyloidosis–Related Cardiomyopathy
The investigators describe antibodies that bound amyloid in three patients with transthyretin amyloidosis. Spontaneous regression of cardiomyopathy occurred in all three patients. https://www.nejm.org/doi/full/10.1056/NEJMc2304584
Straight from the heart
Lipids called ceramides may be better predictors of cardiovascular problems than cholesterol. Doctors and pharma are waking up to their potential https://www.science.org/content/article/straight-heart-mysterious-lipids-may-predict-cardiac-problems-better-cholesterol
Identification of astroglia-like cardiac nexus glia that are critical regulators of cardiac development and function
Glial cells are essential for functionality of the nervous system. Growing evidence underscores the importance of astrocytes; however, analogous astroglia in peripheral organs are poorly understood. Using confocal time-lapse imaging, fate mapping, and mutant genesis in a zebrafish model, we identify a neural crest–derived glial cell, termed nexus glia, which utilizes Meteorin signaling via Jak/Stat3… Continue reading Identification of astroglia-like cardiac nexus glia that are critical regulators of cardiac development and function
Compensatory ion transport buffers daily protein #rhythms to regulate osmotic balance and cellular physiology
Between 6–20% of the cellular proteome is under circadian control and tunes mammalian cell function with daily environmental cycles. For cell viability, and to maintain volume within narrow limits, the daily variation in osmotic potential exerted by changes in the soluble proteome must be counterbalanced. The mechanisms and consequences of this osmotic compensation have not… Continue reading Compensatory ion transport buffers daily protein #rhythms to regulate osmotic balance and cellular physiology
A Meta-Analysis on the Global Prevalence, Risk factors and Screening of Coronary #Heart Disease in Non-alcoholic #Fatty Liver Disease
Background and AimsCardiovascular disease remains the leading cause of death in patients with non-alcoholic fatty liver disease (NAFLD). Studies examining the association of coronary heart disease (CHD) and NAFLD are cofounded by various cardiometabolic factors particularly diabetes and body mass index. Hence, we seek to explore such association by investigating the global prevalence, independent risk… Continue reading A Meta-Analysis on the Global Prevalence, Risk factors and Screening of Coronary #Heart Disease in Non-alcoholic #Fatty Liver Disease
Prognostic and Practical Validation of ESC/EACTS High #Ischemic Risk Definition on Long-Term Thrombotic and Bleeding Events in Contemporary #PCI Patients
The ESC/EACTS myocardial revascularization guidelines recently standardized the definition of patients at high ischemic risk (HIR). However, the ability of ESC/EACTS-HIR criteria to stratify ischemic and bleeding risk in a contemporary real-world East Asian cohort remains unexplored. Methods: A total of 10,167 consecutive patients undergoing PCI from prospective Fuwai PCI Registry (January 2013 to December… Continue reading Prognostic and Practical Validation of ESC/EACTS High #Ischemic Risk Definition on Long-Term Thrombotic and Bleeding Events in Contemporary #PCI Patients
#Coronary heart disease in mothers and fathers of adult children with #alcohol use disorders
Having a family member with an alcohol use disorder (AUD) may negatively affect a person’s health. Our aim was to study the long-term risk of coronary heart disease (CHD) in parents who have an offspring with AUD. DesignCohort study. Cox regression models and co-sibling analyses. SettingSweden. ParticipantsFrom population registers, we selected all parent-offspring pairs in… Continue reading #Coronary heart disease in mothers and fathers of adult children with #alcohol use disorders
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