The majority of breast cancers are driven by oestrogen receptor-α (ERα) activation, and endocrine therapy represents the mainstay treatment for these patients1. However, resistance is common and tumours often progress after years of endocrine suppression2. Periodic fasting enhances the efficacy of standard endocrine therapy and delays acquired drug resistance, although the underlying mechanisms remain unclear3.… Continue reading #Fasting boosts #breast cancer therapy efficacy via glucocorticoid activation
Tag: fasting
The Effect of 4:3 Intermittent #Fasting on #Weight Loss at 12 Months: A Randomized Clinical Trial
AbstractBackground:Long-term (≥12 months) randomized trials evaluating the efficacy of intermittent fasting (IMF) as a dietary weight loss strategy are limited. Furthermore, no studies have compared IMF versus daily caloric restriction (DCR) when both interventions are provided in the context of a guidelines-based behavioral weight loss program.Objective:To compare the effects of 4:3 IMF versus DCR on… Continue reading The Effect of 4:3 Intermittent #Fasting on #Weight Loss at 12 Months: A Randomized Clinical Trial
Late #eating is associated with poor #glucose tolerance, independent of body weight, fat mass, energy intake and diet composition in prediabetes or early onset type 2 #diabetes
This study investigates the impact of habitual late calorie intake on glucose metabolism in adults with overweight or obesity and diet or metformin-controlled prediabetes or type 2 diabetes independently of body weight, fat mass, energy intake or diet composition. Participants (n = 26) were classified as Later Eaters (LE) if ≥45% daily calories were consumed after 5 pm… Continue reading Late #eating is associated with poor #glucose tolerance, independent of body weight, fat mass, energy intake and diet composition in prediabetes or early onset type 2 #diabetes
Brain responses to intermittent #fasting and the healthy living #diet in older adults
Highlights•8 weeks of 5:2 intermittent fasting caused more weight loss than healthy living diet•Both diets reduced neuronal insulin resistance and the pace of brain aging•Both diets improved memory and executive function, with 5:2 intermittent fasting more so•Biomarkers of Alzheimer’s disease did not change with either dietSummaryDiet may promote brain health in metabolically impaired older individuals. In… Continue reading Brain responses to intermittent #fasting and the healthy living #diet in older adults
#Fasting-mimicking #diet causes hepatic and blood markers changes indicating reduced biological #age and disease risk
In mice, periodic cycles of a fasting mimicking diet (FMD) protect normal cells while killing damaged cells including cancer and autoimmune cells, reduce inflammation, promote multi-system regeneration, and extend longevity. Here, we performed secondary and exploratory analysis of blood samples from a randomized clinical trial (NCT02158897) and show that 3 FMD cycles in adult study… Continue reading #Fasting-mimicking #diet causes hepatic and blood markers changes indicating reduced biological #age and disease risk
Monocytes re-enter the bone marrow during fasting and alter the host response to infection
Highlights •Circulating monocytes migrate to the bone marrow upon fasting•Monocytes augment CXCR4 via a fasting-induced hormonal stress response•Re-feeding after prolonged fasting results in a surge of monocytes into circulation•Prolonged fasting and re-feeding alter the immune response to bacterial infection SummaryDiet profoundly influences physiology. Whereas over-nutrition elevates risk for disease via its influence on immunity and… Continue reading Monocytes re-enter the bone marrow during fasting and alter the host response to infection
Intermittent fasting: is there a role in the treatment of diabetes? A review of the literature and guide for primary care physicians
Type 2 Diabetes is a metabolic disorder characterized by hyperglycemia that causes numerous complications with significant long-term morbidity and mortality. The disorder is primarily due to insulin resistance particularly in liver, skeletal muscle, and adipose tissue. In this review, we detail the hormonal mechanisms leading to the development of diabetes and discuss whether intermittent fasting… Continue reading Intermittent fasting: is there a role in the treatment of diabetes? A review of the literature and guide for primary care physicians
Acute #Liver Injury With Therapeutic Doses of #Acetaminophen: A Prospective Study
Because of the extensive use of this drug, further evaluation of acute liver injury (ALI) with therapeutic doses of acetaminophen (APAP; ≤6 g/d) is required. We characterize ALI with therapeutic doses of APAP and determine the host factors associated with disease severity and the predictors of outcome. Approach and Results All patients admitted with severe… Continue reading Acute #Liver Injury With Therapeutic Doses of #Acetaminophen: A Prospective Study
Blood #Pressure Changes in 1610 Subjects With and Without Antihypertensive Medication During Long‐Term #Fasting
We investigated daily blood pressure (BP) changes during fasting periods ranging from 4 to 41 (10.0±3.8) days in a cohort of 1610 subjects, including 920 normotensive, 313 hypertensive nonmedicated, and 377 hypertensive medicated individuals. Methods and Results Subjects underwent a multidisciplinary fasting program with a daily intake of ≈250 kcal. Weight and stress scores decreased… Continue reading Blood #Pressure Changes in 1610 Subjects With and Without Antihypertensive Medication During Long‐Term #Fasting
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