Highlights•Oats, brown rice, and millet improve health outcomes in diabetes mellitus type 2.•The most prevalent grains tested in trials included oats, brown rice, and buckwheat.•The most outcomes studied in diabetes were related to cardiovascular risk factors.AimsA systematic review and meta-analysis of published randomized controlled trials was conducted to collate evidence from studies implementing ancient grains… Continue reading Use of ancient #grains for the management of #diabetes mellitus: A systematic review and meta-analysis
Tag: Diabetes
Food #additive emulsifiers and the risk of type 2 #diabetes: analysis of data from the NutriNet-Santé prospective cohort study
Experimental studies have suggested potential detrimental effects of emulsifiers on gut microbiota, inflammation, and metabolic perturbations. We aimed to investigate the associations between exposures to food additive emulsifiers and the risk of type 2 diabetes in a large prospective cohort of French adults.MethodsWe analysed data from 104 139 adults enrolled in the French NutriNet-Santé prospective cohort… Continue reading Food #additive emulsifiers and the risk of type 2 #diabetes: analysis of data from the NutriNet-Santé prospective cohort study
Continuous #glucose monitoring and intrapersonal variability in fasting #glucose
Plasma fasting glucose (FG) levels play a pivotal role in the diagnosis of prediabetes and diabetes worldwide. Here we investigated FG values using continuous glucose monitoring (CGM) devices in nondiabetic adults aged 40–70 years. FG was measured during 59,565 morning windows of 8,315 individuals (7.16 ± 3.17 days per participant). Mean FG was 96.2 ± 12.87 mg dl−1, rising by 0.234 mg dl−1 per year with… Continue reading Continuous #glucose monitoring and intrapersonal variability in fasting #glucose
Summary: A new study explores the molecular connections between Type 2 #diabetes and #Alzheimer’s, supporting the notion of Alzheimer’s as “Type 3 diabetes.”
This study finds that a high-fat diet suppresses a crucial gut protein, Jak3, leading to Alzheimer’s-like brain changes in mice. It underscores the importance of managing diabetes or avoiding it through diet to reduce Alzheimer’s risk.The findings illuminate a potential path from diet through gut inflammation to brain health, offering hope for preventative strategies.Key Facts:Molecular… Continue reading Summary: A new study explores the molecular connections between Type 2 #diabetes and #Alzheimer’s, supporting the notion of Alzheimer’s as “Type 3 diabetes.”
30 – Early-Life #Tobacco Exposure, Genetic Risk, and Incident Type 2 #Diabetes
Tobacco exposure in adulthood is a well-established risk factor for type 2 diabetes (T2D), but how early-life tobacco exposure implicates in the development of T2D as well as whether this association varies by different genetic predisposition to T2D are unclear. Addressing these gaps may provide novel insights into early interventions of T2D.Hypothesis We hypothesized that tobacco… Continue reading 30 – Early-Life #Tobacco Exposure, Genetic Risk, and Incident Type 2 #Diabetes
Lac-Phe mediates the effects of #metformin on #food intake and body weight
Metformin is a widely prescribed anti-diabetic medicine that also reduces body weight. There is ongoing debate about the mechanisms that mediate metformin’s effects on energy balance. Here, we show that metformin is a powerful pharmacological inducer of the anorexigenic metabolite N-lactoyl-phenylalanine (Lac-Phe) in cells, in mice and two independent human cohorts. Metformin drives Lac-Phe biosynthesis through… Continue reading Lac-Phe mediates the effects of #metformin on #food intake and body weight
Effect of #Ergocalciferol on β-Cell Function in New-Onset Type 1 #Diabetes A Secondary Analysis of a Randomized Clinical Trial
IntroductionApproximately 30% to 50% residual β-cell function may remain at the time of type 1 diabetes (T1D) diagnosis, and this may persist for months or years.1,2 A prolonged partial remission (PR) phase of T1D leads to improved glycemic control and decreased long-term complications.1 We previously reported1 that ergocalciferol significantly decreased circulating tumor necrosis factor (TNF)-α and temporal trends… Continue reading Effect of #Ergocalciferol on β-Cell Function in New-Onset Type 1 #Diabetes A Secondary Analysis of a Randomized Clinical Trial
Association of #glycaemic index and glycaemic load with type 2 #diabetes, cardiovascular disease, cancer, and all-cause mortality: a meta-analysis of mega cohorts of more than 100 000 participants
BackgroundThere is debate over whether the glycaemic index of foods relates to chronic disease. We aimed to assess the associations between glycaemic index (GI) and glycaemic load (GL) and type 2 diabetes, cardiovascular disease, diabetes-related cancers, and all-cause mortality.MethodsWe did a meta-analysis of large cohorts (≥100 000 participants) identified from the Richard Doll Consortium. We searched… Continue reading Association of #glycaemic index and glycaemic load with type 2 #diabetes, cardiovascular disease, cancer, and all-cause mortality: a meta-analysis of mega cohorts of more than 100 000 participants
Association of #glycaemic index and glycaemic load with type 2 #diabetes, #cardiovascular disease, #cancer, and all-cause mortality: a meta-analysis of mega cohorts of more than 100 000 participants
There is debate over whether the glycaemic index of foods relates to chronic disease. We aimed to assess the associations between glycaemic index (GI) and glycaemic load (GL) and type 2 diabetes, cardiovascular disease, diabetes-related cancers, and all-cause mortality.MethodsWe did a meta-analysis of large cohorts (≥100 000 participants) identified from the Richard Doll Consortium. We searched… Continue reading Association of #glycaemic index and glycaemic load with type 2 #diabetes, #cardiovascular disease, #cancer, and all-cause mortality: a meta-analysis of mega cohorts of more than 100 000 participants
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