Aims/hypothesisIn our modern society, artificial light is available around the clock and most people expose themselves to electrical light and light-emissive screens during the dark period of the natural light/dark cycle. Such suboptimal lighting conditions have been associated with adverse metabolic effects, and redesigning indoor lighting conditions to mimic the natural light/dark cycle more closely… Continue reading The influence of bright and dim light on substrate metabolism, energy expenditure and thermoregulation in insulin-resistant individuals depends on time of day
Tag: Diabetes
Comprehensive investigations revealed consistent pathophysiological alterations after vaccination with COVID-19 vaccines
Large-scale COVID-19 vaccinations are currently underway in many countries in response to the COVID-19 pandemic. Here, we report, besides generation of neutralizing antibodies, consistent alterations in hemoglobin A1c, serum sodium and potassium levels, coagulation profiles, and renal functions in healthy volunteers after vaccination with an inactivated SARS-CoV-2 vaccine. Similar changes had also been reported in… Continue reading Comprehensive investigations revealed consistent pathophysiological alterations after vaccination with COVID-19 vaccines
Be Alert to the Risk of Adverse Cardiovascular Events after COVID-19 Vaccination
AbstractWith the global popularization of vaccination against coronavirus disease 2019 (COVID-19), the reports of cases of vaccine-related adverse events are increasing gradually. The most common events are local pain at the injection site and atypical symptoms, such as fever, headache, myalgia, and general discomfort. However, a few people might develop serious cardiovascular complications, such as… Continue reading Be Alert to the Risk of Adverse Cardiovascular Events after COVID-19 Vaccination
Dulaglutide and Incident Atrial Fibrillation or Flutter in patients with type 2 Diabetes; a post-hoc analysis from the REWIND Randomized Trial
Diabetes mellitus is an independent risk factor for atrial fibrillation or atrial flutter (atrial arrythmia, AA). Additionally, some diabetes medications may influence AA incidence. The aim of this post hoc analysis was to assess the occurrence of AA during the study period in patients with type 2 diabetes treated with once weekly subcutaneous dulaglutide vs… Continue reading Dulaglutide and Incident Atrial Fibrillation or Flutter in patients with type 2 Diabetes; a post-hoc analysis from the REWIND Randomized Trial
FGF1 and insulin control lipolysis by convergent pathways
Highlights•FGF1-FGFR1 signaling suppresses adipose lipolysis to curb hepatic glucose production•FGF1 suppresses lipolysis by inhibiting cAMP/PKA axis via PDE4D-S44 phosphorylation•Overexpression of PDE4D in the adipose tissue of diabetic mice corrects hyperglycemia•FGF1/PDE4D antilipolytic pathway is responsive to fed/fast states SummaryInexorable increases in insulin resistance, lipolysis, and hepatic glucose production (HGP) are hallmarks of type 2 diabetes. Previously,… Continue reading FGF1 and insulin control lipolysis by convergent pathways
Intermittent fasting: is there a role in the treatment of diabetes? A review of the literature and guide for primary care physicians
Type 2 Diabetes is a metabolic disorder characterized by hyperglycemia that causes numerous complications with significant long-term morbidity and mortality. The disorder is primarily due to insulin resistance particularly in liver, skeletal muscle, and adipose tissue. In this review, we detail the hormonal mechanisms leading to the development of diabetes and discuss whether intermittent fasting… Continue reading Intermittent fasting: is there a role in the treatment of diabetes? A review of the literature and guide for primary care physicians
Cytokine signature for predicting new-onset prediabetes after acute pancreatitis: A prospective longitudinal cohort study
Highlights•Interleukin-1β at baseline predicts new-onset prediabetes after acute pancreatitis. •Interferon γ at baseline predicts new-onset prediabetes after pancreatitis. •Changes in adaptive immunity may underlie glucose derangements after pancreatitis. AbstractBackground/purposeAcute inflammation of the pancreas often leads to metabolic sequelae, the most common of which is new-onset prediabetes (and, ultimately, diabetes). However, there is a lack of… Continue reading Cytokine signature for predicting new-onset prediabetes after acute pancreatitis: A prospective longitudinal cohort study
The 3p21.31 genetic locus promotes progression to type 1 diabetes through the CCR2/CCL2 pathway
•Serum CCL-2 levels are lower in individuals with islet autoantibodies and type 1 diabetes compared to controls. •The 3p21.31 genetic locus is associated with type 1 diabetes. •Serum CCL-2 levels are associated with the 3p21.31 genetic locus. •The 3p21.31 genetic locus is associated with gene expression of the CCL-2 receptor, CCR2. AbstractMultiple cross-sectional and longitudinal… Continue reading The 3p21.31 genetic locus promotes progression to type 1 diabetes through the CCR2/CCL2 pathway
Downregulation of Erythrocyte miR-210 Induces #Endothelial Dysfunction in Type 2 #Diabetes
Red blood cells (RBCs) act as mediators of vascular injury in type 2 diabetes mellitus (T2DM). miR-210 plays a protective role in cardiovascular homeostasis and is decreased in whole blood of T2DM mice. We hypothesized that downregulation of RBC miR-210 induces endothelial dysfunction in T2DM. RBCs were co-incubated with arteries and endothelial cells ex vivo… Continue reading Downregulation of Erythrocyte miR-210 Induces #Endothelial Dysfunction in Type 2 #Diabetes
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