Psilocybin may have antidepressant properties, but direct comparisons between psilocybin and established treatments for depression are lacking. METHODS In a phase 2, double-blind, randomized, controlled trial involving patients with long-standing, moderate-to-severe major depressive disorder, we compared psilocybin with escitalopram, a selective serotonin-reuptake inhibitor, over a 6-week period. Patients were assigned in a 1:1 ratio to… Continue reading Trial of #Psilocybin versus #Escitalopram for Depression
Tag: depression
Acute cognitive effects of single-dose intravenous #ketamine in major #depressive and posttraumatic stress disorder
Intravenous (IV) subanesthetic doses of ketamine have been shown to reduce psychiatric distress in both major depressive (MDD) and posttraumatic stress disorder (PTSD). However, the effect of ketamine on cognitive function in these disorders is not well understood. To address this gap, we examined the effect of a single dose of IV ketamine on cognition… Continue reading Acute cognitive effects of single-dose intravenous #ketamine in major #depressive and posttraumatic stress disorder
Jumping to conclusions and #suicidal behavior in #depression and #psychosis
Highlights • Presence of JTC is higher in depressive and psychotic patients with history of SB, specially under ambiguous conditions. • Within individuals who exhibited JTC, more had a diagnosis of depression than psychosis, and that is related to older age. • JTC might be considered a transdiagnostic construct present in different psychiatric disorders. Abstract… Continue reading Jumping to conclusions and #suicidal behavior in #depression and #psychosis
Effects of Stressful Events and Perceived #Stress on Cognitive Change Among #Depressed Older Adults
Stress is thought to exacerbate cognitive decline in older adults, especially those with late life depression (LLD); however, the specific aspects of stress that are especially deleterious and the aspects of cognition they affect are not clear. For example, it is not known whether the effects result from the exposure to stressful life events or… Continue reading Effects of Stressful Events and Perceived #Stress on Cognitive Change Among #Depressed Older Adults
A Primary Care Agenda for #Brain Health: A Scientific Statement From the American Heart Association
A healthy brain is critical for living a longer and fuller life. The projected aging of the population, however, raises new challenges in maintaining quality of life. As we age, there is increasing compromise of neuronal activity that affects functions such as cognition, also making the brain vulnerable to disease. Once pathology-induced decline begins, few… Continue reading A Primary Care Agenda for #Brain Health: A Scientific Statement From the American Heart Association
Do #β-Blockers Cause #Depression? Systematic Review and Meta-Analysis of Psychiatric Adverse Events During β-Blocker Therapy
β-Blockers are important drugs in the treatment of cardiovascular diseases. They are suspected of inducing various psychiatric adverse events (PAEs), particularly depression, affecting cardiovascular morbidity and mortality. We performed a systematic search for double-blind, randomized controlled trials investigating β-blockers to analyze the risk of PAEs or withdrawal of therapy due to PAEs. We extracted the… Continue reading Do #β-Blockers Cause #Depression? Systematic Review and Meta-Analysis of Psychiatric Adverse Events During β-Blocker Therapy
Common and specific aspects of #anxiety and #depression and the #metabolic syndrome
The associations of anxiety and depression with metabolic syndrome (MetS) are not consistent across studies. Anxiety and depression are highly correlated and traditional methods don't take the structure of this correlation into account. Our aim is to disentangle the relationship of these emotional conditions with MetS, using bifactor models, modelling both general and specific aspects… Continue reading Common and specific aspects of #anxiety and #depression and the #metabolic syndrome
An integrative study of five biological #clocks in somatic and mental #health
Biological clocks have been developed at different molecular levels and were found to be more advanced in the presence of somatic illness and mental disorders. However, it is unclear whether different biological clocks reflect similar aging processes and determinants. In ~3000 subjects, we examined whether five biological clocks (telomere length, epigenetic, transcriptomic, proteomic, and metabolomic… Continue reading An integrative study of five biological #clocks in somatic and mental #health
Risk of #Cardiovascular Disease Mortality in Relation to #Depression and 14 Common Risk Factors
Depression has been linked to a worse prognosis of Cardiovascular disease (CVD), and these two diseases share a variety of common risk factors such as unhealthy lifestyles and chronic medical conditions. However, the potential role of these common risk factors in modulating the association between depression and CVD mortality and whether the co-occurrence of depression… Continue reading Risk of #Cardiovascular Disease Mortality in Relation to #Depression and 14 Common Risk Factors
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