Summary boxRestrictive non-pharmaceutical interventions against COVID-19 (known as ‘lockdowns’) are associated with health harms However, it is challenging to determine whether lockdowns have caused the harms or whether these harms are a direct consequence of the underlying health disaster of the pandemic Careful analysis of excess mortality suggests that lockdowns are not associated with large… Continue reading Is the cure really worse than the disease? The health impacts of #lockdowns during #COVID-19
Tag: coronavirus
Impaired local intrinsic immunity to SARS-CoV-2 infection in severe #COVID-19
SARS-CoV-2 infection can cause severe respiratory COVID-19. However, many individuals present with isolated upper respiratory symptoms, suggesting potential to constrain viral pathology to the nasopharynx. Which cells SARS-CoV-2 primarily targets and how infection influences the respiratory epithelium remains incompletely understood. We performed scRNA-seq on nasopharyngeal swabs from 58 healthy and COVID-19 participants. During COVID-19, we… Continue reading Impaired local intrinsic immunity to SARS-CoV-2 infection in severe #COVID-19
Patient case strongly suggests link between #COVID-19 vaccine and #Bell’s palsy
The case of a patient who experienced two facial palsies - one after the first and another after the second dose of the Pfizer-BioNTech COVID-19 vaccine - strongly suggests that Bell's palsy (facial nerve palsy of unknown cause) is linked to the Pfizer-BioNTech vaccine, doctors write in the journal BMJ Case Reports. They describe the… Continue reading Patient case strongly suggests link between #COVID-19 vaccine and #Bell’s palsy
#Cardiovascular drugs and #COVID-19 clinical outcomes: A living systematic review and meta-analysis
The aim of this study was to continually evaluate the association between cardiovascular drug exposure and COVID-19 clinical outcomes (susceptibility to infection, disease severity, hospitalization, hospitalization length, and all-cause mortality) in patients at risk of/with confirmed COVID-19. MethodsEligible publications were identified from more than 500 databases on 1 November 2020. One reviewer extracted data with… Continue reading #Cardiovascular drugs and #COVID-19 clinical outcomes: A living systematic review and meta-analysis
#COVID-19 #vaccine efficacy and effectiveness—the elephant (not) in the room
Approximately 96 COVID-19 vaccines are at various stages of clinical development.1 At present, we have the interim results of four studies published in scientific journals (on the Pfizer–BioNTech BNT162b2 mRNA vaccine,2 the Moderna–US National Institutes of Health [NIH] mRNA-1273 vaccine,3 the AstraZeneca–Oxford ChAdOx1 nCov-19 vaccine,4 and the Gamaleya GamCovidVac [Sputnik V] vaccine)5 and three studies… Continue reading #COVID-19 #vaccine efficacy and effectiveness—the elephant (not) in the room
#Baricitinib reduces 30-day mortality in older adults with moderate-to-severe #COVID-19 pneumonia
Older adults are at the highest risk of severe disease and death due to COVID-19. Randomized data have shown that baricitinib improves outcomes in these patients, but focused stratified analyses of geriatric cohorts are lacking. Our objective was to analyze the efficacy of baricitinib in older adults with COVID-19 moderate-to-severe pneumonia. MethodsThis is a propensity… Continue reading #Baricitinib reduces 30-day mortality in older adults with moderate-to-severe #COVID-19 pneumonia
Deaths in Children and #Young People in England following #SARS-CoV-2 infection during the first pandemic year: a national study using linked mandatory child death reporting data
This is a preprint. It has not completed peer review. Background Deaths in children and young people (CYP) following SARS-CoV-2 infection are rare. Quantifying the risk of mortality is challenging because of high relative prevalence of asymptomatic and non-specific disease manifestations. Therefore, it is important to differentiate between CYP who have died of SARS-CoV-2 and… Continue reading Deaths in Children and #Young People in England following #SARS-CoV-2 infection during the first pandemic year: a national study using linked mandatory child death reporting data
Auto-immune #hepatitis following #COVID vaccination
Unprecedented loss of life due to the COVID pandemic has necessitated the development of several vaccines in record time. Most of these vaccines have received approval without being extensively whetted for their adverse effect and efficacy profiles. Most adverse effects have been mild, nonetheless, more serious thromboembolic events have also been reported. Autoimmune hepatitis (AIH)… Continue reading Auto-immune #hepatitis following #COVID vaccination
Tolerability and Immunogenicity After a Late Second #Dose or a Third Dose of ChAdOx1 #nCoV-19 (AZD1222)
..Preprints available here are not Lancet publications or necessarily under review with a Lancet journal. These preprints are early stage research papers that have not been peer-reviewed. The findings should not be used for clinical or public health decision making and should not be presented to a lay audience without highlighting that they are preliminary… Continue reading Tolerability and Immunogenicity After a Late Second #Dose or a Third Dose of ChAdOx1 #nCoV-19 (AZD1222)
2 Medical News 