Background It remains imperative to discover the time course that cardiovascular risk factors influence neurodegeneration in males and females and decipher whether the apolipoprotein (APOE) genotype mediates this relationship. Here we perform a large-scale evaluation of the influence of cardiovascular risk and obesity on brain volume in males and females in different age groups.Methods 34… Continue reading #Cardiovascular risk and #obesity impact loss of grey matter volume earlier in males than females
Tag: Brain
Association of Self-Reported #Sleep Characteristics With Neuroimaging Markers of Brain #Aging Years Later in Middle-Aged Adults
ObjectivesTo determine the association between early midlife sleep and advanced brain aging patterns in late midlife.MethodsUsing the CARDIA study, we analyzed sleep data at baseline and 5 years later, focusing on short sleep duration, bad sleep quality (SQ), difficulty initiating and maintaining sleep (DIS and DMS), early morning awakening (EMA), and daytime sleepiness. These were… Continue reading Association of Self-Reported #Sleep Characteristics With Neuroimaging Markers of Brain #Aging Years Later in Middle-Aged Adults
#Accelerometer-derived ‘weekend warrior’ physical #activity pattern and #brain health
Extensive evidence shows the beneficial effect of adhering to a regular physical activity (PA) pattern on brain health. However, whether the ‘weekend warrior’ pattern, characterized by concentrated moderate-to-vigorous PA (MVPA) over 1–2 days, is associated with brain health is unclear. Here, we perform a prospective cohort study including 75,629 participants from the UK Biobank with validated… Continue reading #Accelerometer-derived ‘weekend warrior’ physical #activity pattern and #brain health
Neuroimaging and Clinical Findings in Healthy Middle-Aged Adults With Mild #Traumatic Brain Injury in the PREVENT #Dementia Study
Importance Traumatic brain injuries (TBI) represent an important, potentially modifiable risk factor for dementia. Despite frequently observed vascular imaging changes in individuals with TBI, the relationships between TBI-associated changes in brain imaging and clinical outcomes have largely been overlooked in community cases of TBI.Objective To assess whether TBI are associated with and interact with midlife changes in… Continue reading Neuroimaging and Clinical Findings in Healthy Middle-Aged Adults With Mild #Traumatic Brain Injury in the PREVENT #Dementia Study
#Sex and mental #health are related to subcortical #brain microstructure
SignificanceWe demonstrate the presence of large sex-related differences in the microstructure of subcortical gray matter using advanced noninvasive diffusion MRI in a large cohort of young adults. These sex differences are found in several key brain structures that are important for mental health and are consistent with experimental studies in animals showing cellular differences in… Continue reading #Sex and mental #health are related to subcortical #brain microstructure
Premenopausal bilateral #oophorectomy and #brain white matter brain integrity in later-life
INTRODUCTIONPremenopausal bilateral oophorectomy (PBO) is associated with later-life cognition, but the underlying brain changes remain unclear. We assessed the impact of PBO and PBO age on white matter integrity.METHODSFemale participants with regional diffusion tensor imaging (DTI) metrics of fractional anisotropy (FA) and mean diffusivity (MD) were included (22 with PBO < 40 years; 43 with PBO 40-45… Continue reading Premenopausal bilateral #oophorectomy and #brain white matter brain integrity in later-life
#Cerebrovascular Effects of #Sildenafil in Small Vessel Disease: The OxHARP Trial
BACKGROUND:Vascular cognitive impairment due to cerebral small vessel disease is associated with cerebral pulsatility, white matter hypoperfusion, and reduced cerebrovascular reactivity (CVR), and is potentially improved by endothelium-targeted drugs such as cilostazol. Whether sildenafil, a phosphodiesterase-5 inhibitor, improves cerebrovascular dysfunction is unknown.METHODS:OxHARP trial (Oxford Haemodynamic Adaptation to Reduce Pulsatility) was a double-blind, randomized, placebo-controlled, 3-way… Continue reading #Cerebrovascular Effects of #Sildenafil in Small Vessel Disease: The OxHARP Trial
Prescribed Drug Use and #Aneurysmal Subarachnoid #Hemorrhage IncidenceA Drug-Wide Association Study
Background and ObjectivesCurrent benefits of invasive intracranial aneurysm treatment to prevent aneurysmal subarachnoid hemorrhage (aSAH) rarely outweigh treatment risks. Most intracranial aneurysms thus remain untreated. Commonly prescribed drugs reducing aSAH incidence may provide leads for drug repurposing. We performed a drug-wide association study (DWAS) to systematically investigate the association between commonly prescribed drugs and aSAH… Continue reading Prescribed Drug Use and #Aneurysmal Subarachnoid #Hemorrhage IncidenceA Drug-Wide Association Study
Neuronal activity in the anterior paraventricular nucleus of thalamus positively correlated with #sweetener consumption in mice
Although the brain can discriminate between various sweet substances, the underlying neural mechanisms of this complex behavior remain elusive. This study examines the role of the anterior paraventricular nucleus of the thalamus (aPVT) in governing sweet preference in mice. We fed the mice six different diets with equal sweetness for six weeks: control diet (CD),… Continue reading Neuronal activity in the anterior paraventricular nucleus of thalamus positively correlated with #sweetener consumption in mice
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