Objective Low physical activity (PA) levels are associated with increased mortality. Improved measurement has resulted in stronger proven associations between PA and mortality, but this has not yet translated to improved estimates of the disease burden attributable to low PA. This study estimated how much low PA reduces life expectancy, and how much life expectancy… Continue reading #Physical activity and life #expectancy: a life-table analysis
Tag: Ageing
Ultra-processed #food consumption is associated with the acceleration of biological #aging in the Moli-sani Study
BackgroundHealthy diets have been inversely associated with biological aging. However, the nutritional content is only one aspect of the overall food health potential, and more recently, increasing attention has been paid to nonnutrient food characteristics, such as food processing.ObjectivesTo examine the association of ultra-processed food (UPF) consumption with biological aging measured by circulating blood biomarkers.MethodsCross-sectional… Continue reading Ultra-processed #food consumption is associated with the acceleration of biological #aging in the Moli-sani Study
Association of Self-Reported #Sleep Characteristics With Neuroimaging Markers of Brain #Aging Years Later in Middle-Aged Adults
ObjectivesTo determine the association between early midlife sleep and advanced brain aging patterns in late midlife.MethodsUsing the CARDIA study, we analyzed sleep data at baseline and 5 years later, focusing on short sleep duration, bad sleep quality (SQ), difficulty initiating and maintaining sleep (DIS and DMS), early morning awakening (EMA), and daytime sleepiness. These were… Continue reading Association of Self-Reported #Sleep Characteristics With Neuroimaging Markers of Brain #Aging Years Later in Middle-Aged Adults
#CheekAge, a next-generation epigenetic buccal clock, is predictive of mortality in human blood
While earlier first-generation epigenetic aging clocks were trained to estimate chronological age as accurately as possible, more recent next-generation clocks incorporate DNA methylation information more pertinent to health, lifestyle, and/or outcomes. Recently, we produced a non-invasive next-generation epigenetic clock trained using Infinium MethylationEPIC data from more than 8,000 diverse adult buccal samples. While this clock… Continue reading #CheekAge, a next-generation epigenetic buccal clock, is predictive of mortality in human blood
#Metformin decelerates #aging clock in male monkeys
Highlights•Metformin prevents brain atrophy, elevating cognitive function in aged male primates.Metformin slows the pace of aging across diverse male primate tissues•Metformin counterparts neuronal aging, delivering geroprotection via Nrf2 in male primatesSummaryIn a rigorous 40-month study, we evaluated the geroprotective effects of metformin on adult male cynomolgus monkeys, addressing a gap in primate aging research. The… Continue reading #Metformin decelerates #aging clock in male monkeys
Effect of matcha green #tea on #cognitive functions and #sleep quality in older adults with cognitive decline: A randomized controlled study over 12 months
Lifestyle habits after middle age significantly impact the maintenance of cognitive function in older adults. Nutritional intake is closely related to lifestyle habits; therefore, nutrition is a pivotal factor in the prevention of dementia in the preclinical stages. Matcha green tea powder (matcha), which contains epigallocatechin gallate, theanine, and caffeine, has beneficial effects on cognitive… Continue reading Effect of matcha green #tea on #cognitive functions and #sleep quality in older adults with cognitive decline: A randomized controlled study over 12 months
#Hormone Therapy and Biological #Aging in Postmenopausal Women
Importance Menopause is associated with biological aging, and hormone therapy (HT) is associated with health outcomes in postmenopausal women.Objective To evaluate the association between HT use and discrepancies between chronological and biological age in postmenopausal women as well as the potential modifying role of socioeconomic status (SES).Design, Setting, and Participants This population-based, retrospective cohort study included postmenopausal women… Continue reading #Hormone Therapy and Biological #Aging in Postmenopausal Women
#Ketogenic diet induces p53-dependent cellular #senescence in multiple organs
A ketogenic diet (KD) is a high-fat, low-carbohydrate diet that leads to the generation of ketones. While KDs improve certain health conditions and are popular for weight loss, detrimental effects have also been reported. Here, we show mice on two different KDs and, at different ages, induce cellular senescence in multiple organs, including the heart… Continue reading #Ketogenic diet induces p53-dependent cellular #senescence in multiple organs
Morphological and genetic decoding shows heterogeneous patterns of brain aging in chronic #musculosckeletal pain
Chronic musculoskeletal pain (CMP), a prevalent and heterogeneous condition characterized by persistent pain in various body parts, is a leading cause of disability worldwide and greatly affects a patient’s brain. Apart from experiencing pain, older adults with CMP also have accelerated cognitive decline and higher dementia risk with limited understanding of biological mechanism underlying the… Continue reading Morphological and genetic decoding shows heterogeneous patterns of brain aging in chronic #musculosckeletal pain
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