Objective To compare all licensed drug interventions as oral monotherapy for the acute treatment of migraine episodes in adults.Design Systematic review and network meta-analysis.Data sources Cochrane Central Register of Controlled Trials, Medline, Embase, ClinicalTrials.gov, EU Clinical Trials Register, WHO International Clinical Trials Registry Platform, as well as websites of regulatory agencies and pharmaceutical companies without language restrictions until… Continue reading Comparative effects of drug interventions for the acute management of #migraine episodes in adults: systematic review and network meta-analysis
Prevalence of Critical Errors and Insufficient Peak Inspiratory Flow in Patients Hospitalized With #COPD in a Department of General Internal Medicine: A Cross-Sectional Study
Chronic obstructive pulmonary disease (COPD) is a major cause of morbidity and the third leading cause of mortality worldwide.1 The pharmaceutical treatment of COPD relies mainly on the administration of medications via inhalation. However, the effectiveness of these treatments is very often hampered by the suboptimal utilization of inhalers, which may arise due to errors in… Continue reading Prevalence of Critical Errors and Insufficient Peak Inspiratory Flow in Patients Hospitalized With #COPD in a Department of General Internal Medicine: A Cross-Sectional Study
#Antibiotics damage the #colonic mucus barrier in a #microbiota-independent manner
Antibiotic use is a risk factor for development of inflammatory bowel diseases (IBDs). IBDs are characterized by a damaged mucus layer, which does not separate the intestinal epithelium from the microbiota. Here, we hypothesized that antibiotics affect the integrity of the mucus barrier, which allows bacterial penetrance and predisposes to intestinal inflammation. We found that… Continue reading #Antibiotics damage the #colonic mucus barrier in a #microbiota-independent manner
Effects of interventions to combat #tobacco addiction: #Cochrane update of 2021 to 2023 reviews
To summarise systematic reviews on tobacco addiction published by the Cochrane Tobacco Addiction Group (CTAG) from 2021 to 2023.MethodsWe identified all new and updated Cochrane Reviews published by CTAG between 2021 and 2023. We present key results from these reviews and discuss promising avenues for future research.ResultsCTAG published five new reviews and one overview of… Continue reading Effects of interventions to combat #tobacco addiction: #Cochrane update of 2021 to 2023 reviews
Upper #Gastrointestinal Mucosal Damage and Subsequent Risk of #Parkinson Disease
Importance The gut-first hypothesis of Parkinson disease (PD) has gained traction, yet potential inciting events triggering Parkinson pathology from gut-related factors remain unclear. While Helicobacter pylori infection is linked to mucosal damage (MD) and PD, it is unknown how upper gastrointestinal MD from any source increases PD risk.Objective To evaluate any association between upper endoscopy findings of MD and… Continue reading Upper #Gastrointestinal Mucosal Damage and Subsequent Risk of #Parkinson Disease
#Vision Impairment and the Population Attributable Fraction of #Dementia in Older Adults
Importance Vision impairment is a potentially modifiable risk factor for dementia. Although few prior studies have estimated the contribution of vision impairments to dementia, none have reported on multiple objectively measured vision impairments (eg, distance and near visual acuity and contrast sensitivity) in a nationally representative sample of older adults.Objective To quantify population attributable fractions of dementia… Continue reading #Vision Impairment and the Population Attributable Fraction of #Dementia in Older Adults
#Inflammation, #Cholesterol, #Lipoprotein(a), and 30-Year #Cardiovascular Outcomes in Women
High-sensitivity C-reactive protein (CRP), low-density lipoprotein (LDL) cholesterol, and lipoprotein(a) levels contribute to 5-year and 10-year predictions of cardiovascular risk and represent distinct pathways for pharmacologic intervention. More information about the usefulness of these biomarkers for predicting cardiovascular risk over longer periods of time in women is needed because early-life intervention represents an important risk-reduction… Continue reading #Inflammation, #Cholesterol, #Lipoprotein(a), and 30-Year #Cardiovascular Outcomes in Women
#Spike Protein Impairs #Mitochondrial Function in Human Cardiomyocytes: Mechanisms Underlying #Cardiac Injury in COVID-19
Background: COVID-19 has a major impact on cardiovascular diseases and may lead to myocarditis or cardiac failure. The clove-like spike (S) protein of SARS-CoV-2 facilitates its transmission and pathogenesis. Cardiac mitochondria produce energy for key heart functions. We hypothesized that S1 would directly impair the functions of cardiomyocyte mitochondria, thus causing cardiac dysfunction.Methods: Through the Seahorse Mito… Continue reading #Spike Protein Impairs #Mitochondrial Function in Human Cardiomyocytes: Mechanisms Underlying #Cardiac Injury in COVID-19
#Vision Impairment and the Population Attributable Fraction of #Dementia in Older #Adults
Importance Vision impairment is a potentially modifiable risk factor for dementia. Although few prior studies have estimated the contribution of vision impairments to dementia, none have reported on multiple objectively measured vision impairments (eg, distance and near visual acuity and contrast sensitivity) in a nationally representative sample of older adults.Objective To quantify population attributable fractions of dementia… Continue reading #Vision Impairment and the Population Attributable Fraction of #Dementia in Older #Adults
