The rising prevalence of prediabetes has increased the risk of diabetes, particularly among younger populations, if timely interventions are not implemented. In India, the limited availability of cohort-based incidence studies underscores the need for retrospective analyses using hospital-based electronic medical information systems (EMIS). This study estimates the transition probabilities and duration of stay in the… Continue reading Transition between #prediabetic and #diabetic stages in an urban community in india: a decade-long retrospective cohort study
#Ultra-processed foods and human health: the main thesis and the evidence
This first paper in a three-part Lancet Series combines narrative and systematic reviews with original analyses and meta-analyses to assess three hypotheses concerning a dietary pattern based on ultra-processed foods. The first hypothesis—that this pattern is globally displacing long-established diets centred on whole foods and their culinary preparation as dishes and meals—is supported by decades… Continue reading #Ultra-processed foods and human health: the main thesis and the evidence
A six-year longitudinal study identifies a #statin -independent association between low LDL- #cholesterol and risk of type 2 #diabetes
Statin therapy has been associated with increased risk of type 2 diabetes (T2D). We investigated the relationship between Low-Density Lipoprotein Cholesterol (LDL-C) plasma concentrations and incident T2D and evaluated the modifying effect of statin therapy in a large population-based cohort.MethodsIndividuals free of T2D and cardiovascular disease at baseline were followed longitudinally for the development of… Continue reading A six-year longitudinal study identifies a #statin -independent association between low LDL- #cholesterol and risk of type 2 #diabetes
#Electroacupuncture modulates myocardial insulin signaling and inflammatory markers in a rat model of type 2 #diabetes
Objective: To evaluate the effects of electroacupuncture (EA) on myocardial insulin resistance (IR) in Zucker diabetic fatty (ZDF) rats, an established model for type 2 diabetes mellitus (T2DM).Methods: Twenty-four ZDF-Leprfa/fa rats were randomized to: (1) ZDF group (n = 8); (2) ZDF + PIO (pioglitazone) group (n = 8); and (3) ZDF + EA group… Continue reading #Electroacupuncture modulates myocardial insulin signaling and inflammatory markers in a rat model of type 2 #diabetes
Alcohol’s Effects on the Lung and Lung Disease
Purpose: Alcohol misuse is widely accepted as an independent risk factor for a wide variety of lung diseases, such as pneumonia and acute respiratory distress syndrome. Alcohol induces changes in the regulatory mechanisms of the lung, both at a mechanical and immunological level. Understanding these changes might help discover new targets for drugs and therapeutic… Continue reading Alcohol’s Effects on the Lung and Lung Disease
Saline and #N-acetylcysteine based strategies and other approaches to prevent the risk of CA- #AKI: a meta-analysis
AbstractBackground: While hydration is currently the most evidence-supported strategy for preventing contrast-associated acute kidney injury (CA-AKI) in patients undergoing cardiovascular angiography, the potential benefits of combining a saline and N-acetylcysteine (NAC) based strategy with additional pharmacologic interventions remain uncertain.Methods: We conducted a search for randomized controlled trials (RCTs) in PubMed, Embase, and the Cochrane library… Continue reading Saline and #N-acetylcysteine based strategies and other approaches to prevent the risk of CA- #AKI: a meta-analysis
Is there any role for #HBV pgRNA in #fibrosis and #HCC predisposition?
Aim: In this cohort, we aimed to study the evolution of pregenomic RNA (pgRNA) during treatment and compare it with other disease scores such as FIB-4 and PAGE-B.Methods: Eighty-eight HBeAg negative CHB who received long-term treatment with NAs were included. A quantitative HBV S antigen (HBsAg) assay was performed, and viral HBV DNA was quantified… Continue reading Is there any role for #HBV pgRNA in #fibrosis and #HCC predisposition?
#Statins and clinical outcomes in patients with advanced #hepatocellular carcinoma treated with #Atezolizumab plus #Bevacizumab
The impact of statins on patients receiving immune checkpoint inhibitors for advanced hepatocellular carcinoma (aHCC) remains unclear. This study aimed to evaluate whether statins influence overall survival (OS) and progression-free survival (PFS) in aHCC patients receiving Atezolizumab + Bevacizumab (A + B). ARTE is a prospectively maintained dataset of 305 aHCC patients treated with A… Continue reading #Statins and clinical outcomes in patients with advanced #hepatocellular carcinoma treated with #Atezolizumab plus #Bevacizumab
Multicentre, double-blind, randomized placebo-controlled trial to evaluate the therapeutic efficacy of #nutraceutical combination in the treatment of #allergic #rhinitis
BackgroundAllergic rhinitis (AR) is a widely diffused atopic disease that is hardly managed by conventional therapy, especially in the long-term. Fatty acids (FAs), which possess both anti-inflammatory and immunomodulatory properties, could be used to control AR symptoms.ObjectiveWe aimed at evaluating the benefits (efficacy in reducing symptoms and safety) of using an oral supplement containing FAs… Continue reading Multicentre, double-blind, randomized placebo-controlled trial to evaluate the therapeutic efficacy of #nutraceutical combination in the treatment of #allergic #rhinitis
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