Neuropathic pain affects millions of people worldwide, yet the molecular mechanisms of how it develops and persists are poorly understood. Given that males have historically been utilized as the primary sex in preclinical studies, less is known about the female neuroinflammatory response to injury, formation of pain, or response to pain-relieving therapies. Macrophages contribute to… Continue reading Behavioral and inflammatory sex differences revealed by celecoxib nanotherapeutic treatment of peripheral neuroinflammation
Long COVID after breakthrough SARS-CoV-2 infection
The post-acute sequelae of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection—also referred to as Long COVID—have been described, but whether breakthrough SARS-CoV-2 infection (BTI) in vaccinated people results in post-acute sequelae is not clear. In this study, we used the US Department of Veterans Affairs national healthcare databases to build a cohort of 33,940… Continue reading Long COVID after breakthrough SARS-CoV-2 infection
Association of Bariatric Surgery With Cancer Risk and Mortality in Adults With Obesity
Importance Obesity increases the incidence and mortality from some types of cancer, but it remains uncertain whether intentional weight loss can decrease this risk. Objective To investigate whether bariatric surgery is associated with lower cancer risk and mortality in patients with obesity. Design, Setting, and Participants In the SPLENDID (Surgical Procedures and Long-term Effectiveness in… Continue reading Association of Bariatric Surgery With Cancer Risk and Mortality in Adults With Obesity
Increases in COVID-19 are unrelated to levels of vaccination across 68 countries and 2947 counties in the United States
Vaccines currently are the primary mitigation strategy to combat COVID-19 around the world. For instance, the narrative related to the ongoing surge of new cases in the United States (US) is argued to be driven by areas with low vaccination rates [1]. A similar narrative also has been observed in countries, such as Germany and… Continue reading Increases in COVID-19 are unrelated to levels of vaccination across 68 countries and 2947 counties in the United States
Loss of functional heterogeneity along the CA3 transverse axis in aging
Age-related deficits in pattern separation have been postulated to bias the output of hippocampal memory processing toward pattern completion, which can cause deficits in accurate memory retrieval. Although the CA3 region of the hippocampus is often conceptualized as a homogeneous network involved in pattern completion, growing evidence demonstrates a functional gradient in CA3 along the… Continue reading Loss of functional heterogeneity along the CA3 transverse axis in aging
Foreign Materials in Blood Samples of Recipients of COVID-19 Vaccines
The Korea Veritas Doctors (KoVeDocs) for COVID-19 previously found certain foreign materials and moving parasite-like entities in the Pfizer and Moderna mRNA COVID-19 vaccines as those vaccines were warmed to near room temperature (Jeon, 2022). Here we report on similar foreign materials found in samples of centrifuged blood from 8 COVID-19 vaccine recipients as contrasted… Continue reading Foreign Materials in Blood Samples of Recipients of COVID-19 Vaccines
All Cause Mortality and COVID-19 Injections: Evidence from 28 Weeks of Public Health England “COVID-19 Vaccine Surveillance Reports”
According to data collected in the UK for weeks 34-52 in 2021 (excluding week 51 which was not covered) and in weeks 1-12 of 2022 — a period of 28 weeks during which the genetic “vaccines” from Pfizer, Moderna, and AstraZeneca were being pressed upon the public — deaths reported to Public Health England (PHE)… Continue reading All Cause Mortality and COVID-19 Injections: Evidence from 28 Weeks of Public Health England “COVID-19 Vaccine Surveillance Reports”
Anti-HBc levels are associated with liver inflammation and response to peginterferon in chronic hepatitis B patients
BackgroundEmerging evidence suggests a pivotal role for B-cell responses in the natural history of chronic hepatitis B (CHB). Serum levels of antibodies to HBcAg (anti-HBc) vary across infection stages, but their role in predicting response to antiviral therapy is uncertain. MethodsAnti-HBc levels were assessed before peginterferon (PEG-IFN) therapy in CHB patients who either initiated de… Continue reading Anti-HBc levels are associated with liver inflammation and response to peginterferon in chronic hepatitis B patients
Revisiting Pediatric COVID-19 Cases in Counties With and Without School Mask Requirements—United States, July 1—October 20 2021
Background: There has been considerable debate around mask requirements in schools in the United States and other countries during the Covid-19 pandemic. To date, there have been no randomized controlled trials of mask requirements in children. All analyses of the effectiveness of school mask mandates have relied on observational studies. The Centers for Disease Control… Continue reading Revisiting Pediatric COVID-19 Cases in Counties With and Without School Mask Requirements—United States, July 1—October 20 2021
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