African American (AA) prostate cancer associates with vitamin D3 deficiency, but vitamin D receptor (VDR) genomic actions have not been investigated in this context. We undertook VDR proteogenomic analyses in European American (EA) and AA prostate cell lines and four clinical cohorts. Rapid immunoprecipitation mass spectrometry of endogenous protein (RIME) analyses revealed that nonmalignant AA… Continue reading African American Prostate Cancer Displays Quantitatively Distinct Vitamin D Receptor Cistrome-transcriptome Relationships Regulated by BAZ1A
Category: Urology
Cranberries for preventing urinary tract infections
Cranberries contain proanthocyanidins (PACs), which inhibit the adherence of p‐fimbriated Escherichia coli to the urothelial cells lining the bladder. Cranberry products have been used widely for several decades to prevent urinary tract infections (UTIs). This is the fifth update of a review first published in 1998 and updated in 2003, 2004, 2008, and 2012.ObjectivesTo assess… Continue reading Cranberries for preventing urinary tract infections
Using source-associated mobile genetic elements to identify zoonotic extraintestinal E. coli infections
Highlights•Meat may be an important vehicle for human exposure to extraintestinal pathogenic E. coli strains from food animals.•We present a novel approach for predicting the origins of clinical E. coli isolates.•Approximately 8% of the clinical E. coli isolates in our population appeared to be foodborne zoonotic strains.•Foodborne zoonotic E. coli strains were associated with asymptomatic… Continue reading Using source-associated mobile genetic elements to identify zoonotic extraintestinal E. coli infections
Fifteen-Year Outcomes after Monitoring, Surgery, or Radiotherapy for Prostate Cancer
BACKGROUNDBetween 1999 and 2009 in the United Kingdom, 82,429 men between 50 and 69 years of age received a prostate-specific antigen (PSA) test. Localized prostate cancer was diagnosed in 2664 men. Of these men, 1643 were enrolled in a trial to evaluate the effectiveness of treatments, with 545 randomly assigned to receive active monitoring, 553… Continue reading Fifteen-Year Outcomes after Monitoring, Surgery, or Radiotherapy for Prostate Cancer
Covid-19 vaccination BNT162b2 temporarily impairs semen concentration and total motile count among semen donors
AbstractBackgroundThe development of covid-19 vaccinations represents a notable scientific achievement. Nevertheless, concerns have been raised regarding their possible detrimental impact on male fertility ObjectiveTo investigate the effect of covid-19 BNT162b2 (Pfizer) vaccine on semen parameters among semen donors (SD). Methods37 SD from three sperm banks that provided 220 samples, were included in that retrospective longitudinal… Continue reading Covid-19 vaccination BNT162b2 temporarily impairs semen concentration and total motile count among semen donors
MP38-16 IS IT TIME FOR FPMRS TO PRESCRIBE VIBRATORS?
Only recently, the stigma of women using vibrators for sexual pleasure has started to fade; however, it still remains a societal taboo and is surrounded with anxiety despite a variety of potential health benefits from its use. Due to the sensitive nature of the conditions Female Pelvic Medicine and Reconstructive Surgery (FPMRS) specialists treat, they… Continue reading MP38-16 IS IT TIME FOR FPMRS TO PRESCRIBE VIBRATORS?
Longitudinal multi-omics analyses link gut microbiome dysbiosis with recurrent urinary tract infections in women
Recurrent urinary tract infections (rUTIs) are a major health burden worldwide, with history of infection being a significant risk factor. While the gut is a known reservoir for uropathogenic bacteria, the role of the microbiota in rUTI remains unclear. We conducted a year-long study of women with (n = 15) and without (n = 16) history of rUTI, from… Continue reading Longitudinal multi-omics analyses link gut microbiome dysbiosis with recurrent urinary tract infections in women
Microbiomes of Urine and the Prostate Are Linked to Human Prostate Cancer Risk Groups
Bacteria play a suspected role in the development of several cancer types, and associations between the presence of particular bacteria and prostate cancer have been reported. ObjectiveTo provide improved characterisation of the prostate and urine microbiome and to investigate the prognostic potential of the bacteria present. Design, setting, and participantsMicrobiome profiles were interrogated in sample… Continue reading Microbiomes of Urine and the Prostate Are Linked to Human Prostate Cancer Risk Groups
Alternative to prophylactic antibiotics for the treatment of recurrent urinary tract infections in women: multicentre, open label, randomised, non-inferiority trial
To test and compare the efficacy of methenamine hippurate for prevention of recurrent urinary tract infections with the current standard prophylaxis of daily low dose antibiotics. Design Multicentre, open label, randomised, non-inferiority trial. Setting Eight centres in the UK, recruiting from June 2016 to June 2018. Participants Women aged ≥18 years with recurrent urinary tract… Continue reading Alternative to prophylactic antibiotics for the treatment of recurrent urinary tract infections in women: multicentre, open label, randomised, non-inferiority trial
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