As physicians continually explore avenues for promoting overall health, recent research has shed light on a potential ally in the fight against cataracts – Vitamin C. This essential nutrient, long celebrated for its immune-boosting properties, is now gaining recognition for its potential role in reducing the risk of cataract development. In this blog post, I… Continue reading Enhancing Vision: Exploring the Link Between Vitamin #C and Reduced #Cataract Risks – A Physician’s Perspective
Category: supplements
Vitamin #B12 is a limiting factor for induced cellular plasticity and #tissue repair
Transient reprogramming by the expression of OCT4, SOX2, KLF4 and MYC (OSKM) is a therapeutic strategy for tissue regeneration and rejuvenation, but little is known about its metabolic requirements. Here we show that OSKM reprogramming in mice causes a global depletion of vitamin B12 and molecular hallmarks of methionine starvation. Supplementation with vitamin B12 increases the efficiency… Continue reading Vitamin #B12 is a limiting factor for induced cellular plasticity and #tissue repair
#Nicotinamide enhances natural #killer cell function and yields remissions in patients with non-Hodgkin #lymphoma
Administration of haploidentical donor natural killer (NK) cells, rituximab, and IL-2 to patients with non-Hodgkin lymphoma (NHL) has been shown to be safe, but the objective response rate was low, suggesting that further strategies to improve NK cell engraftment and function are needed. Here, Cichocki and colleagues showed that supplementation with nicotinamide during ex vivo… Continue reading #Nicotinamide enhances natural #killer cell function and yields remissions in patients with non-Hodgkin #lymphoma
Effect of Vitamin #D Supplements on Relapse or Death in a p53-Immunoreactive Subgroup With #Digestive Tract Cancer
Recent meta-analyses of randomized clinical trials found that daily vitamin D3 supplementation had beneficial effects on cancer mortality, although the results are still controversial.Objective To examine whether vitamin D supplementation reduces the risk of relapse or death in a supgroup of patients with digestive tract cancer who were p53 immunoreactive.Design, Setting, and Participants This was a post… Continue reading Effect of Vitamin #D Supplements on Relapse or Death in a p53-Immunoreactive Subgroup With #Digestive Tract Cancer
Human #cells experience a #Zn2+ pulse in early G1
Highlights•Human cells experience a transient zinc pulse in early G1•The magnitude of the pulse tracks with the amount of zinc in the cytosol and media•Knockdown of MTF-1 decreases metallothionein and increases the zinc pulse•Cells pause proliferation until labile cellular zinc is in the optimum range SummaryZinc is an essential micronutrient required for all domains of… Continue reading Human #cells experience a #Zn2+ pulse in early G1
Vitamin D status & associations with inflammation in older adults
Research studies have observed associations of vitamin D with inflammation but data in representative older adult studies is lacking. We aimed to investigate the association of C-reactive protein (CRP) with vitamin D status in a representative sample of the older Irish population. The concentrations of 25-hydroxyvitamin D (25(OH)D) and CRP was measured in 5,381 community… Continue reading Vitamin D status & associations with inflammation in older adults
Vitamin D supplementation and major cardiovascular events: D-Health randomised controlled trial
To investigate whether supplementing older adults with monthly doses of vitamin D alters the incidence of major cardiovascular events Design Randomised, double blind, placebo controlled trial of monthly vitamin D (the D-Health Trial). Computer generated permuted block randomisation was used to allocate treatments.Setting Australia from 2014 to 2020.Participants 21 315 participants aged 60-84 years at enrolment. Exclusion criteria were… Continue reading Vitamin D supplementation and major cardiovascular events: D-Health randomised controlled trial
Efficacy of vitamin D3 supplementation on cancer mortality: Systematic review and individual patient data meta-analysis of randomised controlled trials
AbstractTo evaluate the effect of vitamin D3 supplementation on cancer mortality in the general population and on prognosis in cancer patients, a systematic review and meta-analysis of randomised, placebo-controlled trials (RCTs) and individual patient data (IPD) was conducted. Overall, 14 RCTs with a total of 104,727 participants (2015 cancer deaths) were identified and 7 RCTs, including… Continue reading Efficacy of vitamin D3 supplementation on cancer mortality: Systematic review and individual patient data meta-analysis of randomised controlled trials
African American Prostate Cancer Displays Quantitatively Distinct Vitamin D Receptor Cistrome-transcriptome Relationships Regulated by BAZ1A
African American (AA) prostate cancer associates with vitamin D3 deficiency, but vitamin D receptor (VDR) genomic actions have not been investigated in this context. We undertook VDR proteogenomic analyses in European American (EA) and AA prostate cell lines and four clinical cohorts. Rapid immunoprecipitation mass spectrometry of endogenous protein (RIME) analyses revealed that nonmalignant AA… Continue reading African American Prostate Cancer Displays Quantitatively Distinct Vitamin D Receptor Cistrome-transcriptome Relationships Regulated by BAZ1A
