Apathy adversely affects prognosis and survival of patients with frontotemporal dementia (FTD). We test whether apathy develops in presymptomatic genetic FTD, and is associated with cognitive decline and brain atrophy.. ..Results Apathy severity increased over time in presymptomatic carriers, but not in non‐carriers. In presymptomatic carriers, baseline apathy predicted cognitive decline over two years, but… Continue reading #Apathy in presymptomatic genetic frontotemporal #dementia predicts cognitive decline and is driven by structural brain changes
Category: Psychiatry
#Lipoprotein (a) and the risk of elevated #depressive symptoms: The Multi-Ethnic Study of Atherosclerosis
Previous studies suggested a potential relationship between plasma lipoprotein (a) [Lp(a)] and elevated depressive symptoms. We aimed to investigate any such relationship in the Multi-Ethnic Study of Atherosclerosis participants who were free of cardiovascular events. Analysis included 4938 participants without elevated depressive symptoms and with Lp(a) levels measured at baseline. Participants were examined at four… Continue reading #Lipoprotein (a) and the risk of elevated #depressive symptoms: The Multi-Ethnic Study of Atherosclerosis
Assessment of Physician #Sleep and Wellness, #Burnout, and Clinically Significant Medical Errors
Sleep-related impairment in physicians is an occupational hazard associated with long and sometimes unpredictable work hours and may contribute to burnout and self-reported clinically significant medical error.. ..Of all physicians invited to participate in the survey, 7700 of 19 384 attending physicians (40%) and 3695 of 7257 house staff physicians (51%) completed sleep-related impairment items, including… Continue reading Assessment of Physician #Sleep and Wellness, #Burnout, and Clinically Significant Medical Errors
Older Adults and the Mental Health Effects of #COVID-19
As the coronavirus disease 2019 (COVID-19) began to spread in the US in early 2020, older adults experienced disproportionately greater adverse effects from the pandemic including more severe complications, higher mortality, concerns about disruptions to their daily routines and access to care, difficulty in adapting to technologies like telemedicine, and concerns that isolation would exacerbate… Continue reading Older Adults and the Mental Health Effects of #COVID-19
#Loneliness, Mental Health, and Substance Use among US Young Adults during #COVID-19
As COVID-19 converges with loneliness and addiction epidemics in the US, both public health and mental health experts forecast dramatic increases in substance use and mental health conditions. This cross-sectional study evaluated relationships of loneliness with depression, anxiety, alcohol use, and drug use during COVID-19, and assessed perceived increases in these symptoms in young adults.… Continue reading #Loneliness, Mental Health, and Substance Use among US Young Adults during #COVID-19
Acute social #isolation evokes midbrain craving responses similar to #hunger
When people are forced to be isolated from each other, do they crave social interactions? To address this question, we used functional magnetic resonance imaging to measure neural responses evoked by food and social cues after participants (n = 40) experienced 10 h of mandated fasting or total social isolation. After isolation, people felt lonely and craved social… Continue reading Acute social #isolation evokes midbrain craving responses similar to #hunger
Cynical #hostility relates to a lack of habituation of the #cardiovascular response to repeated acute stress
Hostility is associated with increased risk for cardiovascular disease. Heightened cardiovascular reactivity to psychological stress has been proposed as a potential mechanism. Recent work has emphasized a need to measure cardiovascular reactivity across multiple stress exposures to assess potential habituation over time. The aims of the current study were (a) to examine the relationship between… Continue reading Cynical #hostility relates to a lack of habituation of the #cardiovascular response to repeated acute stress
#Mediterranean diet, #stress resilience, and aging in nonhuman primates
Persistent psychological stress increases the risk of many chronic diseases of aging. Little progress has been made to effectively reduce stress responses or mitigate stress effects suggesting a need for better understanding of factors that influence stress responses. Limited evidence suggests that diet may be a factor in modifying the effects of stress. However, long-term… Continue reading #Mediterranean diet, #stress resilience, and aging in nonhuman primates
Individual and combined associations between cardiorespiratory #fitness and grip strength with common #mental disorders: a prospective cohort study in the UK Biobank
Depression and anxiety are common mental disorders that increase physical health risks and are leading causes of global disability. Several forms of physical fitness could be modifiable risk factors for common mental disorders in the population. We examined associations between individual and combined markers of cardiorespiratory fitness and grip strength with the incidence of common… Continue reading Individual and combined associations between cardiorespiratory #fitness and grip strength with common #mental disorders: a prospective cohort study in the UK Biobank
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