Background E-cigarette use is now prevalent among adolescents and young adults, raising concerns over potential adverse long-term health effects. Although it is hypothesised that e-cigarettes promote inflammation, studies have yielded conflicting evidence. Our previous work showed that JUUL, a popular e-cigarette brand, elicited minimal lung inflammation but induced significant molecular changes in adult C57BL/6 mice.Methods… Continue reading Sex-specific alterations in pulmonary metabolic, xenobiotic and lipid signalling pathways after #e-cigarette aerosol exposure during adolescence in mice
Category: Pneumology
Prevalence of Critical Errors and Insufficient Peak Inspiratory Flow in Patients Hospitalized With #COPD in a Department of General Internal Medicine: A Cross-Sectional Study
Chronic obstructive pulmonary disease (COPD) is a major cause of morbidity and the third leading cause of mortality worldwide.1 The pharmaceutical treatment of COPD relies mainly on the administration of medications via inhalation. However, the effectiveness of these treatments is very often hampered by the suboptimal utilization of inhalers, which may arise due to errors in… Continue reading Prevalence of Critical Errors and Insufficient Peak Inspiratory Flow in Patients Hospitalized With #COPD in a Department of General Internal Medicine: A Cross-Sectional Study
#Antibiotic-driven #dysbiosis in early life disrupts indole-3-propionic acid production and exacerbates #allergic airway inflammation in adulthood
•Early-life antibiotics increase the risk of allergy in adulthood•Antibiotics cause short-term disruption of the microbiome and systemic metabolome•Dysfunctional mitochondria in the airway epithelium lead to exaggerated inflammation•Indole-3-propionic acid counters the detrimental effects of early-life antibioticsSummaryAntibiotic use in early life disrupts microbial colonization and increases the risk of developing allergies and asthma. We report that mice… Continue reading #Antibiotic-driven #dysbiosis in early life disrupts indole-3-propionic acid production and exacerbates #allergic airway inflammation in adulthood
#Smartphone application versus written material for #smoking reduction and cessation in individuals undergoing low-dose computed tomography (LDCT) screening for lung cancer: a phase II open-label randomised controlled trial
BackgroundCounseling, nicotine replacement, and other cessation medications have been proven effective in smoking cessation. The wide-scale adoption of smartphones and other mobile devices has opened new possibilities for scalable and personalized smoking cessation approaches. The study investigated whether a smartphone application would be more effective than written material for smoking cessation and reduction in smoking… Continue reading #Smartphone application versus written material for #smoking reduction and cessation in individuals undergoing low-dose computed tomography (LDCT) screening for lung cancer: a phase II open-label randomised controlled trial
Adherence to the #low-fat diet pattern reduces the risk of #lung cancer in American adults aged 55 years and above: a prospective cohort study
ObjectivesThere is little evidence on the association between low-fat dietary patterns and lung cancer risk among middle-aged and older adults. To fill this gap, we comprehensively investigated the association of adherence to a low-fat diet (LFD) and intake of different fat components including saturated, monounsaturated, and polyunsaturated fatty acids with incidence of lung cancer and… Continue reading Adherence to the #low-fat diet pattern reduces the risk of #lung cancer in American adults aged 55 years and above: a prospective cohort study
Older adults at greater risk for #Alzheimer’s disease show stronger associations between sleep #apnea severity in #REM sleep and verbal memory
Obstructive sleep apnea (OSA) increases risk for cognitive decline and Alzheimer’s disease (AD). While the underlying mechanisms remain unclear, hypoxemia during OSA has been implicated in cognitive impairment. OSA during rapid eye movement (REM) sleep is usually more severe than in non-rapid eye movement (NREM) sleep, but the relative effect of oxyhemoglobin desaturation during REM… Continue reading Older adults at greater risk for #Alzheimer’s disease show stronger associations between sleep #apnea severity in #REM sleep and verbal memory
#Antibiotics Not Associated with Shorter Duration or Reduced Severity of Acute Lower #Respiratory Tract Infection
BackgroundAntibiotic use remains common for the treatment of lower respiratory tract infections. The objective of this study was to evaluate the impact of antibiotic use on the duration and severity of acute lower respiratory tract infection (LRTI).ParticipantsAdult patients presenting to US primary or urgent care sites with a chief complaint of cough and symptoms consistent… Continue reading #Antibiotics Not Associated with Shorter Duration or Reduced Severity of Acute Lower #Respiratory Tract Infection
Sleep #Apnea and Incident #Stroke in a National Cohort of Black and White Adults
Background and ObjectivesRacial/ethnic differences have been documented in the relationship between obstructive sleep apnea (OSA) and stroke incidence, yet racial differences in OSA symptoms or treatment and their relationship with stroke incidence are underexplored and may contribute to stroke disparities. We comprehensively examined OSA symptoms and their relationships to stroke incidence by race/ethnicity.MethodsData were collected… Continue reading Sleep #Apnea and Incident #Stroke in a National Cohort of Black and White Adults
Deciphering #Tachypnea: A Physician’s Perspective on Pathophysiology and Implications
Tachypnea, a rapid and shallow breathing pattern, is a clinical sign that beckons the attention of physicians, serving as a vital indicator of an underlying physiological disturbance. As physicians, our keen understanding of the pathophysiology behind tachypnea is pivotal in unraveling its implications and guiding us toward the appropriate diagnostic and therapeutic interventions. Join me… Continue reading Deciphering #Tachypnea: A Physician’s Perspective on Pathophysiology and Implications
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