Antimicrobial resistance (AMR) poses a global threat to public health. While antibiotic overuse is a primary driver, emerging evidence suggests that non-antibiotic medications (NAMs) may also contribute. This concern is particularly relevant in residential aged care facilities (RACFs), where both NAMs and antibiotics are frequently used. We investigated whether nine commonly used NAMs in RACFs,… Continue reading The effect of commonly used non- #antibiotic medications on #antimicrobial resistance development in #Escherichia coli
Category: Pain
Risk of #dementia following #gabapentin prescription in chronic low back #pain patients
Introduction Gabapentin is widely used to treat chronic pain, but its association with cognitive decline and dementia remains unclear. This study examined whether gabapentin prescription is associated with dementia in adults with chronic low back pain.Methods We conducted a retrospective cohort study using the TriNetX national database of de-identified patient records from 2004 to 2024.… Continue reading Risk of #dementia following #gabapentin prescription in chronic low back #pain patients
“Being away from everything”: Exploring the importance of access to #nature for individuals living with chronic low #back #pain
Highlights• Accessing nature spaces is important in the self-management of chronic low back pain.• Accessibility is undermined by disability, environmental obstacles or hazards, or proximity.• This represents an unmet clinical need which could be explored through virtual reality therapy. AbstractChronic low back pain is a persistent and debilitating condition, and therapeutic outcomes in the long… Continue reading “Being away from everything”: Exploring the importance of access to #nature for individuals living with chronic low #back #pain
Common interventional procedures for chronic non-cancer #spine #pain: a systematic review and network meta-analysis of randomised trials
Objective To address the comparative effectiveness of common interventional procedures for chronic non-cancer (axial or radicular) spine pain.Design Systematic review and network meta-analysis (NMA) of randomised controlled trials (RCTs).Data sources Medline, Embase, CINAHL, CENTRAL, and Web of Science from inception to 24 January 2023.Study selection RCTs that enrolled patients with chronic non-cancer spine pain, randomised… Continue reading Common interventional procedures for chronic non-cancer #spine #pain: a systematic review and network meta-analysis of randomised trials
The endocannabinoid N-arachidonoyl dopamine is critical for #hyperalgesia induced by chronic #sleep disruption
Chronic pain is highly prevalent and is linked to a broad range of comorbidities, including sleep disorders. Epidemiological and clinical evidence suggests that chronic sleep disruption (CSD) leads to heightened pain sensitivity, referred to as CSD-induced hyperalgesia. However, the underlying mechanisms are unclear. The thalamic reticular nucleus (TRN) has unique integrative functions in sensory processing,… Continue reading The endocannabinoid N-arachidonoyl dopamine is critical for #hyperalgesia induced by chronic #sleep disruption
Opioid analgesia for acute low back pain and neck pain (the OPAL trial): a randomised placebo-controlled trial
Opioid analgesics are commonly used for acute low back pain and neck pain, but supporting efficacy data are scarce. We aimed to investigate the efficacy and safety of a judicious short course of an opioid analgesic for acute low back pain and neck pain.MethodsOPAL was a triple-blinded, placebo-controlled randomised trial that recruited adults (aged ≥18… Continue reading Opioid analgesia for acute low back pain and neck pain (the OPAL trial): a randomised placebo-controlled trial
Effect of statin therapy on muscle symptoms: an individual participant data meta-analysis of large-scale, randomised, double-blind trials
BackgroundStatin therapy is effective for the prevention of atherosclerotic cardiovascular disease and is widely prescribed, but there are persisting concerns that statin therapy might frequently cause muscle pain or weakness. We aimed to address these through an individual participant data meta-analysis of all recorded adverse muscle events in large, long-term, randomised, double-blind trials of statin… Continue reading Effect of statin therapy on muscle symptoms: an individual participant data meta-analysis of large-scale, randomised, double-blind trials
Neural Signatures of Pain Modulation in Short-Term and Long-Term Mindfulness Training: A Randomized Active-Control Trial
Mindfulness-based interventions are widely used to target pain, yet their neural mechanisms of action are insufficiently understood. The authors studied neural and subjective pain response in a randomized active-control trial of mindfulness-based stress reduction (MBSR) alongside long-term meditation practitioners.Methods:Healthy participants (N=115) underwent functional neuroimaging during a thermal acute pain task before and after random assignment… Continue reading Neural Signatures of Pain Modulation in Short-Term and Long-Term Mindfulness Training: A Randomized Active-Control Trial
Disentangling self from pain: mindfulness meditation-induced pain relief is driven by thalamic-default mode network decoupling
For millenniums, mindfulness was thought to diminish pain by reducing the influence of self-appraisals of noxious sensations. Today, mindfulness meditation is a highly popular and effective pain therapy that is thought to engage multiple, non-placebo related mechanisms to attenuate pain. Recent evidence suggests that mindfulness meditation-induced pain relief is associated with the engagement of unique… Continue reading Disentangling self from pain: mindfulness meditation-induced pain relief is driven by thalamic-default mode network decoupling
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