..Intervention: No screening; biennial or triennial mammography from age 50 to 75 years; annual mammography from age 50 to 75 years for women with dense breasts at age 50 years and biennial or triennial mammography from age 50 to 75 years for those without dense breasts at age 50 years; and annual mammography at age… Continue reading Incorporating Baseline Breast #Density When Screening Women at Average Risk for #Breast Cancer
Category: Oncology
#Ovarian cancer risk in relation to blood #lipid levels and hyperlipidemia: a systematic review and meta-analysis of observational epidemiologic studies
Epidemiologic evidence regarding association of ovarian cancer risk with blood lipid level and hyperlipidemia is inconsistent. We aimed to synthesize available epidemiologic studies to disentangle associations of cholesterol, triglycerides, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and hyperlipidemia with ovarian cancer risk. We searched PubMed, EMBASE, and Web of Science for eligible studies. A… Continue reading #Ovarian cancer risk in relation to blood #lipid levels and hyperlipidemia: a systematic review and meta-analysis of observational epidemiologic studies
#Nanoparticle-Mediated Delivery of 2-Deoxy-D-Glucose Induces Antitumor Immunity and Cytotoxicity in #Liver Tumors in Mice
Immune checkpoint inhibitors have shed light on the importance of antitumor immunity as a therapeutic strategy for hepatocellular carcinoma (HCC). The altered glucose metabolism known as the Warburg effect recently has gained attention as a cancer immune-resistance mechanism. Considering glycolysis inhibitors as therapeutic agents, their specific delivery to cancer cells is critical not to induce… Continue reading #Nanoparticle-Mediated Delivery of 2-Deoxy-D-Glucose Induces Antitumor Immunity and Cytotoxicity in #Liver Tumors in Mice
Drug-specific and dosage effects of #statins and the risk of #cancer: a population-based cohort study in South Korea
This study aimed to investigate whether the drug-specific and dosage effects of statin use were associated with a lower risk of cancer in adults in South Korea. We evaluated the adult population registered in the 2010 sample cohort database of South Korea. Subjects were divided into the statin group (those who had been prescribed continuous… Continue reading Drug-specific and dosage effects of #statins and the risk of #cancer: a population-based cohort study in South Korea
Fecal #microbiota transplant overcomes resistance to anti–PD-1 therapy in #melanoma patients
Anti–programmed cell death protein 1 (PD-1) therapy provides long-term clinical benefits to patients with advanced melanoma. The composition of the gut microbiota correlates with anti–PD-1 efficacy in preclinical models and cancer patients. To investigate whether resistance to anti–PD-1 can be overcome by changing the gut microbiota, this clinical trial evaluated the safety and efficacy of… Continue reading Fecal #microbiota transplant overcomes resistance to anti–PD-1 therapy in #melanoma patients
Time-restricted #feeding normalizes hyperinsulinemia to inhibit #breast cancer in obese postmenopausal mouse models
Accumulating evidence indicates that obesity with its associated metabolic dysregulation, including hyperinsulinemia and aberrant circadian rhythms, increases the risk for a variety of cancers including postmenopausal breast cancer. Caloric restriction can ameliorate the harmful metabolic effects of obesity and inhibit cancer progression but is difficult to implement and maintain outside of the clinic. In this… Continue reading Time-restricted #feeding normalizes hyperinsulinemia to inhibit #breast cancer in obese postmenopausal mouse models
Individualizing Surveillance #Mammography for Older Patients After Treatment for Early-Stage #Breast Cancer Multidisciplinary Expert Panel and International Society of Geriatric Oncology Consensus Statement
..After a literature review of the risk of ipsilateral and contralateral breast cancer events among breast cancer survivors and the harms and benefits associated with mammography, a multidisciplinary expert panel was convened to develop consensus guidelines on surveillance mammography for breast cancer survivors 75 years or older. Using an iterative consensus-based approach, input from clinician… Continue reading Individualizing Surveillance #Mammography for Older Patients After Treatment for Early-Stage #Breast Cancer Multidisciplinary Expert Panel and International Society of Geriatric Oncology Consensus Statement
#Benzophenone-3 promotion of mammary tumorigenesis is diet-dependent
Benzophenone-3 is a putative endocrine disrupting chemical and common ingredient in sunscreens. The potential of endocrine disrupting chemicals to act as agonists or antagonists in critical hormonally regulated processes, such as mammary gland development and mammary tumorigenesis, demands evaluation of its potential in promoting breast cancer. This study identifies the effects of BP-3 on mammary… Continue reading #Benzophenone-3 promotion of mammary tumorigenesis is diet-dependent
#Coffee consumption and risk of #prostate cancer: a systematic review and meta-analysis
To conduct a systematic review with meta-analysis of cohort studies to evaluate the association of coffee consumption with the risk of prostate cancer.. ..Sixteen prospective cohort studies were finally included, with 57 732 cases of prostate cancer and 1 081 586 total cohort members. Higher coffee consumption was significantly associated with a lower risk of prostate cancer. Compared… Continue reading #Coffee consumption and risk of #prostate cancer: a systematic review and meta-analysis
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