Chronic kidney disease (CKD) is a devastating progressive condition accompanied with high morbidity and mortality rates. Sodium-glucose cotransporter-2 (SGLT2) inhibitors have recently proven their renoprotective effects, whereas evidence for metformin remains limited but suggestive of potential benefit. This study aimed at comparing the efficacy and safety of metformin versus empagliflozin, a SGLT2 inhibitor, on retarding… Continue reading Efficacy and safety of #metformin versus #empagliflozin on chronic #kidney disease progression (MET-EMPA-CKD): a randomized controlled trial
Category: Nephrology
Saline and #N-acetylcysteine based strategies and other approaches to prevent the risk of CA- #AKI: a meta-analysis
AbstractBackground: While hydration is currently the most evidence-supported strategy for preventing contrast-associated acute kidney injury (CA-AKI) in patients undergoing cardiovascular angiography, the potential benefits of combining a saline and N-acetylcysteine (NAC) based strategy with additional pharmacologic interventions remain uncertain.Methods: We conducted a search for randomized controlled trials (RCTs) in PubMed, Embase, and the Cochrane library… Continue reading Saline and #N-acetylcysteine based strategies and other approaches to prevent the risk of CA- #AKI: a meta-analysis
Propagation of pathologic α-synuclein from #kidney to brain may contribute to #Parkinson’s disease
The pathogenesis of Lewy body diseases (LBDs), including Parkinson’s disease (PD), involves α-synuclein (α-Syn) aggregation that originates in peripheral organs and spreads to the brain. PD incidence is increased in individuals with chronic renal failure, but the underlying mechanisms remain unknown. Here we observed α-Syn deposits in the kidneys of patients with LBDs and in… Continue reading Propagation of pathologic α-synuclein from #kidney to brain may contribute to #Parkinson’s disease
Acute #Kidney Injury and Its Association With #Dementia and Specific Dementia Types
Background and ObjectivesPreclinical studies suggest that acute kidney injury (AKI) results in biochemical and pathologic changes in the brain. We aimed to explore the association between experiencing AKI and subsequent risks of developing dementia.MethodsWe conducted a study involving individuals aged 65 years and older in Stockholm from 2006 to 2019, who were free from dementia… Continue reading Acute #Kidney Injury and Its Association With #Dementia and Specific Dementia Types
#Ketogenic diet induces p53-dependent cellular #senescence in multiple organs
A ketogenic diet (KD) is a high-fat, low-carbohydrate diet that leads to the generation of ketones. While KDs improve certain health conditions and are popular for weight loss, detrimental effects have also been reported. Here, we show mice on two different KDs and, at different ages, induce cellular senescence in multiple organs, including the heart… Continue reading #Ketogenic diet induces p53-dependent cellular #senescence in multiple organs
#Metformin and Its Benefits for Various Diseases
Metformin is a widely used biguanide drug due to its safety and low cost. It has been used for over 60 years to treat type 2 diabetes at the early stages because of its outstanding ability to decrease plasma glucose levels. Over time, different uses of metformin were discovered, and the benefits of metformin for… Continue reading #Metformin and Its Benefits for Various Diseases
Downregulation of the kidney #glucagon receptor, essential for #renal function and systemic homeostasis, contributes to chronic kidney disease
The glucagon receptor (GCGR) in the kidney is expressed in nephron tubules. In humans and animal models with chronic kidney disease, renal GCGR expression is reduced. However, the role of kidney GCGR in normal renal function and in disease development has not been addressed. Here, we examined its role by analyzing mice with constitutive or conditional kidney-specific loss of the Gcgr. Adult renal Gcgr knockout mice exhibit metabolic dysregulation and a functional… Continue reading Downregulation of the kidney #glucagon receptor, essential for #renal function and systemic homeostasis, contributes to chronic kidney disease
Self-Reported Frequency of Adding #Salt to Food and Risk of Incident Chronic #Kidney Disease
Importance The self-reported frequency of adding salt to foods could reflect a person’s long-term salt taste preference, and salt intake has been associated with increased risk of cardiovascular diseases (CVD). Whether self-reported adding of salt to foods is associated with increased risk of chronic kidney disease (CKD) remains unknown.Objective To prospectively examine the association of self-reported frequency… Continue reading Self-Reported Frequency of Adding #Salt to Food and Risk of Incident Chronic #Kidney Disease
Short Oral Antibiotic Therapy for Pediatric Febrile #Urinary Tract Infections: A Randomized Trial
Febrile urinary tract infection (fUTI) in well-appearing children is conventionally treated with a standard 10-day course of oral antibiotic. The objective of this study is to determine the noninferiority (5% threshold) of a 5-day amoxicillin-clavulanate course compared with a 10-day regimen to treat fUTIs.METHODSThis is a multicenter, investigator-initiated, parallel-group, randomized, controlled trial. We randomly assigned… Continue reading Short Oral Antibiotic Therapy for Pediatric Febrile #Urinary Tract Infections: A Randomized Trial
2 Medical News 