Large-scale COVID-19 vaccinations are currently underway in many countries in response to the COVID-19 pandemic. Here, we report, besides generation of neutralizing antibodies, consistent alterations in hemoglobin A1c, serum sodium and potassium levels, coagulation profiles, and renal functions in healthy volunteers after vaccination with an inactivated SARS-CoV-2 vaccine. Similar changes had also been reported in… Continue reading Comprehensive investigations revealed consistent pathophysiological alterations after vaccination with COVID-19 vaccines
Category: Infectivology
Efficacy of Ceftazidime and Cefepime in the Management of COVID-19 Patients: Single Center Report from Egypt
AbstractThe purpose of this study was to explore the value of using cefepime and ceftazidime in treating patients with COVID-19. A total of 370 (162 males) patients, with RT-PCR-confirmed cases of COVID-19, were included in the study. Out of them, 260 patients were treated with cefepime or ceftazidime, with the addition of steroids to the… Continue reading Efficacy of Ceftazidime and Cefepime in the Management of COVID-19 Patients: Single Center Report from Egypt
Gut Ruminococcaceae levels at baseline correlate with risk of antibiotic-associated diarrhea
Highlights•Antibiotic-associated diarrhea (AAD) affects a significant proportion of patients•13/30 healthy volunteers who received oral amoxicillin-clavulanate developed AAD•Individuals who developed AAD had lower levels of gut Ruminococcaceae at baseline•Baseline levels of Faecalibacterium prausnitzii were predictive of risk of AAD SummaryAntibiotic-associated diarrhea (AAD) affects a significant proportion of patients receiving antibiotics. We sought to understand if differences… Continue reading Gut Ruminococcaceae levels at baseline correlate with risk of antibiotic-associated diarrhea
SARS-CoV-2 vaccines: Lights and shadows
Highglights• So far, vaccines to prevent SARS-CoV-2 infection appear as promising approach for curbing the pandemic. • Vaccines for SARS-CoV-2 are being developed using several different platforms. • Some concerns have been raised regarding the safety of SARS-CoV-2 vaccines on the basis of rare adverse reactions, particularly thromboembolic. • The applicability to the real life… Continue reading SARS-CoV-2 vaccines: Lights and shadows
School closure and management practices during coronavirus outbreaks including COVID-19: a rapid systematic review
In response to the coronavirus disease 2019 (COVID-19) pandemic, 107 countries had implemented national school closures by March 18, 2020. It is unknown whether school measures are effective in coronavirus outbreaks (eg, due to severe acute respiratory syndrome [SARS], Middle East respiratory syndrome, or COVID-19). We undertook a systematic review by searching three electronic databases… Continue reading School closure and management practices during coronavirus outbreaks including COVID-19: a rapid systematic review
Adolescent psychiatric disorders during the COVID-19 pandemic and lockdown
Highlights•The COVID-19 pandemic and lockdown may have a negative impact on the mental health of adolescents. •Epidemics and disasters are associated with adolescent Post Traumatic Stress, Depression, and Anxiety symptoms. •Healthcare system adaptations are necessary for mental health support despite the lockdown. •Home confinement may be associated with increased intrafamilial violence. •Data is scarce on… Continue reading Adolescent psychiatric disorders during the COVID-19 pandemic and lockdown
Prevalence and Durability of SARS-CoV-2 Antibodies Among Unvaccinated US Adults by History of COVID-19
As of December 28, 2021, approximately 27% of the US population was unvaccinated against SARS-CoV-2,1 yet the prevalence of natural immunity remains unknown. Blood donor studies may have selection bias and lack clinical information.2 Previous COVID-19 infection is a possible surrogate for natural immunity, but 1 study suggested that 36% of COVID-recovered individuals are serologic… Continue reading Prevalence and Durability of SARS-CoV-2 Antibodies Among Unvaccinated US Adults by History of COVID-19
Pre-infection 25-hydroxyvitamin D3 levels and association with severity of COVID-19 illness
Studies have demonstrated a potential correlation between low vitamin D status and both an increased risk of infection with SARS-CoV-2 and poorer clinical outcomes. This retrospective study examines if, and to what degree, a relationship exists between pre-infection serum 25-hydroxyvitamin D (25(OH)D) level and disease severity and mortality due to SARS-CoV-2. ParticipantsThe records of individuals… Continue reading Pre-infection 25-hydroxyvitamin D3 levels and association with severity of COVID-19 illness
A LITERATURE REVIEW AND META-ANALYSISOF THE EFFECTS OF LOCKDOWNS ONCOVID-19 MORTALITY
This systematic review and meta-analysis are designed to determine whether there is empiricalevidence to support the belief that “lockdowns” reduce COVID-19 mortality. Lockdowns aredefined as the imposition of at least one compulsory, non-pharmaceutical intervention (NPI).NPIs are any government mandate that directly restrict peoples’ possibilities, such as policies thatlimit internal movement, close schools and businesses, and… Continue reading A LITERATURE REVIEW AND META-ANALYSISOF THE EFFECTS OF LOCKDOWNS ONCOVID-19 MORTALITY
2 Medical News 