Gut #microbiota depletion by chronic #antibiotic treatment alters the sleep/wake architecture and #sleep EEG power spectra in mice

Dysbiosis of the gut microbiota affects physiological processes, including brain functions, by altering the intestinal metabolism. Here we examined the effects of the gut microbiota on sleep/wake regulation. C57BL/6 male mice were treated with broad-spectrum antibiotics for 4 weeks to deplete their gut microbiota. Metabolome profiling of cecal contents in antibiotic-induced microbiota-depleted (AIMD) and control mice showed significant variations in the metabolism of amino acids … Continue reading Gut #microbiota depletion by chronic #antibiotic treatment alters the sleep/wake architecture and #sleep EEG power spectra in mice

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Characterizing #COVID-19 and #Influenza Illnesses in the Real World via Person-Generated Health Data

The fight against COVID-19 is hindered by similarly presenting viral infections that may confound detection and monitoring. We examined Person-generated Health Data (PGHD), consisting of survey and commercial wearable data from individuals’ everyday lives, for 230 people who reported a COVID-19 diagnosis between 2020-03-30 and 2020-04-27 (N=41 with wearable data). Compared to self-reported diagnosed flu cases from the same timeframe (N=426, 85 with wearable data) … Continue reading Characterizing #COVID-19 and #Influenza Illnesses in the Real World via Person-Generated Health Data

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The #Coronavirus Is Mutating. What Does That Mean for Us?

By Apoorva Mandavilli – NYT Just as vaccines begin to offer hope for a path out of the pandemic, officials in Britain this past weekend sounded an urgent alarm about what they called a highly contagious new variant of the coronavirus circulating in England. Citing the rapid spread of the virus through London and surrounding areas, Prime Minister Boris Johnson imposed the country’s most stringent … Continue reading The #Coronavirus Is Mutating. What Does That Mean for Us?

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#Neutrophil more than #platelet activation associates with #thrombotic complications in #COVID-19 patients

SARS-CoV-2 infection is associated with hypercoagulability which predisposes to venous thromboembolism (VTE). We analyzed platelet and neutrophil activation in COVID-19 patients and their association with VTE. Methods Hospitalized COVID-19 patients and age- and sex-matched healthy controls were studied. Platelet and leukocyte activation, neutrophil extracellular traps (NETs), and matrix metalloproteinase-9 (MMP-9), a neutrophil-released enzyme, were measured. Four patients were re-studied after recovery. The activating effect of … Continue reading #Neutrophil more than #platelet activation associates with #thrombotic complications in #COVID-19 patients

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#UV-LED disinfection of #Coronavirus: Wavelength effect

UV light-emitting diodes (UV LEDs) are an emerging technology and a UV source for pathogen inactivation, however low UV-LED wavelengths are costly and have low fluence rate. Our results suggest that the sensitivity of human Coronavirus (HCoV-OC43 used as SARS-CoV-2 surrogate) was wavelength dependent with 267 nm ~ 279 nm > 286 nm > 297 nm. Other viruses showed similar results, suggesting UV LED with … Continue reading #UV-LED disinfection of #Coronavirus: Wavelength effect

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Effectiveness of #Prone Positioning in Nonintubated Intensive Care Unit Patients With Moderate to Severe Acute Respiratory Distress Syndrome by #Coronavirus Disease 2019

In the treatment for severe acute respiratory distress syndrome (ARDS) from coronavirus disease 2019 (COVID-19), the World Health Organization (WHO) recommends prone positioning (PP) during mechanical ventilation for periods of 12–16 h/d to potentially improve oxygenation and survival. In this prospective observational study, we evaluated the ability of long PP sessions to improve oxygenation in awake intensive care unit (ICU) patients with moderate or severe … Continue reading Effectiveness of #Prone Positioning in Nonintubated Intensive Care Unit Patients With Moderate to Severe Acute Respiratory Distress Syndrome by #Coronavirus Disease 2019

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Evaluation of Cloth #Masks and Modified Procedure Masks as Personal Protective Equipment for the Public During the #COVID-19 Pandemic

..To evaluate the fitted filtration efficiency (FFE) of various consumer-grade and improvised face masks, as well as several popular modifications of medical procedure masks that are intended to improve mask fit or comfort. Design, Setting, and Participants For this study conducted in a research laboratory between June and August 2020, 7 consumer-grade masks and 5 medical procedure mask modifications were fitted on an adult male … Continue reading Evaluation of Cloth #Masks and Modified Procedure Masks as Personal Protective Equipment for the Public During the #COVID-19 Pandemic

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A global survey of potential acceptance of a #COVID-19 vaccine

Several coronavirus disease 2019 (COVID-19) vaccines are currently in human trials. In June 2020, we surveyed 13,426 people in 19 countries to determine potential acceptance rates and factors influencing acceptance of a COVID-19 vaccine. Of these, 71.5% of participants reported that they would be very or somewhat likely to take a COVID-19 vaccine, and 61.4% reported that they would accept their employer’s recommendation to do … Continue reading A global survey of potential acceptance of a #COVID-19 vaccine

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#COVID-19 #Symptoms: Longitudinal Evolution and Persistence in Outpatient Settings

..Discussion: Coronavirus disease 2019 can persist and result in prolonged illness. Our study shows persistence of symptoms in a third of ambulatory patients 30 to 45 days after diagnosis even if we assume that those lost to follow-up were all asymptomatic. Fatigue, dyspnea, and loss of taste or smell were the main persistent symptoms. These results are in line with a recent study of 274 … Continue reading #COVID-19 #Symptoms: Longitudinal Evolution and Persistence in Outpatient Settings

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#IgA dominates the early neutralizing antibody response to #SARS-CoV-2

Abstract Humoral immune responses are typically characterized by primary IgM antibody responses followed by secondary antibody responses associated with immune memory and comprised of of IgG, IgA and IgE. Here we measured acute humoral responses to SARS-CoV-2, including the frequency of antibody-secreting cells and the presence of SARS-CoV-2-specific neutralizing antibodies in the serum, saliva and broncho-alveolar fluid of 159 patients with COVID-19. Early SARS-CoV-2-specific humoral … Continue reading #IgA dominates the early neutralizing antibody response to #SARS-CoV-2

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Effects of #probiotics on gut #microbiota: mechanisms of intestinal immunomodulation and neuromodulation

Recent explorations of the human gut microbiota suggest that perturbations of microbial communities may increase predisposition to different disease phenotypes. Dietary nutrients may be converted into metabolites by intestinal microbes that serve as biologically active molecules affecting regulatory functions in the host. Probiotics may restore the composition of the gut microbiome and introduce beneficial functions to gut microbial communities, resulting in amelioration or prevention of … Continue reading Effects of #probiotics on gut #microbiota: mechanisms of intestinal immunomodulation and neuromodulation

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UK probes whether #COVID-19 vaccine caused #allergic reactions

LONDON (AP) — Britain’s medical regulator warned Wednesday that people with a history of serious allergic reactions shouldn’t get the COVID-19 vaccine from Pfizer and BioNTech, and investigators looked into whether two reactions on the first day of the U.K.’s vaccination program were linked to the shot. The advice was issued on a “precautionary basis,” and the people who had the reactions had recovered, said … Continue reading UK probes whether #COVID-19 vaccine caused #allergic reactions

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