Aerosol and Surface Stability of #SARS-CoV-2 as Compared with SARS-CoV-1

..SARS-CoV-2 remained viable in aerosols throughout the duration of our experiment (3 hours), with a reduction in infectious titer from 103.5 to 102.7 TCID50 per liter of air. This reduction was similar to that observed with SARS-CoV-1, from 104.3 to 103.5 TCID50 per milliliter (Figure 1A). SARS-CoV-2 was more stable on plastic and stainless steel than on copper and cardboard, and viable virus was detected … Continue reading Aerosol and Surface Stability of #SARS-CoV-2 as Compared with SARS-CoV-1

Antibiotic Use and Outcomes in Children in the Emergency Department With Suspected #Pneumonia

Antibiotic therapy is often prescribed for suspected community-acquired pneumonia (CAP) in children despite a lack of knowledge of causative pathogen. Our objective in this study was to investigate the association between antibiotic prescription and treatment failure in children with suspected CAP who are discharged from the hospital emergency department (ED).. ..Of 337 eligible children, 294 were matched on the basis of propensity score. There was … Continue reading Antibiotic Use and Outcomes in Children in the Emergency Department With Suspected #Pneumonia

Risk Factors Associated With Acute #Respiratory Distress Syndrome and Death in Patients With #Coronavirus Disease 2019 Pneumonia in Wuhan, China

Coronavirus disease 2019 (COVID-19) is an emerging infectious disease that was first reported in Wuhan, China, and has subsequently spread worldwide. Risk factors for the clinical outcomes of COVID-19 pneumonia have not yet been well delineated.. ..Of 201 patients, the median age was 51 years (interquartile range, 43-60 years), and 128 (63.7%) patients were men. Eighty-four patients (41.8%) developed ARDS, and of those 84 patients, … Continue reading Risk Factors Associated With Acute #Respiratory Distress Syndrome and Death in Patients With #Coronavirus Disease 2019 Pneumonia in Wuhan, China

Relationship between the ABO #Blood Group and the #COVID-19 Susceptibility

Detection of ABO blood groups, infection occurrence of SARS-CoV-2, and patient death RESULTS The ABO group in 3694 normal people in Wuhan showed a distribution of 32.16%, 24.90%, 9.10% and 33.84% for A, B, AB and O, respectively, versus the distribution of 37.75%, 26.42%, 10.03% and 25.80% for A, B, AB and O, respectively, in 1775 COVID-19 patients from Wuhan Jinyintan Hospital. The proportion of … Continue reading Relationship between the ABO #Blood Group and the #COVID-19 Susceptibility

Critical Care Utilization for the #COVID-19 Outbreak in Lombardy, Italy Early Experience and Forecast During an Emergency Response

On February 20, 2020, a patient in his 30s admitted to the intensive care unit (ICU) in Codogno Hospital (Lodi, Lombardy, Italy) tested positive for a new coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes coronavirus disease 2019 (COVID-19). He had a history of atypical pneumonia that was not responding to treatment, but he was not considered at risk for COVID-19 … Continue reading Critical Care Utilization for the #COVID-19 Outbreak in Lombardy, Italy Early Experience and Forecast During an Emergency Response

Clinical course and risk factors for mortality of adult inpatients with #COVID-19 in Wuhan, China: a retrospective cohort study

Since December, 2019, Wuhan, China, has experienced an outbreak of coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Epidemiological and clinical characteristics of patients with COVID-19 have been reported but risk factors for mortality and a detailed clinical course of illness, including viral shedding, have not been well described.. ..91 (48%) patients had a comorbidity, with hypertension being the … Continue reading Clinical course and risk factors for mortality of adult inpatients with #COVID-19 in Wuhan, China: a retrospective cohort study

Consistent Detection of 2019 Novel #Coronavirus in #Saliva

The 2019 novel coronavirus (2019-nCoV) was detected in the self-collected saliva of 91.7% (11/12) of patients. Serial saliva viral load monitoring generally showed a declining trend. Live virus was detected in saliva by viral culture. Saliva is a promising noninvasive specimen for diagnosis, monitoring, and infection control in patients with 2019-nCoV infection. https://bit.ly/399IDoR PDF file https://bit.ly/2Tg712K Continue reading Consistent Detection of 2019 Novel #Coronavirus in #Saliva

Pharmacologic Therapies in Patients With Exacerbation of Chronic #Obstructive #Pulmonary Disease: A Systematic Review With Meta-analysis

..Compared with placebo or management without antibiotics, antibiotics given for 3 to 14 days were associated with increased exacerbation resolution at the end of the intervention (odds ratio [OR], 2.03 [95% CI, 1.47 to 2.80]; moderate SOE) and less treatment failure at the end of the intervention (OR, 0.54 [CI, 0.34 to 0.86]; moderate SOE), independent of severity of exacerbations in out- and inpatients. Compared … Continue reading Pharmacologic Therapies in Patients With Exacerbation of Chronic #Obstructive #Pulmonary Disease: A Systematic Review With Meta-analysis

Abnormal Coagulation parameters are associated with poor prognosis in patients with novel #coronavirus #pneumonia

In the recent outbreak of novel coronavirus infection in Wuhan, China, significantly abnormal coagulation parameters in severe novel coronavirus pneumonia (NCP) cases were a concern.. Conventional coagulation results and outcomes of consecutive 183 patients with confirmed NCP in Tongji hospital were retrospectively analysed. Results The overall mortality was 11.5%, the non‐survivors revealed significantly higher D‐dimer and fibrin degradation product (FDP) levels, longer prothrombin time and … Continue reading Abnormal Coagulation parameters are associated with poor prognosis in patients with novel #coronavirus #pneumonia

#Influenza #vaccine effectiveness 2019-2020 interim estimates

Annual vaccination against seasonal influenza is recommended for all U.S. persons aged ≥6 months. Effectiveness of seasonal influenza vaccine varies by season. What is added by this report? According to data from the U.S. Influenza Vaccine Effectiveness Network on 4,112 children and adults with acute respiratory illness during October 23, 2019–January 25, 2020, the overall estimated effectiveness of seasonal influenza vaccine for preventing medically attended, … Continue reading #Influenza #vaccine effectiveness 2019-2020 interim estimates

Empirical Anti-#MRSA vs Standard Antibiotic Therapy and Risk of 30-Day Mortality in Patients Hospitalized for #Pneumonia

..Compared with standard therapy alone, in weighted propensity score analysis, empirical anti-MRSA therapy plus standard therapy was significantly associated with an increased adjusted risk of death (adjusted risk ratio [aRR], 1.4 [95% CI, 1.3-1.5]), kidney injury (aRR, 1.4 [95% CI, 1.3-1.5]), and secondary C difficile infections (aRR, 1.6 [95% CI, 1.3-1.9]), vancomycin-resistant Enterococcus spp infections (aRR, 1.6 [95% CI, 1.0-2.3]), and secondary gram-negative rod infections … Continue reading Empirical Anti-#MRSA vs Standard Antibiotic Therapy and Risk of 30-Day Mortality in Patients Hospitalized for #Pneumonia