The ability to record high-quality electrophysiology data from the gastrointestinal tract and enteric nervous system is of use in understanding a variety of disorders and improving healthcare via early diagnosis. However, such measurements remain challenging because electrodes must be implanted surgically or worn on the skin, which results in a trade-off between signal quality and… Continue reading An ingestible device for #gastric electrophysiology
Category: Gastroenterology
Divergent age-associated and metabolism-associated gut #microbiome signatures modulate #cardiovascular disease risk
Insight into associations between the gut microbiome with metabolism and aging is crucial for tailoring interventions to promote healthy longevity. In a discovery cohort of 10,207 individuals aged 40–93 years, we used 21 metabolic parameters to classify individuals into five clusters, termed metabolic multimorbidity clusters (MCs), that represent different metabolic subphenotypes. Compared to the cluster classified… Continue reading Divergent age-associated and metabolism-associated gut #microbiome signatures modulate #cardiovascular disease risk
Mitochondrial ACSS1-K635 acetylation knock-in mice exhibit altered metabolism, cell senescence, and nonalcoholic fatty #liver disease
Acetyl-CoA synthetase short-chain family member 1 (ACSS1) uses acetate to generate mitochondrial acetyl-CoA and is regulated by deacetylation by sirtuin 3. We generated an ACSS1-acetylation (Ac) mimic mouse, where lysine-635 was mutated to glutamine (K635Q). Male Acss1K635Q/K635Q mice were smaller with higher metabolic rate and blood acetate and decreased liver/serum ATP and lactate levels. After a 48-hour… Continue reading Mitochondrial ACSS1-K635 acetylation knock-in mice exhibit altered metabolism, cell senescence, and nonalcoholic fatty #liver disease
The landscape of rare genetic variation associated with inflammatory #bowel disease and #Parkinson’s disease comorbidity
BackgroundInflammatory bowel disease (IBD) and Parkinson’s disease (PD) are chronic disorders that have been suggested to share common pathophysiological processes. LRRK2 has been implicated as playing a role in both diseases. Exploring the genetic basis of the IBD-PD comorbidity through studying high-impact rare genetic variants can facilitate the identification of the novel shared genetic factors underlying this… Continue reading The landscape of rare genetic variation associated with inflammatory #bowel disease and #Parkinson’s disease comorbidity
Safety and efficacy of faecal #microbiota transplantation in patients with mild to moderate #Parkinson’s disease (GUT-PARFECT): a double-blind, placebo-controlled, randomised, phase 2 trial
Dysregulation of the gut microbiome has been implicated in Parkinson's disease (PD). This study aimed to evaluate the clinical effects and safety of a single faecal microbiota transplantation (FMT) in patients with early-stage PD.MethodsThe GUT-PARFECT trial, a single-centre randomised, double-blind, placebo-controlled trial was conducted at Ghent University Hospital between December 01, 2020 and December 12,… Continue reading Safety and efficacy of faecal #microbiota transplantation in patients with mild to moderate #Parkinson’s disease (GUT-PARFECT): a double-blind, placebo-controlled, randomised, phase 2 trial
Risk Factors and Incidence of #Gastric #Cancer After Detection of #Helicobacter pylori Infection: A Large Cohort Study
Risk Factors and Incidence of Gastric Cancer After Detection of Helicobacter pylori Infection: A Large Cohort StudyShria KumarDavid C. MetzSusan EllenbergDavid E. KaplanDavid S. Goldberg Published:October 22, 2019DOI:https://doi.org/10.1053/j.gastro.2019.10.019PlumX MetricsBackground & AimsNearly all studies of gastric adenocarcinoma in the United States have relied on national cancer databases, which do not include data on Helicobacter pylori infection, the most well-known risk factor… Continue reading Risk Factors and Incidence of #Gastric #Cancer After Detection of #Helicobacter pylori Infection: A Large Cohort Study
Gut #microbiome and metabolome profiling in Framingham heart study reveals #cholesterol-metabolizing bacteria
Multi-omic profiling in FHS reveals microbes and metabolites associated with CVD•Oscillibacter species are associated with decreased blood and stool cholesterol•Homology searches and molecular networking predict cholesterol enzymes and products•Oscillibacter species encode for conserved cholesterol-metabolizing enzymesSummaryAccumulating evidence suggests that cardiovascular disease (CVD) is associated with an altered gut microbiome. Our understanding of the underlying mechanisms has been hindered… Continue reading Gut #microbiome and metabolome profiling in Framingham heart study reveals #cholesterol-metabolizing bacteria
Opposing diet, #microbiome, and metabolite mechanisms regulate inflammatory #bowel disease in a genetically susceptible host
Highlights•Dietary fiber-deprived gut microbiota elicits lethal colitis in Il10−/− mice•Mucolytic gut bacteria weaken mucus and drive inflammatory immune responses•Alterations in bacterial IgA coating and increased NK cells precede inflammation•Exclusive enteral nutrition promotes bacterial isobutyrate, reducing inflammationSummaryInflammatory bowel diseases (IBDs) are chronic conditions characterized by periods of spontaneous intestinal inflammation and are increasing in industrialized populations. Combined with… Continue reading Opposing diet, #microbiome, and metabolite mechanisms regulate inflammatory #bowel disease in a genetically susceptible host
Effect of #gut #microbiome modulation on #muscle function and #cognition: the PROMOTe randomised controlled trial
Studies suggest that inducing gut microbiota changes may alter both muscle physiology and cognitive behaviour. Gut microbiota may play a role in both anabolic resistance of older muscle, and cognition. In this placebo controlled double blinded randomised controlled trial of 36 twin pairs (72 individuals), aged ≥60, each twin pair are block randomised to receive… Continue reading Effect of #gut #microbiome modulation on #muscle function and #cognition: the PROMOTe randomised controlled trial
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