We aimed to investigate the mortality and hospital utilization outcomes of hospitalized nonalcoholic steatohepatitis (NASH) patients with and without kidney failure in a nationwide cohort.. ..The overall sample included 7,135,090 patients. Among 6855 patients admitted for NASH, 598 or 8.7% had comorbid kidney failure. After multivariate regression analysis, NASH patients with renal failure had increased… Continue reading #Renal Failure is Associated With Increased Mortality and Hospital Utilization in Patients Admitted With Nonalcoholic #Steatohepatitis
Category: Gastroenterology
Organ-specific, multimodal, wireless optoelectronics for high-throughput phenotyping of peripheral neural pathways
The vagus nerve supports diverse autonomic functions and behaviors important for health and survival. To understand how specific components of the vagus contribute to behaviors and long-term physiological effects, it is critical to modulate their activity with anatomical specificity in awake, freely behaving conditions using reliable methods. Here, we introduce an organ-specific scalable, multimodal, wireless… Continue reading Organ-specific, multimodal, wireless optoelectronics for high-throughput phenotyping of peripheral neural pathways
AGA Clinical Practice Update on Medical Management of Colonic #Diverticulitis: Expert Review
Colonic diverticulitis is a painful gastrointestinal disease that recurs unpredictably and can lead to chronic gastrointestinal symptoms. Gastroenterologists commonly care for patients with this disease. The purpose of this Clinical Practice Update is to provide practical and evidence-based advice for management of diverticulitis. We reviewed systematic reviews, meta-analyses, randomized controlled trials, and observational studies to… Continue reading AGA Clinical Practice Update on Medical Management of Colonic #Diverticulitis: Expert Review
Advanced #Liver Fibrosis Is Common in Patients With Type 2 #Diabetes Followed in the Outpatient Setting: The Need for Systematic Screening
Assess the prevalence of nonalcoholic fatty liver disease (NAFLD) and of liver fibrosis associated with nonalcoholic steatohepatitis in unselected patients with type 2 diabetes mellitus (T2DM). A total of 561 patients with T2DM (age: 60 ± 11 years; BMI: 33.4 ± 6.2 kg/m2; and HbA1c: 7.5 ± 1.8%) attending primary care or endocrinology outpatient clinics… Continue reading Advanced #Liver Fibrosis Is Common in Patients With Type 2 #Diabetes Followed in the Outpatient Setting: The Need for Systematic Screening
#Endoscopy-related #bleeding and thromboembolic events in patients on direct oral anticoagulants or vitamin K antagonists
Few prospective studies have assessed the safety of direct oral anticoagulants (DOACs) in elective endoscopy. Our primary aim was to compare the risks of endoscopy-related gastrointestinal bleeding and thromboembolic events in patients on DOACs or vitamin K antagonists (VKAs) in this setting. Secondarily, we examined the impact of the timing of anticoagulant resumption on the… Continue reading #Endoscopy-related #bleeding and thromboembolic events in patients on direct oral anticoagulants or vitamin K antagonists
#Avocado Consumption Alters Gastrointestinal #Bacteria Abundance and Microbial Metabolite Concentrations among Adults with Overweight or #Obesity: A Randomized Controlled Trial
Avocados are rich in dietary fiber and monounsaturated fatty acids (MUFAs), nutrients that have been independently connected to metabolic health benefits and the gastrointestinal microbiota. Objectives We aimed to evaluate the impact of avocado consumption on the gastrointestinal microbiota and microbial metabolites, secondary outcomes of the Persea americana for Total Health (PATH) study, and conduct… Continue reading #Avocado Consumption Alters Gastrointestinal #Bacteria Abundance and Microbial Metabolite Concentrations among Adults with Overweight or #Obesity: A Randomized Controlled Trial
Elevated ectodomain of type 23 #collagen is a novel biomarker of the intestinal epithelium to monitor disease activity in #ulcerative colitis and #Crohn’s disease
Impaired intestinal epithelial barrier is highly affected in inflammatory bowel disease. Transmembrane collagens connecting the epithelial cells to the extracellular matrix have an important role in epithelial cell homeostasis. Thus, we sought to determine whether the transmembrane type 23 collagen could serve as a surrogate marker for disease activity in patients with Crohn’s disease and… Continue reading Elevated ectodomain of type 23 #collagen is a novel biomarker of the intestinal epithelium to monitor disease activity in #ulcerative colitis and #Crohn’s disease
Gut #microbiota depletion by chronic #antibiotic treatment alters the sleep/wake architecture and #sleep EEG power spectra in mice
Dysbiosis of the gut microbiota affects physiological processes, including brain functions, by altering the intestinal metabolism. Here we examined the effects of the gut microbiota on sleep/wake regulation. C57BL/6 male mice were treated with broad-spectrum antibiotics for 4 weeks to deplete their gut microbiota. Metabolome profiling of cecal contents in antibiotic-induced microbiota-depleted (AIMD) and control… Continue reading Gut #microbiota depletion by chronic #antibiotic treatment alters the sleep/wake architecture and #sleep EEG power spectra in mice
The influence of #proton pump inhibitor therapy on the outcome of #infliximab therapy in inflammatory bowel disease: a patient-level meta-analysis of randomised controlled studies
In treating patients with inflammatory bowel disease (IBD), how concomitant medications influence the response to infliximab is largely unexplored. We aim to evaluate whether proton pump inhibitors (PPIs) affect the response to infliximab therapy in patients with IBD.. Among the five randomised controlled studies, there were 889 and 147 patients on infliximab with and without… Continue reading The influence of #proton pump inhibitor therapy on the outcome of #infliximab therapy in inflammatory bowel disease: a patient-level meta-analysis of randomised controlled studies
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