Highlights• Sugar-sweetened beverage intake was associated with nine gut bacteria abundances• These bacteria were correlated with aromatic and branched-chain amino acid metabolites• These bacteria were correlated with glycerophospholipids• These gut microbial metabolites were associated with diabetes risk SummaryNo population-based studies examined gut microbiota and related metabolites associated with sugar-sweetened beverage (SSB) intake among US adults.… Continue reading #Sugar-sweetened beverage intake, gut #microbiota, circulating metabolites, and #diabetes risk in Hispanic Community Health Study/Study of Latinos
Category: Endocrinology
Can #carbonated water support weight loss?
Background Carbonated water has been reported to induce satiety, gastric motility and lower serum glucose concentrations, but the mechanisms remain unclear.Methods This report explores the physiological effects of carbonated water, referencing a study published in 2004 on the mechanisms of hypoglycaemia induced by haemodialysis.Results Upon consumption of carbonated water, carbon dioxide (CO2) is absorbed into… Continue reading Can #carbonated water support weight loss?
#Dapagliflozin plus calorie restriction for remission of type 2 #diabetes: multicentre, double blind, randomised, placebo controlled trial
Objective To assess the effect of dapagliflozin plus calorie restriction on remission of type 2 diabetes.Design Multicentre, double blind, randomised, placebo controlled trial.Setting 16 centres in mainland China from 12 June 2020 to 31 January 2023.Participants 328 patients with type 2 diabetes aged 20-70 years, with body mass index >25 and diabetes duration of <6… Continue reading #Dapagliflozin plus calorie restriction for remission of type 2 #diabetes: multicentre, double blind, randomised, placebo controlled trial
Menopause-induced 17β-estradiol and progesterone loss increases senescence markers, matrix disassembly and degeneration in mouse #cartilage
Female individuals who are post-menopausal present with higher incidence of knee osteoarthritis (KOA) than male counterparts; however, the mechanisms underlying this disparity are unknown. The most commonly used preclinical models lack human-relevant menopausal phenotypes, which may contribute to our incomplete understanding of sex-specific differences in KOA pathogenesis. Here we chemically induced menopause in middle-aged (14–16… Continue reading Menopause-induced 17β-estradiol and progesterone loss increases senescence markers, matrix disassembly and degeneration in mouse #cartilage
Definition and diagnostic criteria of clinical #obesity
Current BMI-based measures of obesity can both underestimate and overestimate adiposity and provide inadequate information about health at the individual level, which undermines medically-sound approaches to health care and policy. This Commission sought to define clinical obesity as a condition of illness that, akin to the notion of chronic disease in other medical specialties, directly… Continue reading Definition and diagnostic criteria of clinical #obesity
Awakening not associated with an increased rate of #cortisol secretion
Cortisol is released upon activation of the hypothalamic–pituitary–adrenal axis, varies across the day, possesses an underlying diurnal rhythm and is responsive to stressors. The endogenous circadian peak of cortisol occurs in the morning, and increases in cortisol observed post-awakening have been named the cortisol awakening response (CAR) based on the belief that the act of… Continue reading Awakening not associated with an increased rate of #cortisol secretion
Burdens of type 2 #diabetes and #cardiovascular disease attributable to sugar-sweetened beverages in 184 countries
The consumption of sugar-sweetened beverages (SSBs) is associated with type 2 diabetes (T2D) and cardiovascular diseases (CVD). However, an updated and comprehensive assessment of the global burden attributable to SSBs remains scarce. Here we estimated SSB-attributable T2D and CVD burdens across 184 countries in 1990 and 2020 globally, regionally and nationally, incorporating data from the… Continue reading Burdens of type 2 #diabetes and #cardiovascular disease attributable to sugar-sweetened beverages in 184 countries
Late #eating is associated with poor #glucose tolerance, independent of body weight, fat mass, energy intake and diet composition in prediabetes or early onset type 2 #diabetes
This study investigates the impact of habitual late calorie intake on glucose metabolism in adults with overweight or obesity and diet or metformin-controlled prediabetes or type 2 diabetes independently of body weight, fat mass, energy intake or diet composition. Participants (n = 26) were classified as Later Eaters (LE) if ≥45% daily calories were consumed after 5 pm… Continue reading Late #eating is associated with poor #glucose tolerance, independent of body weight, fat mass, energy intake and diet composition in prediabetes or early onset type 2 #diabetes
Screening for advanced #liver fibrosis due to metabolic dysfunction-associated #steatotic liver disease alongside #retina scanning in people with type 2 diabetes: a cross-sectional study
BackgroundInternational guidelines suggest screening for advanced fibrosis due to metabolic dysfunction-associated steatotic liver disease in people with type 2 diabetes, but how to implement these guidelines in clinical care remains unclear. We hypothesise that examination with VCTE could be implemented simultaneously with retina scanning with a high acceptance rate in people with type 2 diabetes.… Continue reading Screening for advanced #liver fibrosis due to metabolic dysfunction-associated #steatotic liver disease alongside #retina scanning in people with type 2 diabetes: a cross-sectional study
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