Urinary #tartaric acid as a biomarker of #wine consumption and #cardiovascular risk: the PREDIMED trial

Background and AimsModerate wine consumption has been associated with lower cardiovascular disease (CVD) risk in older populations. However, wine consumption information through self-reports is prone to measurement errors inherent to subjective assessments. The aim of this study was to evaluate the association between urinary tartaric acid, an objective biomarker of wine consumption, and the rate… Continue reading Urinary #tartaric acid as a biomarker of #wine consumption and #cardiovascular risk: the PREDIMED trial

Impact of #coffee intake on human #aging: Epidemiology and cellular mechanisms

Highlights•The regular consumption of moderate doses of coffee attenuates all-cause mortality•Coffee intake attenuates age-associated diseases (cardiovascular, stroke, cancer)•Coffee and its main components (caffeine, chlorogenic acids) control stress adaptation•Coffee intake preserves the main biological mechanisms of aging AbstractThe conception of coffee consumption has undergone a profound modification, evolving from a noxious habit into a safe lifestyle… Continue reading Impact of #coffee intake on human #aging: Epidemiology and cellular mechanisms

Added #sugar intake and its associations with incidence of seven different #cardiovascular diseases in 69,705 Swedish men and women

Introduction: The adverse health effects of sugar-sweetened beverage intake are well-established, but the implications of overall added sugar intake remain unclear. We investigated the associations between intake of added sugar and various sugar-sweetened foods and beverages and risk of 7 cardiovascular diseases in 69,705 participants aged 45–83 years (47.2% female) from the Swedish Mammography cohort… Continue reading Added #sugar intake and its associations with incidence of seven different #cardiovascular diseases in 69,705 Swedish men and women

#Chocolate intake and risk of type 2 #diabetes: prospective cohort studies

Objective To prospectively investigate the associations between dark, milk, and total chocolate consumption and risk of type 2 diabetes (T2D) in three US cohorts.Design Prospective cohort studies.Setting Nurses’ Health Study (NHS; 1986-2018), Nurses’ Health Study II (NHSII; 1991-2021), and Health Professionals Follow-Up Study (HPFS; 1986-2020).Participants At study baseline for total chocolate analyses (1986 for NHS… Continue reading #Chocolate intake and risk of type 2 #diabetes: prospective cohort studies

Dietary #fructose enhances #tumour growth indirectly via interorgan lipid transfer

Fructose consumption has increased considerably over the past five decades, largely due to the widespread use of high-fructose corn syrup as a sweetener1. It has been proposed that fructose promotes the growth of some tumours directly by serving as a fuel2,3. Here we show that fructose supplementation enhances tumour growth in animal models of melanoma,… Continue reading Dietary #fructose enhances #tumour growth indirectly via interorgan lipid transfer

#Coffee consumption is associated with intestinal #Lawsonibacter asaccharolyticus abundance and prevalence across multiple cohorts

Although diet is a substantial determinant of the human gut microbiome, the interplay between specific foods and microbial community structure remains poorly understood. Coffee is a habitually consumed beverage with established metabolic and health benefits. We previously found that coffee is, among >150 items, the food showing the highest correlation with microbiome components. Here we… Continue reading #Coffee consumption is associated with intestinal #Lawsonibacter asaccharolyticus abundance and prevalence across multiple cohorts

#Cocoa flavanols rescue #stress-induced declines in endothelial function after a high-fat meal, but do not affect cerebral oxygenation during stress in young, healthy adults

Food choices during stressful periods often worsen, which can influence the impact of stress on vascular health. For instance, fat consumption impairs the recovery of endothelial function following mental stress, while flavanols have been shown to enhance recovery. This randomised, counterbalanced, double-blinded, crossover, postprandial intervention study examined whether flavanols consumed in combination with fat can… Continue reading #Cocoa flavanols rescue #stress-induced declines in endothelial function after a high-fat meal, but do not affect cerebral oxygenation during stress in young, healthy adults

Non-fermented and fermented #milk intake in relation to risk of ischemic #heart disease and to circulating cardiometabolic proteins in swedish women and men: Two prospective longitudinal cohort studies with 100,775 participants

BackgroundThe effect of milk on the risk of ischemic heart disease (IHD) and acute myocardial infarction (MI) is unclear. We aimed to examine the association between non-fermented and fermented milk consumption on these endpoints and investigate the relationship between milk intake and cardiometabolic-related proteins in plasma.MethodsOur study is based on two Swedish prospective cohort studies… Continue reading Non-fermented and fermented #milk intake in relation to risk of ischemic #heart disease and to circulating cardiometabolic proteins in swedish women and men: Two prospective longitudinal cohort studies with 100,775 participants

Ultra-processed #food consumption is associated with the acceleration of biological #aging in the Moli-sani Study

BackgroundHealthy diets have been inversely associated with biological aging. However, the nutritional content is only one aspect of the overall food health potential, and more recently, increasing attention has been paid to nonnutrient food characteristics, such as food processing.ObjectivesTo examine the association of ultra-processed food (UPF) consumption with biological aging measured by circulating blood biomarkers.MethodsCross-sectional… Continue reading Ultra-processed #food consumption is associated with the acceleration of biological #aging in the Moli-sani Study