Background and ObjectivesHeavy alcohol consumption is a major global health concern linked to increased morbidity and mortality. However, the long-term impact of excessive alcohol consumption on cognitive abilities and dementia-related neuropathology is unclear. The aim of this study was to analyze the association between alcohol consumption and age-related neuropathologic outcomes in a population-based autopsy study.MethodsThis… Continue reading Association Between #Alcohol Consumption, #Cognitive Abilities, and Neuropathologic Changes
Category: Diet
Immune and metabolic effects of African heritage #diets versus Western diets in men: a randomized controlled trial
African heritage diets are increasingly being replaced by Western-style dietary patterns because of urbanization, economic development, increased access to processed foods, globalization and changing social norms. The health consequences of this nutrition transition are not well understood. We conducted a randomized controlled trial in the Kilimanjaro region in Northern Tanzania to investigate the immune and… Continue reading Immune and metabolic effects of African heritage #diets versus Western diets in men: a randomized controlled trial
Non-caloric #sweetener effects on brain appetite regulation in individuals across varying body #weights
Sucralose, a widely used non-caloric sweetener, provides sweet taste without calories. Some studies suggest that non-caloric sweeteners stimulate appetite, possibly owing to the delivery of a sweet taste without the post-ingestive metabolic signals that normally communicate with the hypothalamus to suppress hunger. In a randomized crossover trial (ClinicalTrials.gov identifier: NCT02945475), 75 young adults (healthy weight,… Continue reading Non-caloric #sweetener effects on brain appetite regulation in individuals across varying body #weights
High- #salt #diet drives depression-like behavior in mice by inducing IL-17A production
Major depression disorder is a common illness that severely limits psychosocial functioning, affects outcomes of other diseases, and diminishes the quality of life. High-salt diet (HSD) has long been closely associated with the occurrence and development of depression, but whether or how HSD causes depression remains unclear. In this study, HSD induces depression-like behavior in… Continue reading High- #salt #diet drives depression-like behavior in mice by inducing IL-17A production
The Effect of 4:3 Intermittent #Fasting on #Weight Loss at 12 Months: A Randomized Clinical Trial
AbstractBackground:Long-term (≥12 months) randomized trials evaluating the efficacy of intermittent fasting (IMF) as a dietary weight loss strategy are limited. Furthermore, no studies have compared IMF versus daily caloric restriction (DCR) when both interventions are provided in the context of a guidelines-based behavioral weight loss program.Objective:To compare the effects of 4:3 IMF versus DCR on… Continue reading The Effect of 4:3 Intermittent #Fasting on #Weight Loss at 12 Months: A Randomized Clinical Trial
Optimal #dietary patterns for healthy #aging
As the global population ages, it is critical to identify diets that, beyond preventing noncommunicable diseases, optimally promote healthy aging. Here, using longitudinal questionnaire data from the Nurses’ Health Study (1986–2016) and the Health Professionals Follow-Up Study (1986–2016), we examined the association of long-term adherence to eight dietary patterns and ultraprocessed food consumption with healthy… Continue reading Optimal #dietary patterns for healthy #aging
Association of 15 common dietary factors with #tinnitus: a systematic review and meta-analysis of observational studies
Objective A systematic analysis was conducted to investigate the association between tinnitus incidence and daily dietary patterns.Design We conducted a systematic review and meta-analysis of observational studies.Data sources The PubMed, Embase, Web of Science and Cochrane Library databases were searched from their inception to 25 May 2024.Eligibility criteria for selecting studies We included observational studies… Continue reading Association of 15 common dietary factors with #tinnitus: a systematic review and meta-analysis of observational studies
#Dietary fibre counters the oncogenic potential of colibactin-producing Escherichia coli in colorectal #cancer
Diet, microbiome, inflammation and host genetics have been linked to colorectal cancer development; however, it is not clear whether and how these factors interact to promote carcinogenesis. Here we used Il10−/− mice colonized with bacteria previously associated with colorectal cancer: enterotoxigenic Bacteroides fragilis, Helicobacter hepaticus or colibactin-producing (polyketide synthase-positive (pks+)) Escherichia coli and fed either… Continue reading #Dietary fibre counters the oncogenic potential of colibactin-producing Escherichia coli in colorectal #cancer
Association of #Diet and #Waist-to-Hip Ratio With Brain Connectivity and #Memory in #Aging
Importance Epidemiological studies suggest that lifestyle factors are associated with risk of dementia. However, few studies have examined the association of diet and waist to hip ratio (WHR) with hippocampus connectivity and cognitive health.Objective To ascertain how longitudinal changes in diet quality and WHR during midlife are associated with hippocampal connectivity and cognitive function in… Continue reading Association of #Diet and #Waist-to-Hip Ratio With Brain Connectivity and #Memory in #Aging
