Importance Older adults with lower intake and tissue levels of long-chain ω-3 polyunsaturated fatty acids (PUFAs) eicosapentaenoic acid (EPA; 20:5) and docosahexaenoic acid (DHA; 22:6) have more brain white matter lesions (WMLs), an association suggesting that small-vessel ischemic disease, a major contributor to the development of dementia, including Alzheimer disease, may be preventable through ω-3 treatment.Objective To… Continue reading ω-3 #PUFA for Secondary Prevention of White Matter Lesions and Neuronal Integrity Breakdown in Older AdultsA Randomized Clinical Trial
Category: Diet
Higher #Coffee Consumption Is Associated With Slower #Cognitive Decline and Less Cerebral Aβ-Amyloid Accumulation Over 126 Months: Data From the Australian Imaging, Biomarkers, and Lifestyle Study
AbstractBackground: Worldwide, coffee is one of the most popular beverages consumed. Several studies have suggested a protective role of coffee, including reduced risk of Alzheimer's disease (AD). However, there is limited longitudinal data from cohorts of older adults reporting associations of coffee intake with cognitive decline, in distinct domains, and investigating the neuropathological mechanisms underpinning any… Continue reading Higher #Coffee Consumption Is Associated With Slower #Cognitive Decline and Less Cerebral Aβ-Amyloid Accumulation Over 126 Months: Data From the Australian Imaging, Biomarkers, and Lifestyle Study
Brain responses to intermittent #fasting and the healthy living #diet in older adults
Highlights•8 weeks of 5:2 intermittent fasting caused more weight loss than healthy living diet•Both diets reduced neuronal insulin resistance and the pace of brain aging•Both diets improved memory and executive function, with 5:2 intermittent fasting more so•Biomarkers of Alzheimer’s disease did not change with either dietSummaryDiet may promote brain health in metabolically impaired older individuals. In… Continue reading Brain responses to intermittent #fasting and the healthy living #diet in older adults
Recipe for Heart Health: A Randomized Crossover Trial on Cardiometabolic Effects of Extra Virgin #Olive #Oil Within a Whole‐Food Plant‐Based Vegan #Diet
Whole‐food, plant‐based vegan diets, low in oils, and Mediterranean diets, rich in extra virgin olive oil (EVOO), reduce cardiovascular disease risk factors. Optimal quantity of dietary fat, particularly EVOO, is unclear.Methods and ResultsIn a randomized crossover trial with weekly cooking classes, adults with ≥5% cardiovascular disease risk followed a high (4 tablespoons/day) to low (<1 teaspoon/day)… Continue reading Recipe for Heart Health: A Randomized Crossover Trial on Cardiometabolic Effects of Extra Virgin #Olive #Oil Within a Whole‐Food Plant‐Based Vegan #Diet
Energy Intake and Dietary Glycemic Load in Late Morning and Risk of Type 2 #Diabetes: The Hispanic Community #Health Study/Study of #Latinos, a Multicenter Prospective Cohort Study
To evaluate the association between meal timing and type 2 diabetes risk in U.S. Hispanic/Latino adults.RESEARCH DESIGN AND METHODSThe Hispanic Community Health Study/Study of Latinos (HCHS/SOL) is a multicenter, community-based, prospective cohort study. This study included 8,868 HCHS/SOL adults without diabetes at baseline (2008–2011) and attending the visit 2 examination (2014–2017). Energy intake and glycemic… Continue reading Energy Intake and Dietary Glycemic Load in Late Morning and Risk of Type 2 #Diabetes: The Hispanic Community #Health Study/Study of #Latinos, a Multicenter Prospective Cohort Study
Impact of Plant-Based Dietary #Fibers on Metabolic Homeostasis in High-#Fat Diet Mice via Alterations in the Gut #Microbiota and Metabolites
BackgroundThe gut microbiota contributes to metabolic disease, and diet shapes the gut microbiota, emphasizing the need to better understand how diet impacts metabolic disease via gut microbiota alterations. Fiber intake is linked with improvements in metabolic homeostasis in rodents and humans, which is associated with changes in the gut microbiota. However, dietary fiber is extremely… Continue reading Impact of Plant-Based Dietary #Fibers on Metabolic Homeostasis in High-#Fat Diet Mice via Alterations in the Gut #Microbiota and Metabolites
Healthy Prenatal #Dietary Pattern and Offspring #Autism
Question What is the association between a healthy prenatal dietary pattern and offspring autism diagnosis and autism-associated traits in 2 large prospective cohort studies: the Norwegian Mother, Father, and Child Cohort (MoBa) and the Avon Study of Parents and Children (ALSPAC)?Findings In this cohort study including 84 548 mother-infant dyads in MoBa and 11 670 mother-infant dyads in ALSPAC,… Continue reading Healthy Prenatal #Dietary Pattern and Offspring #Autism
#Dried fruit intake and lower risk of type 2 #diabetes: a two-sample mendelian randomization study
BackgroundPrevious studies have shown controversy about whether dried fruit intake is associated with type 2 diabetes. This study aimed to examine the potential causal effect of dried fruit intake on type 2 diabetes by conducting a two-sample Mendelian randomization study.MethodsWe used genome-wide association study (GWAS) summary statistics for MR analysis to explore the causal association… Continue reading #Dried fruit intake and lower risk of type 2 #diabetes: a two-sample mendelian randomization study
#Diet shapes the metabolite profile in the intact human ileum, which affects PYY release
The human ileum contains a high density of enteroendocrine L-cells, which release the appetite-suppressing hormones glucagon-like peptide-1 (GLP-1) and peptide tyrosine tyrosine (PYY) in response to food intake. Recent evidence highlighted the potential role of food structures in PYY release, but the link between food structures, ileal metabolites, and appetite hormone release remains unclear owing… Continue reading #Diet shapes the metabolite profile in the intact human ileum, which affects PYY release
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