Chronic spontaneous #urticaria (CSU) is associated with a substantial disease burden due to its prolonged course and significant impairment of quality of life. The diagnostic process for #CSU involves confirming the diagnosis itself and identifying disease phenotypes or endotypes, cofactors, and comorbid conditions, which may affect disease activity and severity. Immunoglobulin E (IgE) and non-IgE-mediated… Continue reading Immunological Basis of Chronic Spontaneous Urticaria: Immunoglobulin E and Beyond
Category: allergy
Clinical Outcome Associated With Beta-Lactam Allergy Labels in Hospitalized Patients in Belgium
Background: In the United States, beta-lactam #allergy labels (BLAL) are documented in 9%-16% of hospitalized patients and associated with worse clinical outcomes such as increased mortality, length of hospital stay (LOS), intensive care unit (ICU) admission, and use of alternative antibiotics, providing an incentive for broad delabeling protocols. In Europe, BLAL prevalences are lower (0.6%-5%)… Continue reading Clinical Outcome Associated With Beta-Lactam Allergy Labels in Hospitalized Patients in Belgium
Multicentre, double-blind, randomized placebo-controlled trial to evaluate the therapeutic efficacy of #nutraceutical combination in the treatment of #allergic #rhinitis
BackgroundAllergic rhinitis (AR) is a widely diffused atopic disease that is hardly managed by conventional therapy, especially in the long-term. Fatty acids (FAs), which possess both anti-inflammatory and immunomodulatory properties, could be used to control AR symptoms.ObjectiveWe aimed at evaluating the benefits (efficacy in reducing symptoms and safety) of using an oral supplement containing FAs… Continue reading Multicentre, double-blind, randomized placebo-controlled trial to evaluate the therapeutic efficacy of #nutraceutical combination in the treatment of #allergic #rhinitis
Breast #milk IgG engages the mouse #neonatal #immune system to instruct responses to #gut #antigens
INTRODUCTIONIn mammals, the early-life period after birth is a time of profound immune development during which the generation of appropriate responses to newly encountered commensal and environmental antigens is crucial for maintaining health. Breast milk is positioned to regulate nascent mucosal immune responses through the delivery of live microbes, commensal-selecting oligosaccharides, maternal cells, and immunomodulatory… Continue reading Breast #milk IgG engages the mouse #neonatal #immune system to instruct responses to #gut #antigens
The effect of #camel #milk on house dust mite allergen induced #asthma model in BALB/C mice
Camel milk has demonstrated robust immunomodulatory and anti-inflammatory properties in various clinical and experimental studies. However, no previous studies have characterized the cellular immunological effects of camel milk in the context of allergic asthma. Therefore, the present work aimed to evaluate the protective effects of camel milk in house dust mite induced asthma in mice,… Continue reading The effect of #camel #milk on house dust mite allergen induced #asthma model in BALB/C mice
#Skin damage signals mediate #allergic sensitization to spatially unlinked antigen
Our current understanding of immunity to pathogens suggests that anatomic coupling of antigens with danger signals is a required feature for the formation of immune memory. However, in the context of pathogen-independent inflammation, the stringency of this anatomical coupling is unclear. Here, we demonstrate that multiple modes of skin injury were sufficient to induce a… Continue reading #Skin damage signals mediate #allergic sensitization to spatially unlinked antigen
#ATOPIC DERMATITIS PATIENT EXPERIENCE WITH DISCUSSING AND ADDRESSING MENTAL HEALTH CONCERNS WITH ALLERGISTS
Atopic dermatitis (AD) is the most common form of eczema and has a significant, multidimensional burden of disease. Patients with AD have an increased likelihood of developing depression and anxiety, which is exacerbated when additional atopic comorbidities are present. Little is known about the patient experience with discussing or addressing mental health concerns with their… Continue reading #ATOPIC DERMATITIS PATIENT EXPERIENCE WITH DISCUSSING AND ADDRESSING MENTAL HEALTH CONCERNS WITH ALLERGISTS
Guidelines of care for the management of atopic dermatitis in adults with topical therapies
BackgroundNew evidence has emerged since the 2014 guidelines that further informs the management of AD with topical therapies. These guidelines update the 2014 recommendations for management of atopic dermatitis (AD) with topical therapies.ObjectiveTo provide evidence-based recommendations related to management of AD in adults using topical treatments.MethodsA multidisciplinary workgroup conducted a systematic review and applied the… Continue reading Guidelines of care for the management of atopic dermatitis in adults with topical therapies
Prenatal antibiotic exposure, asthma and the atopic march: A systematic review and meta-analysis
BackgroundAntibiotic use during pregnancy may increase the risk for asthma in children. We performed a meta-analysis assessing prenatal antibiotic exposure and the risk for childhood wheeze or asthma, as well as for diseases associated with the atopic march. MethodsA systematic literature search protocol (PROSPERO-ID: CRD42020191940) was registered and searches were completed using Medline, Proquest, Embase,… Continue reading Prenatal antibiotic exposure, asthma and the atopic march: A systematic review and meta-analysis
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