ObjectivesTo determine the association between early midlife sleep and advanced brain aging patterns in late midlife.MethodsUsing the CARDIA study, we analyzed sleep data at baseline and 5 years later, focusing on short sleep duration, bad sleep quality (SQ), difficulty initiating and maintaining sleep (DIS and DMS), early morning awakening (EMA), and daytime sleepiness. These were… Continue reading Association of Self-Reported #Sleep Characteristics With Neuroimaging Markers of Brain #Aging Years Later in Middle-Aged Adults
Category: Aging
#Dietary restriction impacts health and #lifespan of genetically diverse mice
Caloric restriction extends healthy lifespan in multiple species1. Intermittent fasting, an alternative form of dietary restriction, is potentially more sustainable in humans, but its effectiveness remains largely unexplored2,3,4,5,6,7,8. Identifying the most efficacious forms of dietary restriction is key for developing interventions to improve human health and longevity9. Here we performed an extensive assessment of graded… Continue reading #Dietary restriction impacts health and #lifespan of genetically diverse mice
#CheekAge, a next-generation epigenetic buccal clock, is predictive of mortality in human blood
While earlier first-generation epigenetic aging clocks were trained to estimate chronological age as accurately as possible, more recent next-generation clocks incorporate DNA methylation information more pertinent to health, lifestyle, and/or outcomes. Recently, we produced a non-invasive next-generation epigenetic clock trained using Infinium MethylationEPIC data from more than 8,000 diverse adult buccal samples. While this clock… Continue reading #CheekAge, a next-generation epigenetic buccal clock, is predictive of mortality in human blood
Risk of #Dementia Diagnosis After Injurious #Falls in Older Adults
Importance Emerging evidence suggests that mild cognitive impairment, which is a precursor to Alzheimer disease and related dementias (ADRD), places older adults at increased risk for falls. However, the risk that an older adult develops dementia after experiencing a fall is unknown.Objective To determine the risk of new ADRD diagnosis after a fall in older… Continue reading Risk of #Dementia Diagnosis After Injurious #Falls in Older Adults
#Metformin decelerates #aging clock in male monkeys
Highlights•Metformin prevents brain atrophy, elevating cognitive function in aged male primates.Metformin slows the pace of aging across diverse male primate tissues•Metformin counterparts neuronal aging, delivering geroprotection via Nrf2 in male primatesSummaryIn a rigorous 40-month study, we evaluated the geroprotective effects of metformin on adult male cynomolgus monkeys, addressing a gap in primate aging research. The… Continue reading #Metformin decelerates #aging clock in male monkeys
#Hormone Therapy and Biological #Aging in Postmenopausal Women
Importance Menopause is associated with biological aging, and hormone therapy (HT) is associated with health outcomes in postmenopausal women.Objective To evaluate the association between HT use and discrepancies between chronological and biological age in postmenopausal women as well as the potential modifying role of socioeconomic status (SES).Design, Setting, and Participants This population-based, retrospective cohort study included postmenopausal women… Continue reading #Hormone Therapy and Biological #Aging in Postmenopausal Women
#Accelerometer-derived ‘weekend warrior’ physical #activity pattern and #brain health
Extensive evidence shows the beneficial effect of adhering to a regular physical activity (PA) pattern on brain health. However, whether the ‘weekend warrior’ pattern, characterized by concentrated moderate-to-vigorous PA (MVPA) over 1–2 days, is associated with brain health is unclear. Here, we perform a prospective cohort study including 75,629 participants from the UK Biobank with validated… Continue reading #Accelerometer-derived ‘weekend warrior’ physical #activity pattern and #brain health
#Ketogenic diet induces p53-dependent cellular #senescence in multiple organs
A ketogenic diet (KD) is a high-fat, low-carbohydrate diet that leads to the generation of ketones. While KDs improve certain health conditions and are popular for weight loss, detrimental effects have also been reported. Here, we show mice on two different KDs and, at different ages, induce cellular senescence in multiple organs, including the heart… Continue reading #Ketogenic diet induces p53-dependent cellular #senescence in multiple organs
Effect of long-term #caloric restriction on telomere length in healthy adults: CALERIE™ 2 trial analysis
Caloric restriction (CR) modifies lifespan and aging biology in animal models. The Comprehensive Assessment of Long-Term Effects of Reducing Intake of Energy (CALERIE™) 2 trial tested translation of these findings to humans. CALERIE™ randomized healthy, nonobese men and premenopausal women (age 21–50y; BMI 22.0–27.9 kg/m2), to 25% CR or ad-libitum (AL) control (2:1) for 2 years. Prior… Continue reading Effect of long-term #caloric restriction on telomere length in healthy adults: CALERIE™ 2 trial analysis
