ObjectiveTo examine the long-term effect of cocoa flavanols on inflammaging biomarkers in the COcoa Supplement and Multivitamin Outcomes Study (COSMOS).MethodsCOSMOS is a large, randomised, double-blind, placebo-controlled, 2 × 2 factorial trial testing the effects of a cocoa extract supplement (containing 500 mg cocoa flavanols/day, including 80 mg (−)-epicatechin) among women aged ≥65 years and men aged ≥60… Continue reading Effects of 2-year #cocoa extract# supplementation on #inflammaging biomarkers in older US adults: findings from the COcoa Supplement and Multivitamin Outcomes Study randomised clinical trial Get access Arrow
Category: Aging
#Meal timing trajectories in #older adults and their associations with #morbidity, genetic profiles, and #mortality
Older adults are vulnerable to mistimed food intake due to health and environmental changes; characterizing meal timing may inform strategies to promote healthy aging. We investigated longitudinal trajectories of self-reported meal timing in older adults and their associations with morbidity, genetic profiles, and all-cause mortality.MethodsWe analyzed data from 2945 community-dwelling older adults from the University… Continue reading #Meal timing trajectories in #older adults and their associations with #morbidity, genetic profiles, and #mortality
The declining #mental #health of the #young and the global disappearance of the #unhappiness hump shape in #age
Across many studies subjective well-being has followed a U-shape in age, declining until people reach middle-age, only to rebound subsequently. Ill-being has followed a mirror-imaged hump-shape. Using graphical and regression analyses of repeat cross-sectional micro-data from the United States and the United Kingdom, we show this empirical regularity has been replaced by a monotonic decrease… Continue reading The declining #mental #health of the #young and the global disappearance of the #unhappiness hump shape in #age
#Dietary patterns and accelerated multimorbidity in #older adults
Diet could influence disease development and shape multimorbidity trajectories. Here we examined how four dietary patterns relate to 15-year multimorbidity accumulation in 2,473 community-dwelling older adults from the Swedish SNAC-K cohort. Multimorbidity was operationalized as the total number of chronic conditions and grouped into three organ systems. Higher adherence to the Mediterranean-DASH Diet Intervention for… Continue reading #Dietary patterns and accelerated multimorbidity in #older adults
Association of #Egg Intake With #Alzheimer’s #Dementia Risk in #Older Adults: The Rush #Memory and Aging Project
BackgroundAlzheimer’s disease (AD) is a neurodegenerative disorder with increasing prevalence due to population aging. Eggs provide many nutrients important for brain health, including choline, omega-3 fatty acids, and lutein. Emerging evidence suggests that frequent egg consumption may improve cognitive performance on verbal tests, but whether consumption influences the risk of Alzheimer’s dementia and AD is… Continue reading Association of #Egg Intake With #Alzheimer’s #Dementia Risk in #Older Adults: The Rush #Memory and Aging Project
DunedinPACNI estimates the longitudinal Pace of #Aging from a single brain #image to track health and disease
To understand how aging affects functional decline and increases disease risk, it is necessary to develop measures of how fast a person is aging. Using data from the Dunedin Study, we introduce an accurate and reliable measure for the rate of longitudinal aging derived from cross-sectional brain magnetic resonance imaging, that is, the Dunedin Pace… Continue reading DunedinPACNI estimates the longitudinal Pace of #Aging from a single brain #image to track health and disease
0350 Objectively-Assessed #Napping Behaviors Predict #Mortality in Middle-to-Older Aged #Adults
IntroductionSelf-reported daytime napping is associated with various adverse health outcomes. We examined whether actigraphy-measured objective daytime napping behaviors predict all-cause mortality in middle-to-older aged adults in the UK Biobank.MethodsWe studied 86,565 participants (baseline age=63 years, SD=8, range: 43-79; 57% female) in the UK Biobank who did not have shiftwork history, completed a 7-day actigraphy monitoring,… Continue reading 0350 Objectively-Assessed #Napping Behaviors Predict #Mortality in Middle-to-Older Aged #Adults
Hybrid hydrogel–extracellular matrix scaffolds identify biochemical and mechanical signatures of #cardiac #ageing
Extracellular matrix remodelling of cardiac tissue is a key contributor to age-related cardiovascular disease and dysfunction. Such remodelling is multifaceted including changes to the biochemical composition, architecture and mechanics, clouding our understanding of how and which extracellular matrix properties contribute to a dysfunctional state. Here we describe a decellularized extracellular matrix–synthetic hydrogel hybrid scaffold that… Continue reading Hybrid hydrogel–extracellular matrix scaffolds identify biochemical and mechanical signatures of #cardiac #ageing
#Rapamycin, Not #Metformin, Mirrors #Dietary Restriction-Driven #Lifespan Extension in Vertebrates: A Meta-Analysis
Dietary restriction (DR) robustly increases lifespan across taxa. However, in humans, long-term DR is difficult to maintain, leading to the search for compounds that regulate metabolism and increase lifespan without reducing caloric intake. The magnitude of lifespan extension from two such compounds, rapamycin and metformin, remains inconclusive, particularly in vertebrates. Here, we conducted a meta-analysis… Continue reading #Rapamycin, Not #Metformin, Mirrors #Dietary Restriction-Driven #Lifespan Extension in Vertebrates: A Meta-Analysis
