BackgroundPrevious studies suggest short-term cognitive benefits of physical activity occurring minutes to hours after exercise. Whether these benefits persist the following day and the role of sleep is unclear. We examined associations of accelerometer-assessed physical activity, sedentary behaviour, and sleep with next-day cognitive performance in older adults.MethodsBritish adults aged 50-83 years (N = 76) without evidence of… Continue reading Associations of accelerometer-measured #physical activity, #sedentary behaviour, and #sleep with next-day #cognitive performance in older adults: a micro-longitudinal study
Author: aledopress
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Screening for advanced #liver fibrosis due to metabolic dysfunction-associated #steatotic liver disease alongside #retina scanning in people with type 2 diabetes: a cross-sectional study
BackgroundInternational guidelines suggest screening for advanced fibrosis due to metabolic dysfunction-associated steatotic liver disease in people with type 2 diabetes, but how to implement these guidelines in clinical care remains unclear. We hypothesise that examination with VCTE could be implemented simultaneously with retina scanning with a high acceptance rate in people with type 2 diabetes.… Continue reading Screening for advanced #liver fibrosis due to metabolic dysfunction-associated #steatotic liver disease alongside #retina scanning in people with type 2 diabetes: a cross-sectional study
#Empagliflozin and the Risk of #Retinopathy in Patients With Type 2 Diabetes
Question Is there an association between empagliflozin and the risk of nonproliferative diabetic retinopathy (NPDR) and diabetic retinopathy (DR) progression in patients with type 2 diabetes (T2D)?Findings In this cohort study, there was no association between empagliflozin and incident NPDR in patients with T2D who had no DR history; however, empagliflozin was associated with a… Continue reading #Empagliflozin and the Risk of #Retinopathy in Patients With Type 2 Diabetes
Biomarker-Guided Antibiotic Duration for Hospitalized Patients With Suspected #SepsisThe ADAPT-Sepsis Randomized Clinical Trial
Question Do critically ill adult patients hospitalized for suspected sepsis and treated with intravenous antibiotics based on procalcitonin (PCT) or C-reactive protein (CRP) protocols, have a safe reduction in treatment duration compared with standard care?Findings In this multicenter, randomized trial of 2760 patients, the daily PCT-guided protocol reduced total antibiotic duration and had noninferior all-cause… Continue reading Biomarker-Guided Antibiotic Duration for Hospitalized Patients With Suspected #SepsisThe ADAPT-Sepsis Randomized Clinical Trial
Device-measured vigorous intermittent lifestyle #physical activity (VILPA) and major adverse cardiovascular events: evidence of sex differences
Background Vigorous intermittent lifestyle physical activity (VILPA) refers to brief bouts of intense physical activity embedded into daily life.Objective To examine sex differences in the dose–response association of VILPA with major adverse cardiovascular events (MACE) and its subtypes.Methods Using multivariable-adjusted cubic splines, we examined the associations of daily VILPA duration with overall MACE and its… Continue reading Device-measured vigorous intermittent lifestyle #physical activity (VILPA) and major adverse cardiovascular events: evidence of sex differences
Added #sugar intake and its associations with incidence of seven different #cardiovascular diseases in 69,705 Swedish men and women
Introduction: The adverse health effects of sugar-sweetened beverage intake are well-established, but the implications of overall added sugar intake remain unclear. We investigated the associations between intake of added sugar and various sugar-sweetened foods and beverages and risk of 7 cardiovascular diseases in 69,705 participants aged 45–83 years (47.2% female) from the Swedish Mammography cohort… Continue reading Added #sugar intake and its associations with incidence of seven different #cardiovascular diseases in 69,705 Swedish men and women
#Chocolate intake and risk of type 2 #diabetes: prospective cohort studies
Objective To prospectively investigate the associations between dark, milk, and total chocolate consumption and risk of type 2 diabetes (T2D) in three US cohorts.Design Prospective cohort studies.Setting Nurses’ Health Study (NHS; 1986-2018), Nurses’ Health Study II (NHSII; 1991-2021), and Health Professionals Follow-Up Study (HPFS; 1986-2020).Participants At study baseline for total chocolate analyses (1986 for NHS… Continue reading #Chocolate intake and risk of type 2 #diabetes: prospective cohort studies
Identifying Early Predictors of #Cognitive Impairment and Dementia in a Large Nationally Representative U.S. Sample
The authors predicted quantitatively meaningful and statistically significant variation in dementia prevalence among persons approximately age 80 according to individuals' observed characteristics when they were about age 60.An individual's baseline cognitive abilities, health, and functional limitations are the strongest predictors of dementia, whereas parental health, family size, marital history, and demographics are the weakest ones.Having… Continue reading Identifying Early Predictors of #Cognitive Impairment and Dementia in a Large Nationally Representative U.S. Sample
Dietary #fructose enhances #tumour growth indirectly via interorgan lipid transfer
Fructose consumption has increased considerably over the past five decades, largely due to the widespread use of high-fructose corn syrup as a sweetener1. It has been proposed that fructose promotes the growth of some tumours directly by serving as a fuel2,3. Here we show that fructose supplementation enhances tumour growth in animal models of melanoma,… Continue reading Dietary #fructose enhances #tumour growth indirectly via interorgan lipid transfer
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