ABSTRACTComplex interrelationships govern the dynamic interactions between gut microbes, the host, and exogenous drivers of disease outcome. A multi-omics approach to cancer prevention by spinach (SPI) was pursued for the first time in the polyposis in rat colon (Pirc) model. SPI fed for 26 weeks (10% w/w, freeze-dried in the diet) exhibited significant antitumor efficacy… Continue reading Dietary #spinach reshapes the gut #microbiome in an Apc-mutant genetic background: mechanistic insights from integrated multi-omics
Author: aledopress
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Metabolic associated fatty #liver disease is the risk factor for chronic #kidney disease
Background & AimsTo clarify the relationship between metabolic dysfunction-associated fatty liver disease (MAFLD) and chronic kidney disease (CKD). MethodsThe participants were divided into four groups by the presence or absence of fatty liver disease (FLD) and metabolic dysfunction (MD). MAFLD was defined as having both FLD and MD, whereas CKD was defined as estimated glomerular… Continue reading Metabolic associated fatty #liver disease is the risk factor for chronic #kidney disease
#Dysbiosis of the gut microbiome impairs mouse skeletal #muscle adaptation to exercise
Dysbiosis of the gut microbiome caused by continuous antibiotic treatment did not affect running activity.Continuous treatment with antibiotics did not result in systemic inflammation as indicated by serum cytokine levels.Gut microbiome dysbiosis was associated with blunted fiber-type specific hypertrophy in the soleus and plantaris muscles in response to progressive weighted wheel running (PoWeR).Gut microbiome dysbiosis… Continue reading #Dysbiosis of the gut microbiome impairs mouse skeletal #muscle adaptation to exercise
Vitamin #D supplementation reduces the risk of #fall in the vitamin D deficient elderly: an updated systematic review and meta-analysis
Vitamin D supplementation has been widely recommended to prevent falls. However, considerable controversy exists regarding the association of such supplementation and fall risk. Previous meta-analyses yielded inconsistent results because of differences in the baseline of 25-hydroxyvitamin D (25[OH]D) and dose of vitamin D and use of vitamin D or in combination with calcium in different… Continue reading Vitamin #D supplementation reduces the risk of #fall in the vitamin D deficient elderly: an updated systematic review and meta-analysis
Assessment of #Allergic and #Anaphylactic Reactions to mRNA #COVID-19 Vaccines With Confirmatory Testing in a US Regional Health System
Objective To characterize the immunologic mechanisms underlying allergic reactions to these vaccines. Design, Setting, and Participants This case series included 22 patients with suspected allergic reactions to mRNA COVID-19 vaccines between December 18, 2020, and January 27, 2021, at a large regional health care network. Participants were individuals who received at least 1 of the… Continue reading Assessment of #Allergic and #Anaphylactic Reactions to mRNA #COVID-19 Vaccines With Confirmatory Testing in a US Regional Health System
Synthesis of human #amyloid restricted to #liver results in an #Alzheimer disease–like neurodegenerative phenotype
Several lines of study suggest that peripheral metabolism of amyloid beta (Aß) is associated with risk for Alzheimer disease (AD). In blood, greater than 90% of Aß is complexed as an apolipoprotein, raising the possibility of a lipoprotein-mediated axis for AD risk. In this study, we report that genetic modification of C57BL/6J mice engineered to… Continue reading Synthesis of human #amyloid restricted to #liver results in an #Alzheimer disease–like neurodegenerative phenotype
Cross-sectional associations of schoolchildren’s #fruit and #vegetable consumption, and meal choices, with their mental well-being: a cross-sectional study
Poor mental well-being is a major issue for young people and is likely to have long-term negative consequences. The contribution of nutrition is underexplored. We, therefore, investigated the association between dietary choices and mental well-being among schoolchildren. Methods Data from 7570 secondary school and 1253 primary school children in the Norfolk Children and Young People… Continue reading Cross-sectional associations of schoolchildren’s #fruit and #vegetable consumption, and meal choices, with their mental well-being: a cross-sectional study
Effects of #Lifestyle Modification on Patients With Resistant #Hypertension: Results of the TRIUMPH Randomized Clinical Trial
#Aging and comorbidities influence the risk of hospitalization and mortality in #diabetic patients experiencing severe hypoglycemia
Severe hypoglycemia requiring access to the Emergency Department is more frequent in older patients with multiple comorbidities.•Risk of hospitalization and mortality within one year since the hypoglycemic event is higher in older frail patients.•Severe hypoglycemia could increase the cardiovascular risk and could be a marker of future cardiovascular events.•A less stringent glycemic control and the… Continue reading #Aging and comorbidities influence the risk of hospitalization and mortality in #diabetic patients experiencing severe hypoglycemia
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