Aims/background: Sepsis is a leading cause of morbidity and mortality in intensive care units (ICUs). Early identification of patients at high risk of death is essential to guide timely interventions and optimize resource allocation. This study aimed to develop and validate an interpretable machine learning model for predicting 28-day mortality in adult ICU patients.Methods: We… Continue reading Development and Validation of an Interpretable Machine Learning-Based Prediction Model of Sepsis: A Retrospective Multicenter Cohort Study
Category: Infectivology
Comparative Diagnostic Performance of Oral Microbial Habitats for Periodontitis
Periodontitis affects more than 1 billion people worldwide but remains largely underdiagnosed. The oral microbiota offers a noninvasive diagnostic window, but studies based on 16S rRNA data have reported heterogeneous and often suboptimal performance. It remains unclear which oral habitat and modeling strategy best support clinical decision making. We analyzed 2,303 adult samples from 33… Continue reading Comparative Diagnostic Performance of Oral Microbial Habitats for Periodontitis
Long-term impact of acute pancreatitis on patients’ quality of life: a multi-center prospective study in Japan
Background: Although acute pancreatitis often resolves, its long-term impact on health-related quality of life (HRQoL) and social participation remains unclear. This study investigated the longitudinal changes in HRQoL and factors affecting incomplete recovery of social participation following acute pancreatitis.Methods: This multi-center, prospective cohort study included patients aged ≥ 18 years who were hospitalized with acute… Continue reading Long-term impact of acute pancreatitis on patients’ quality of life: a multi-center prospective study in Japan
Association between clinical frailty and multidrug-resistant positive cultures in hospitalized older adults
Frailty is a key determinant of adverse outcomes in older adults. The association between clinical frailty and multidrug-resistant (MDR) positive cultures in hospitalized older adults remains insufficiently defined. Understanding this association may improve early risk stratification and inform infection control strategies in acute care. We conducted a prospective, observational, single-center cohort study in an internal… Continue reading Association between clinical frailty and multidrug-resistant positive cultures in hospitalized older adults
Post-Marketing Safety Signals of Microbiota-Based Live Biotherapeutic Products for Recurrent Clostridioides difficile Infection: A FAERS Pharmacovigilance Study
Background: REBYOTA and VOWST are the first FDA-approved live biotherapeutic products (LBPs) for recurrent Clostridioides difficile infection (rCDI). Prior FDA safety alerts (2019-2020) regarding invasive infections from investigational fecal microbiota transplantation underscore the need for post-marketing surveillance of these novel products.Aims: To characterize the real-world safety profiles of REBYOTA and VOWST using the FDA Adverse… Continue reading Post-Marketing Safety Signals of Microbiota-Based Live Biotherapeutic Products for Recurrent Clostridioides difficile Infection: A FAERS Pharmacovigilance Study
Management of Infected Wounds: A Wound Healing Foundation Consensus Statement
The Wound Healing Foundation (WHF) previously organized consensus panels on the management of chronic #wounds (2022), acute wounds (2024), and diabetic wounds (2025). This WHF consensus statement, authored by a global interdisciplinary panel of clinicians and researchers, focuses on the management of infected wounds. The panel members reviewed the literature and reached consensus on elements… Continue reading Management of Infected Wounds: A Wound Healing Foundation Consensus Statement
Machine Learning-Based Prediction Model for Infectious Complications in Trauma and Its Association With In-Hospital Mortality
Background: Infectious complications, such as #sepsis or catheter-related infections, are common and serious sequelae after trauma. Despite their clinical significance, existing risk-prediction models are limited by reliance on in-hospital data that fail to capture complex physiological interactions. Thus, this study aimed to develop and validate an interpretable ensemble machine learning (ML) model integrating both prehospital… Continue reading Machine Learning-Based Prediction Model for Infectious Complications in Trauma and Its Association With In-Hospital Mortality
Reevaluation of surgical strategies for chronic periprosthetic joint infection: a comparison of short-term outcomes between one-stage and two-stage revision
Objective: This study aims to compare the short-term clinical outcomes of one-stage and two-stage revision surgeries for treating chronic periprosthetic joint infection (#PJI ), addressing the limitations of the prolonged treatment cycle and heavy medical burden associated with two-stage revision, and evaluating the feasibility and effectiveness of one-stage revision as an alternative therapeutic strategy.Methods: This… Continue reading Reevaluation of surgical strategies for chronic periprosthetic joint infection: a comparison of short-term outcomes between one-stage and two-stage revision
Antibiotic Exposure Patterns and Clinical Outcomes Preceding Clostridioides difficile Infection: A Retrospective Observational Study
Background #Clostridioides difficile infection (CDI) remains a major cause of healthcare-associated morbidity and mortality, with antibiotic exposure recognized as the principal modifiable risk factor. Variability in antibiotic class, duration, and overlap may influence CDI risk and clinical severity. Local audits of prescribing patterns are essential to inform antimicrobial stewardship strategies. Objective The objective of the… Continue reading Antibiotic Exposure Patterns and Clinical Outcomes Preceding Clostridioides difficile Infection: A Retrospective Observational Study
