Atrial fibrillation and heart failure with reduced ejection fraction (HFrEF) are common sources of cardioembolism. While oral anticoagulation is strongly recommended for atrial fibrillation, there are marked variations in guideline recommendations for HFrEF due to uncertainty about net clinical benefit. This systematic review and meta-analysis evaluates the comparative association of oral anticoagulation with stroke and… Continue reading Association of Oral #Anticoagulation With #Stroke in Atrial #Fibrillation or Heart #Failure: A Comparative Meta-Analysis
Tag: stroke
The #CHA2DS2-VASc Score for Risk Stratification of #Stroke in Heart Failure With-vs-Without Atrial #Fibrillation
A recent study suggested that the CHA2DS2-VASc score can risk stratify heart failure (HF) patients without atrial fibrillation (AF) for stroke. We performed a retrospective analysis using the national Veteran Affairs database to externally validate the findings. Crude incidence rates of end points were calculated. A Cox proportional model was used to study the association… Continue reading The #CHA2DS2-VASc Score for Risk Stratification of #Stroke in Heart Failure With-vs-Without Atrial #Fibrillation
#Gut microbes impact #stroke severity via the trimethylamine N-oxide pathway
Clinical studies have demonstrated associations between circulating levels of the gut-microbiota-derived metabolite trimethylamine-N-oxide (TMAO) and stroke incident risk. However, a causal role of gut microbes in stroke has not yet been demonstrated. Herein we show that gut microbes, through dietary choline and TMAO generation, directly impact cerebral infarct size and adverse outcomes following stroke. Fecal… Continue reading #Gut microbes impact #stroke severity via the trimethylamine N-oxide pathway
Serial #sarcomere number is substantially decreased within the paretic #biceps brachii in individuals with chronic hemiparetic #stroke
A muscle’s structure, or architecture, is indicative of its function and is plastic; changes in input to or use of the muscle alter its architecture. Stroke-induced neural deficits substantially alter both input to and usage of individual muscles. We combined in vivo imaging methods (second-harmonic generation microendoscopy, extended field-of-view ultrasound, and fat-suppression MRI) to quantify… Continue reading Serial #sarcomere number is substantially decreased within the paretic #biceps brachii in individuals with chronic hemiparetic #stroke
The risk of ischemic #stroke and hemorrhagic stroke in Chinese adults with low-density lipoprotein #cholesterol concentrations < 70 mg/dL
The risk of stroke in individuals with very low low-density lipoprotein cholesterol (LDL-C) concentrations remains high. We sought to prioritize predictive risk factors for stroke in Chinese participants with LDL-C concentrations < 70 mg/dL using a survival conditional inference tree, a machine learning method. MethodsThe training dataset included 9327 individuals with LDL-C concentrations < 70 mg/dL who were free… Continue reading The risk of ischemic #stroke and hemorrhagic stroke in Chinese adults with low-density lipoprotein #cholesterol concentrations < 70 mg/dL
#Thyroid Hormone Therapy and Incident #Stroke
Stroke is a leading cause of death and disability and there is a need to identify modifiable risk factors. ObjectiveDetermine the relationship between thyroid hormone treatment intensity and incidence of atrial fibrillation and stroke. DesignRetrospective cohort study using data from the Veterans Health Administration between 2004 and 2017, with a median follow-up of 59 months.… Continue reading #Thyroid Hormone Therapy and Incident #Stroke
Effect of #bariatric surgery on ischemic #stroke risk
Bariatric surgery has demonstrated improvements in cardiovascular health. The effect on ischemic stroke risk remains unclear. The goal of this study was to compare the risk of stroke among bariatric surgery patients versus controls. MethodsUsing Mariner, a national all-payer claims database, we identified patients with BMI > 40, or BMI > 35 with qualifying comorbidities… Continue reading Effect of #bariatric surgery on ischemic #stroke risk
Increased #Risk of Stroke in Patients With #Obsessive-Compulsive Disorder: A Nationwide Longitudinal Study
Patients with obsessive-compulsive disorder (OCD) tend to be comorbid with stroke-related risk factors, including obesity, hypertension, and diabetes. However, the temporal association between OCD and subsequent stroke risk is unclear. Methods:Using data collected between 2001 and 2010 by Taiwan’s National Health Insurance Research Database, 28 064 adult patients with OCD (International Classification of Diseases, Ninth… Continue reading Increased #Risk of Stroke in Patients With #Obsessive-Compulsive Disorder: A Nationwide Longitudinal Study
The Effects of Aerobic #Exercise on Serum Biomarkers of Neuroplasticity and Brain Repair in #Stroke: A Systematic Review
To provide a novel overview of the literature and to summarise the evidence for the effects of aerobic exercise (AE) on serum biomarkers neuroplasticity and brain repair in stroke survivors. Data SourceWe conducted a systematic review and searched MEDLINE, EMBASE and Cochrane CENTRAL using terms related to AE, neuroplasticity, brain repair, and stroke. Study SelectionTitles,… Continue reading The Effects of Aerobic #Exercise on Serum Biomarkers of Neuroplasticity and Brain Repair in #Stroke: A Systematic Review
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