Association Between Electronic Diary–Rated #Sleep, Mood, Energy, and #Stress With Incident #Headache in a Community-Based Sample

The aim of this study was to examine the diurnal links between average and changes in average levels of prospectively rated mood, sleep, energy, and stress as predictors of incident headache in a community-based sample.MethodsThis observational study included structured clinical diagnostic assessment of both headache syndromes and mental disorders and electronic diaries that were administered… Continue reading Association Between Electronic Diary–Rated #Sleep, Mood, Energy, and #Stress With Incident #Headache in a Community-Based Sample

The psychophysiology of Mastermind: Characterizing response times and #blinking in a high-stakes television game show

Television game shows have proven to be a valuable resource for studying human behavior under conditions of high and high stakes. However, previous work has focused mostly on choices—ignoring much of the rich visual information that is available on screen. Here, we take a first step to extracting more of this information by investigating… Continue reading The psychophysiology of Mastermind: Characterizing response times and #blinking in a high-stakes television game show

Psychosocial #Stressors at #Work and #Coronary Heart Disease Risk in Men and Women: 18-Year Prospective Cohort Study of Combined Exposures

Psychosocial stressors at work, like job strain and effort-reward imbalance (ERI), can increase coronary heart disease (CHD) risk. ERI indicates an imbalance between the effort and received rewards. Evidence about the adverse effect of combined exposure to these work stressors on CHD risk is scarce. This study examines the separate and combined effect of job… Continue reading Psychosocial #Stressors at #Work and #Coronary Heart Disease Risk in Men and Women: 18-Year Prospective Cohort Study of Combined Exposures

Stress test abnormalities reveal more than just cardiovascular risks, Mayo Clinic study finds

The treadmill exercise test with electrocardiogram (ECG), also known as an exercise stress test, is one of the most familiar tests in medicine. While exercise testing typically is focused on diagnosing coronary artery disease, a recent study from Mayo Clinic finds that exercise test abnormalities, such as low functional aerobic capacity, predicted non-cardiovascular causes of death such as… Continue reading Stress test abnormalities reveal more than just cardiovascular risks, Mayo Clinic study finds

Differential network interactions between #psychosocial factors, #mental health, and health-related quality of life in women and men

Psychosocial factors affect mental health and health-related quality of life (HRQL) in a complex manner, yet gender differences in these interactions remain poorly understood. We investigated whether psychosocial factors such as social support and personal and work-related concerns impact mental health and HRQL differentially in women and men during the first year of the COVID-19… Continue reading Differential network interactions between #psychosocial factors, #mental health, and health-related quality of life in women and men

Burnout, Professionalism, and the Quality of US Health Care

Physician burnout is a major threat to health care quality, patient outcomes, and the vitality of the medical workforce.1 More than half of US physicians report at least 1 symptom of burnout—nearly twice the rate of the general working population—and many also experience depression, anxiety, or suicidal ideation.2 Burnout is estimated to cost the health… Continue reading Burnout, Professionalism, and the Quality of US Health Care

Repeated psychological stress, chronic vicarious social defeat stress, evokes irritable bowel syndrome-like symptoms in mice

Increasing evidence has demonstrated that emotional states and intestinal conditions are inter-connected in so-called “brain–gut interactions.” Indeed, many psychiatric disorders are accompanied by gastrointestinal symptoms, such as the irritable bowel syndrome (IBS). However, the functional connection remains elusive, partly because there are few useful experimental animal models. Here, we focused on a highly validated animal… Continue reading Repeated psychological stress, chronic vicarious social defeat stress, evokes irritable bowel syndrome-like symptoms in mice

How nature nurtures: Amygdala activity decreases as the result of a one-hour walk in nature

Since living in cities is associated with an increased risk for mental disorders such as anxiety disorders, depression, and schizophrenia, it is essential to understand how exposure to urban and natural environments affects mental health and the brain. It has been shown that the amygdala is more activated during a stress task in urban compared… Continue reading How nature nurtures: Amygdala activity decreases as the result of a one-hour walk in nature

Stress-induced protein disaggregation in the endoplasmic reticulum catalysed by BiP

Protein synthesis is supported by cellular machineries that ensure polypeptides fold to their native conformation, whilst eliminating misfolded, aggregation prone species. Protein aggregation underlies pathologies including neurodegeneration. Aggregates’ formation is antagonised by molecular chaperones, with cytoplasmic machinery resolving insoluble protein aggregates. However, it is unknown whether an analogous disaggregation system exists in the Endoplasmic Reticulum… Continue reading Stress-induced protein disaggregation in the endoplasmic reticulum catalysed by BiP