The burgeoning field of the microbiome–gut–brain axis has inspired research into how the gut microbiome can affect human emotion. Probiotics offer ways to investigate microbial-based interventions but results have been mixed, with more evidence of beneficial effects in clinically depressed patients. Using a randomised, double-blind, placebo-controlled design in 88 healthy volunteers, we conduct a comprehensive… Continue reading #Probiotics reduce negative #mood over time: the value of daily self-reports in detecting effects
Tag: probiotics
#Probiotics and #Fever Duration in Children With Upper Respiratory Tract Infections
Importance Upper respiratory tract infections (URTIs) are prevalent in children, prompting frequent health care consultations, especially among those with fever. Probiotics show potential as an adjuvant treatment for URTIs, but evidence in children is limited.Objective To evaluate the efficacy of a probiotic mixture containing Bifidobacterium breve M-16V, Bifidobacterium lactis HN019, and Lactobacillus rhamnosus HN001 in… Continue reading #Probiotics and #Fever Duration in Children With Upper Respiratory Tract Infections
Efficacy of probiotics in the management of halitosis: a systematic review and meta-analysis
Background Halitosis is defined as a foul odour emitted from the oral cavity. Many interventions have been used to control halitosis from mouthwashes to chewing gums. Probiotics have been reported as an alternative method to alleviate halitosis.Objective The present study aimed to investigate the effect of probiotics on halitosis from a time perspective.Design and methods This is a… Continue reading Efficacy of probiotics in the management of halitosis: a systematic review and meta-analysis
Probiotics for Mild Cognitive Impairment and Alzheimer’s Disease: A Systematic Review and Meta-Analysis
Accumulating evidence from animal studies supports the potential role of probiotics and prebiotics in alleviating neurodegenerative diseases. However, whether dietary supplementation with probiotics improves cognitive function in patients with Alzheimer’s disease (AD) or mild cognitive impairment (MCI) is unclear. We searched literature databases for relevant randomized control trials and compared the outcomes between control/placebo and… Continue reading Probiotics for Mild Cognitive Impairment and Alzheimer’s Disease: A Systematic Review and Meta-Analysis
Self-tunable engineered yeast #probiotics for the treatment of #inflammatory bowel disease
Inflammatory bowel disease (IBD) is a complex chronic inflammatory disorder of the gastrointestinal tract. Extracellular adenosine triphosphate (eATP) produced by the commensal microbiota and host cells activates purinergic signaling, promoting intestinal inflammation and pathology. Based on the role of eATP in intestinal inflammation, we developed yeast-based engineered probiotics that express a human P2Y2 purinergic receptor… Continue reading Self-tunable engineered yeast #probiotics for the treatment of #inflammatory bowel disease
Effects of #probiotics on gut #microbiota: mechanisms of intestinal immunomodulation and neuromodulation
Recent explorations of the human gut microbiota suggest that perturbations of microbial communities may increase predisposition to different disease phenotypes. Dietary nutrients may be converted into metabolites by intestinal microbes that serve as biologically active molecules affecting regulatory functions in the host. Probiotics may restore the composition of the gut microbiome and introduce beneficial functions… Continue reading Effects of #probiotics on gut #microbiota: mechanisms of intestinal immunomodulation and neuromodulation
#Probiotic Properties of #Escherichia coli Nissle in Human Intestinal Organoids
Probiotic, or beneficial, bacteria, such as E. coli Nissle, hold promise for the treatment of human disease. More study is needed to fully realize the potential of probiotics. Safety and efficacy studies are critically important; however, mice are poor models for many human intestinal diseases. We used stem cell-derived human intestinal organoid tissues to evaluate… Continue reading #Probiotic Properties of #Escherichia coli Nissle in Human Intestinal Organoids
Food & mood: a review of supplementary prebiotic and probiotic interventions in the treatment of anxiety and depression in adult
A bidirectional relationship exists between the brain and the gastrointestinal tract. Foods containing bacteria that positively influence the gastrointestinal microbiome are termed, probiotics; compounds that promote the flourishing of these bacteria are termed, prebiotics. Whether microbiome influencing therapies could treat psychiatric conditions, including depression and anxiety, is an area of interest. Presently, no established consensus… Continue reading Food & mood: a review of supplementary prebiotic and probiotic interventions in the treatment of anxiety and depression in adult
Probiotic Bacillus subtilis Protects against α-Synuclein Aggregation in C. elegans
Recent discoveries have implicated the gut #microbiome in the progression and severity of #Parkinson’s disease; however, how gut bacteria affect such neurodegenerative disorders remains unclear. Here, we report that the Bacillus subtilis probiotic strain PXN21 inhibits α-synuclein aggregation and clears preformed aggregates in an established Caenorhabditis elegans model of synucleinopathy. This protection is seen in… Continue reading Probiotic Bacillus subtilis Protects against α-Synuclein Aggregation in C. elegans
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