Aim: In this cohort, we aimed to study the evolution of pregenomic RNA (pgRNA) during treatment and compare it with other disease scores such as FIB-4 and PAGE-B.Methods: Eighty-eight HBeAg negative CHB who received long-term treatment with NAs were included. A quantitative HBV S antigen (HBsAg) assay was performed, and viral HBV DNA was quantified… Continue reading Is there any role for #HBV pgRNA in #fibrosis and #HCC predisposition?
Tag: liver-fibrosis
#Tetrachloroethylene Is Associated With Presence of Significant Liver #Fibrosis: A National Cross-Sectional Study in US Adults
Background & AimsTetrachloroethylene (PCE) is a volatile organic compound (VOC) used in industrial settings. Pre-clinical studies have linked PCE to hepatotoxicity, but clinical data beyond selected occupational cohorts represent a critical knowledge gap.MethodsWe utilised data from the National Health and Nutrition Examination Survey (NHANES) from 2017 to 2020, a nationally representative survey of the US… Continue reading #Tetrachloroethylene Is Associated With Presence of Significant Liver #Fibrosis: A National Cross-Sectional Study in US Adults
#Coffee for the #liver: a mechanistic approach
The liver, which is essential for metabolism and detoxification, is vulnerable to various damaging factors, including viral infections, excessive alcohol consumption, and a diet high in fat and sugar. Coffee, one of the most widely consumed beverages worldwide, is valued not only for its flavor and aroma but also for its potential health benefits. In… Continue reading #Coffee for the #liver: a mechanistic approach
Screening for advanced #liver fibrosis due to metabolic dysfunction-associated #steatotic liver disease alongside #retina scanning in people with type 2 diabetes: a cross-sectional study
BackgroundInternational guidelines suggest screening for advanced fibrosis due to metabolic dysfunction-associated steatotic liver disease in people with type 2 diabetes, but how to implement these guidelines in clinical care remains unclear. We hypothesise that examination with VCTE could be implemented simultaneously with retina scanning with a high acceptance rate in people with type 2 diabetes.… Continue reading Screening for advanced #liver fibrosis due to metabolic dysfunction-associated #steatotic liver disease alongside #retina scanning in people with type 2 diabetes: a cross-sectional study
Elevated C-reactive protein mediates the liver-brain axis: a preliminary study
BackgroundChronic liver diseases of all etiologies exist along a spectrum with varying degrees of hepatic fibrosis. Despite accumulating evidence implying associations between liver fibrosis and cognitive functioning, there is limited research exploring the underlying neurobiological factors and the possible mediating role of inflammation on the liver-brain axis.MethodsUsing data from the UK Biobank, we examined the cross-sectional association… Continue reading Elevated C-reactive protein mediates the liver-brain axis: a preliminary study
Mortality Outcomes by Fibrosis Stage in Nonalcoholic Fatty Liver Disease: A Systematic Review and Meta-analysis
Fibrosis is a key determinant of clinical outcomes in nonalcoholic fatty liver disease (NAFLD), but time-dependent risk of mortality has not been reported in previous meta-analyses. We performed an updated time-to-event meta-analysis to provide robust estimates for all-cause and liver-related mortality in biopsy-confirmed NAFLD with comparisons between fibrosis stages.MethodsMedline and Embase databases were searched to… Continue reading Mortality Outcomes by Fibrosis Stage in Nonalcoholic Fatty Liver Disease: A Systematic Review and Meta-analysis
Effect of liver steatosis on liver stiffness measurement in chronic hepatitis B patients with normal serum alanine aminotransferase levels: A multicentre cohort study
Liver steatosis is becoming increasingly common in patients with chronic hepatitis B (CHB), and its effect on liver stiffness measurement (LSM), as assessed by transient elastography, remains controversial. Seven hundred and fifty-five patients with CHB and normal serum alanine aminotransferase levels, who underwent vibration-controlled transient elastography and liver biopsy, were included in the study. We… Continue reading Effect of liver steatosis on liver stiffness measurement in chronic hepatitis B patients with normal serum alanine aminotransferase levels: A multicentre cohort study
Food Insecurity is Associated with Mortality Among U.S. Adults with Nonalcoholic Fatty Liver Disease and Advanced Fibrosis
Food insecurity is a growing public health challenge in the U.S. and has been linked to nonalcoholic fatty liver disease (NAFLD) and advanced fibrosis. However, little is known of how food insecurity impacts mortality risk and healthcare utilization (HCU) in chronic liver disease. MethodsUsing a population-based cohort study of U.S. adults (≥20 years) in the… Continue reading Food Insecurity is Associated with Mortality Among U.S. Adults with Nonalcoholic Fatty Liver Disease and Advanced Fibrosis
Liver expression of IL-22, IL-22R1 and IL-22BP in patients with chronic hepatitis C with different fibrosis stages
Highlights•Liver biopsies at stage F1 to F3 expressed more IL-22 than F0 or F4. •The number of cells expressing IL-22R1 decreased as fibrosis increased. •There was an increase in Il-22BP staining in more advanced stages of fibrosis. •IL-22 pathway may be involved in the pathophysiology of liver fibrosis. AbstractLiver fibrosis is the result of an… Continue reading Liver expression of IL-22, IL-22R1 and IL-22BP in patients with chronic hepatitis C with different fibrosis stages
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