Molecular routes to metastatic dissemination are critical determinants of aggressive cancers. Through in vivo CRISPR–Cas9 genome editing, we generated somatic mosaic genetically engineered models that faithfully recapitulate metastatic renal tumors. Disruption of 9p21 locus is an evolutionary driver to systemic disease through the rapid acquisition of complex karyotypes in cancer cells. Cross-species analysis revealed that… Continue reading Interferon signaling promotes tolerance to chromosomal instability during metastatic evolution in renal cancer
Tag: Kidney
Visit-to-visit variability in albuminuria predicts renal function deterioration in patients with type 2 diabetes
Aims/IntroductionWe aimed to study the predictive ability of visit-to-visit variability in albuminuria for changes in renal function in patients with type 2 diabetes mellitus. Materials and MethodsThe cohort study was carried out in a single medical center. In the model development cohort of 1008 subjects, we developed the albuminuria variability score (AVS) to evaluate the visit-to-visit… Continue reading Visit-to-visit variability in albuminuria predicts renal function deterioration in patients with type 2 diabetes
Comprehensive investigations revealed consistent pathophysiological alterations after vaccination with COVID-19 vaccines
Large-scale COVID-19 vaccinations are currently underway in many countries in response to the COVID-19 pandemic. Here, we report, besides generation of neutralizing antibodies, consistent alterations in hemoglobin A1c, serum sodium and potassium levels, coagulation profiles, and renal functions in healthy volunteers after vaccination with an inactivated SARS-CoV-2 vaccine. Similar changes had also been reported in… Continue reading Comprehensive investigations revealed consistent pathophysiological alterations after vaccination with COVID-19 vaccines
Diffusion-Magnetic Resonance Imaging predicts decline of kidney function in chronic kidney disease and in patients with a kidney allograft
Kidney cortical interstitial fibrosis is highly predictive of kidney prognosis and is currently assessed by evaluation of a biopsy. Diffusion-weighted magnetic resonance imaging is a promising non-invasive tool to evaluate kidney fibrosis. We recently adapted diffusion-weighted imaging sequence for discrimination between the kidney cortex and medulla and found that the cortico-medullary difference in apparent diffusion… Continue reading Diffusion-Magnetic Resonance Imaging predicts decline of kidney function in chronic kidney disease and in patients with a kidney allograft
Effect of Low-Dose Methotrexate on eGFR and Kidney Adverse Events: A Randomized Clinical Trial
Low-dose methotrexate (LD-MTX) is contraindicated in advanced CKD, but kidney safety in normal kidney function or mild-to-moderate CKD is less clear. Methods We performed a secondary analysis for eGFR and kidney AEs using the randomized double-blind, placebo-controlled Cardiovascular Inflammation Reduction Trial. Adults with cardiovascular disease and diabetes and/or metabolic syndrome were randomly allocated to oral… Continue reading Effect of Low-Dose Methotrexate on eGFR and Kidney Adverse Events: A Randomized Clinical Trial
#Metabolic Syndrome, and Not #Obesity, Is Associated with Chronic #Kidney Disease
Obese (OB) patients are at increased risk of chronic kidney disease, but it is still unclear whether this can be attributed to obesity per se or to the associated metabolic derangements. The aim of this study was to evaluate the relative impact of obesity and metabolic syndrome (MS) on kidney disease. Methods: This is a… Continue reading #Metabolic Syndrome, and Not #Obesity, Is Associated with Chronic #Kidney Disease
Meta-Analysis of the Relationship between Abdominal #Obesity and Diabetic #Kidney Disease in Type 2 #Diabetic Patients
The meta-analysis aimed to investigate the association of visceral fat area (VFA), waist circumference (WC), waist-hip ratio (WHR) and waist-height ratio (WHtR) with diabetic kidney disease (DKD) in type 2 diabetic patients. Methods: Included studies were searched from Pubmed, Embase, and the Cochrane Library before July 2020. We synthesized the pooled results of the above… Continue reading Meta-Analysis of the Relationship between Abdominal #Obesity and Diabetic #Kidney Disease in Type 2 #Diabetic Patients
Association of #Depressive Symptoms with Rapid #Kidney Function Decline in Adults with Normal Kidney Function
The relationship of depressive symptoms with kidney function remains poorly investigated. We aimed to evaluate the prospective association between depressive symptoms and rapid decline in kidney function in Chinese adults with normal kidney function. Design, setting, participants, & measurements A total of 4763 participants with eGFR≥60 ml/min per 1.73 m2 at baseline were enrolled from… Continue reading Association of #Depressive Symptoms with Rapid #Kidney Function Decline in Adults with Normal Kidney Function
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