Importance With the high burden of hypertension in sub-Saharan Africa, there is a need for effective, safe and scalable treatment strategies.Objective To compare, among Black African adults, the effectiveness and safety of a novel low-dose triple-pill protocol compared with a standard-care protocol for blood pressure lowering.Design and Setting Randomized, parallel-group, open-label, multicenter trial conducted in public hospital–based family medicine… Continue reading Low-Dose Triple-Pill vs Standard-Care Protocols for #Hypertension Treatment in NigeriaA Randomized Clinical Trial
Tag: Hypertension
Effect of timed dosing of usual #antihypertensives according to patient chronotype on #cardiovascular outcomes: the Chronotype sub-study cohort of the Treatment in Morning versus Evening (TIME) study
BackgroundTiming drug administration to endogenous circadian rhythms may enhance treatment efficacy. In the Chronotype sub-study of the Treatment in Morning versus Evening (TIME) clinical trial we examined whether timing of usual antihypertensive medications according to patient chronotype (a behavioural marker of personal circadian rhythm) may influence clinical cardiovascular outcomes.MethodsThis was a cohort sub-study of TIME,… Continue reading Effect of timed dosing of usual #antihypertensives according to patient chronotype on #cardiovascular outcomes: the Chronotype sub-study cohort of the Treatment in Morning versus Evening (TIME) study
Effect of #Tai Chi vs Aerobic #Exercise on Blood #Pressure in Patients With PrehypertensionA Randomized Clinical Trial
Importance Prehypertension increases the risk of developing hypertension and other cardiovascular diseases. Early and effective intervention for patients with prehypertension is highly important.Objective To assess the efficacy of Tai Chi vs aerobic exercise in patients with prehypertension.Design, Setting, and Participants This prospective, single-blinded randomized clinical trial was conducted between July 25, 2019, and January 24, 2022, at 2… Continue reading Effect of #Tai Chi vs Aerobic #Exercise on Blood #Pressure in Patients With PrehypertensionA Randomized Clinical Trial
Association between #tomato consumption and #blood pressure in an older population at high cardiovascular risk: observational analysis of PREDIMED trial
Clinical studies have produced conflicting evidence on the effects of the consumption of tomatoes on blood pressure, and there are limited data from epidemiologic studies. This study assesses whether tomato consumption (Solanum lycopersicum L.) is associated with systolic and diastolic blood pressure, and the risk of hypertension in a prospective 3-year longitudinal study in older adults… Continue reading Association between #tomato consumption and #blood pressure in an older population at high cardiovascular risk: observational analysis of PREDIMED trial
Effect of Dietary #Sodium on Blood #PressureA Crossover Trial
Dietary sodium recommendations are debated partly due to variable blood pressure (BP) response to sodium intake. Furthermore, the BP effect of dietary sodium among individuals taking antihypertensive medications is understudied.Objectives To examine the distribution of within-individual BP response to dietary sodium, the difference in BP between individuals allocated to consume a high- or low-sodium diet first,… Continue reading Effect of Dietary #Sodium on Blood #PressureA Crossover Trial
#Sleeping Difficulties, #Sleep Duration, and Risk of #Hypertension in Women
Rates of poor sleep and hypertension are alarming worldwide. In this study, we investigate the association between sleeping difficulties and sleep duration with hypertension risk in women.METHODS:Sixty-six thousand one hundred twenty-two participants of the NHS2 (Nurses’ Health Study 2), who were free of hypertension at baseline (2001), were followed prospectively for 16 years and incident… Continue reading #Sleeping Difficulties, #Sleep Duration, and Risk of #Hypertension in Women
Seated And Supine Blood #Pressure And Risk Of #Cardiovascular Disease And Mortality From The Atherosclerosis Risk In Communities Study
Background Hypertension (HTN) while asleep is strongly associated with cardiovascular disease (CVD) and death. Whether HTN while supine in clinic is a risk factor for CVD independent of seated BP remains unknown.Objectives To determine the relationship between supine HTN and adverse CVD.Methods The Atherosclerosis Risk in Communities (ARIC) Study measured supine and seated BP during visit 1 (1987-1989).… Continue reading Seated And Supine Blood #Pressure And Risk Of #Cardiovascular Disease And Mortality From The Atherosclerosis Risk In Communities Study
Recovery #sleep following sleep restriction is insufficient to return elevated daytime heart #rate and systolic blood #pressure to baseline levels
Objective Sleep restriction alters daytime cardiac activity, including elevating heart rate (HR) and blood pressure (BP). There is minimal research on the cumulative effects of sleep loss and the response after subsequent recovery sleep on HR and BP. This study examined patterns of HR and BP across baseline, sleep restriction, and recovery conditions using multiple daytime cardiac… Continue reading Recovery #sleep following sleep restriction is insufficient to return elevated daytime heart #rate and systolic blood #pressure to baseline levels
Infused juice concentrate of Japanese plum Prunus mume attenuates inflammatory vascular remodeling in a mouse model of hypertension induced by angiotensin II
Fruit from the Prunus mume tree is a traditional food in Japan. Recently, bainiku-ekisu, an infused juice concentrate of Japanese Prunus mume, is attracting attention as a health promoting supplement. Angiotensin II (Ang II) plays a central role in development of hypertension. It has been reported that bainiku-ekisu treatment attenuates the growth-promoting signaling induced by Ang II in… Continue reading Infused juice concentrate of Japanese plum Prunus mume attenuates inflammatory vascular remodeling in a mouse model of hypertension induced by angiotensin II
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