Growing evidence suggests that exposure to per- and polyfluoroalkyl substances ( #PFAS ) are linked to an increased risk of type 2 diabetes (T2D); however, the effect of PFAS mixtures and underlying mechanisms are not well understood. We examined the associations between exposure to PFAS mixture with later T2D diagnosis and underlying metabolic dysregulations.MethodsWe conducted… Continue reading Exposure to per- and poly-fluoroalkyl substances in association to later occurrence of type 2 #diabetes and metabolic pathway #dysregulation in a multiethnic US population
Tag: Diabetes
Association of #Weekend #Warrior and Other Physical #Activity Patterns With #Mortality Among Adults With #Diabetes: A Cohort Study
Background:“Weekend warrior” and regularly active physical activity patterns have been associated with reduced mortality risk in the general population. The association in patients with diabetes is unknown.Objective:To examine the associations of different physical activity patterns, particularly weekend warrior and regularly active behavior, with all-cause, cardiovascular, and cancer mortality among adults with diabetes.Design:Prospective cohort study.Setting:National Health… Continue reading Association of #Weekend #Warrior and Other Physical #Activity Patterns With #Mortality Among Adults With #Diabetes: A Cohort Study
Later #eating #timing in relation to an individual internal clock is associated with lower #insulin sensitivity and affected by genetic factors
BackgroundAlthough the contribution of the circadian clock to metabolic regulation is widely recognized, the role of eating timing in glucose metabolism and diabetes risk remains insufficiently studied. This study aimed (i) to investigate the link between the eating timing pattern relative to individual clock and glucose homoeostasis and (ii) to explore the contribution of genetic… Continue reading Later #eating #timing in relation to an individual internal clock is associated with lower #insulin sensitivity and affected by genetic factors
Dietary #Sugar Intake and Incident Type 2 #Diabetes Risk: A Systematic Review and Dose-Response Meta-Analysis of Prospective Cohort Studies
The dose-response relationship between dietary sugar and type 2 diabetes (T2D) risk is uncertain. MEDLINE, Embase, CINAHL, Web of Science and Cochrane databases were searched through July 9, 2024 for prospective cohort studies reporting relative measures of incident T2D risk by categories of dietary sugar (total, free, added, fructose, sucrose) or 2 beverage sources (non-diet… Continue reading Dietary #Sugar Intake and Incident Type 2 #Diabetes Risk: A Systematic Review and Dose-Response Meta-Analysis of Prospective Cohort Studies
GLP-1RA and SGLT2i Medications for Type 2 #Diabetes and #Alzheimer Disease and Related Dementias
Importance The association between glucagon-like peptide-1 receptor agonists (GLP-1RAs) and sodium-glucose cotransporter-2 inhibitors (SGLT2is) and risk of Alzheimer disease and related dementias (ADRD) remains to be confirmed.Objective To assess the risk of ADRD associated with GLP-1RAs and SGLT2is in people with type 2 diabetes (T2D).Design, Setting, and Participants This target trial emulation study used electronic… Continue reading GLP-1RA and SGLT2i Medications for Type 2 #Diabetes and #Alzheimer Disease and Related Dementias
Effect of #sotagliflozin on major adverse cardiovascular events: a prespecified secondary analysis of the SCORED randomised trial
Sodium–glucose co-transporter (SGLT)-2 inhibitors have shown consistent benefit in improving heart failure-related outcomes but not ischaemic cardiovascular events such as myocardial infarction or stroke. We assessed if the dual SGLT1/2 inhibitor sotagliflozin improves ischaemic outcomes.MethodsWe did a prespecified secondary analysis of the SCORED trial, which was a double-blind, placebo-controlled, randomised clinical trial enrolling patients (aged… Continue reading Effect of #sotagliflozin on major adverse cardiovascular events: a prespecified secondary analysis of the SCORED randomised trial
Age and Sex Differences in Efficacy of Treatments for Type 2 #DiabetesA Network Meta-Analysis
Question Does the efficacy of sodium-glucose cotransporter 2 inhibitors, glucagon-like peptide-1 receptor agonists, and dipeptidyl peptidase 4 inhibitors vary by age and sex among individuals with type 2 diabetes?Findings In this systematic review and network meta-analysis of 601 eligible trials (including 103 trials with individual participant data), there was a greater reduction in the risk… Continue reading Age and Sex Differences in Efficacy of Treatments for Type 2 #DiabetesA Network Meta-Analysis
#Sugar-sweetened beverage intake, gut #microbiota, circulating metabolites, and #diabetes risk in Hispanic Community Health Study/Study of Latinos
Highlights• Sugar-sweetened beverage intake was associated with nine gut bacteria abundances• These bacteria were correlated with aromatic and branched-chain amino acid metabolites• These bacteria were correlated with glycerophospholipids• These gut microbial metabolites were associated with diabetes risk SummaryNo population-based studies examined gut microbiota and related metabolites associated with sugar-sweetened beverage (SSB) intake among US adults.… Continue reading #Sugar-sweetened beverage intake, gut #microbiota, circulating metabolites, and #diabetes risk in Hispanic Community Health Study/Study of Latinos
#Dapagliflozin plus calorie restriction for remission of type 2 #diabetes: multicentre, double blind, randomised, placebo controlled trial
Objective To assess the effect of dapagliflozin plus calorie restriction on remission of type 2 diabetes.Design Multicentre, double blind, randomised, placebo controlled trial.Setting 16 centres in mainland China from 12 June 2020 to 31 January 2023.Participants 328 patients with type 2 diabetes aged 20-70 years, with body mass index >25 and diabetes duration of <6… Continue reading #Dapagliflozin plus calorie restriction for remission of type 2 #diabetes: multicentre, double blind, randomised, placebo controlled trial
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