Yue, Luo, and colleagues discovered that adenosine signalling is the common underlying mechanism of rapid acting antidepressant therapies, unifying the effects of ketamine, ECT and acute intermittent hypoxia. They use genetically encoded sensors, along with extensive mechanistic dissection, to show that all three induce adenosine surges in mood-regulatory circuits via A1 and A2A receptor activation.… Continue reading #Adenosine as the metabolic common path of rapid #antidepressant action: The #coffee paradox
Tag: coffee
Caffeinated Coffee Consumption or Abstinence to Reduce Atrial FibrillationThe DECAF Randomized Clinical Trial
Key PointsQuestion Does consumption of caffeinated coffee have a beneficial, detrimental, or neutral effect on the risk of recurrent atrial fibrillation (AF) episodes?Findings In this multicenter randomized clinical trial including 200 patients with persistent AF undergoing cardioversion, the risk of recurrent AF was significantly lower in the group allocated to coffee consumption (47%) compared with… Continue reading Caffeinated Coffee Consumption or Abstinence to Reduce Atrial FibrillationThe DECAF Randomized Clinical Trial
Relative associations of #coffee, #tea, and plain #water with all-cause and cause-specific #mortality: a prospective cohort study
Previous studies have highlighted the health benefits of coffee and tea, but they only focused on the comparisons between different consumptions. Consequently, the association estimate lacked a clear interpretation, as the substitution of beverages and distribution of doses were not explicitly prescribed. We focused on the “relative association” to ascertain the optimal consumption strategy (including… Continue reading Relative associations of #coffee, #tea, and plain #water with all-cause and cause-specific #mortality: a prospective cohort study
#Coffee for the #liver: a mechanistic approach
The liver, which is essential for metabolism and detoxification, is vulnerable to various damaging factors, including viral infections, excessive alcohol consumption, and a diet high in fat and sugar. Coffee, one of the most widely consumed beverages worldwide, is valued not only for its flavor and aroma but also for its potential health benefits. In… Continue reading #Coffee for the #liver: a mechanistic approach
#Coffee ’s Impact on #Health and #Well-Being
AbstractCoffee is one of the most widely consumed beverages globally, with over 60% of Americans drinking it daily. This review examines coffee’s multifaceted impact on health and well-being, drawing on decades of research. Overall, the consensus is that moderate coffee intake is more beneficial than harmful across a wide range of health outcomes. Numerous large-scale,… Continue reading #Coffee ’s Impact on #Health and #Well-Being
Genetic Correlation and Mendelian Randomization Analyses Support Causal Relationships Between Instant #Coffee and Age-Related #Macular Degeneration
Coffee is a popular beverage, and previous cohort studies suggest it may reduce the risk of age-related macular degeneration (AMD). However, confounding factors in these studies necessitate further exploration of causal relationships using advanced methods. We obtained data on coffee consumption from genome-wide association studies (GWAS) and the latest AMD-related GWAS summary data from the… Continue reading Genetic Correlation and Mendelian Randomization Analyses Support Causal Relationships Between Instant #Coffee and Age-Related #Macular Degeneration
Coffee drinking timing and mortality in US adults
Background and Aims To identify the patterns of coffee drinking timing in the US population and evaluate their associations with all-cause and cause-specific mortality.Methods This study included 40 725 adults from the National Health and Nutrition Examination Survey 1999–2018 who had complete information on dietary data and 1463 adults from the Women’s and Men’s Lifestyle… Continue reading Coffee drinking timing and mortality in US adults
Impact of #coffee intake on human #aging: Epidemiology and cellular mechanisms
Highlights•The regular consumption of moderate doses of coffee attenuates all-cause mortality•Coffee intake attenuates age-associated diseases (cardiovascular, stroke, cancer)•Coffee and its main components (caffeine, chlorogenic acids) control stress adaptation•Coffee intake preserves the main biological mechanisms of aging AbstractThe conception of coffee consumption has undergone a profound modification, evolving from a noxious habit into a safe lifestyle… Continue reading Impact of #coffee intake on human #aging: Epidemiology and cellular mechanisms
#Coffee consumption is associated with intestinal #Lawsonibacter asaccharolyticus abundance and prevalence across multiple cohorts
Although diet is a substantial determinant of the human gut microbiome, the interplay between specific foods and microbial community structure remains poorly understood. Coffee is a habitually consumed beverage with established metabolic and health benefits. We previously found that coffee is, among >150 items, the food showing the highest correlation with microbiome components. Here we… Continue reading #Coffee consumption is associated with intestinal #Lawsonibacter asaccharolyticus abundance and prevalence across multiple cohorts
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