Dementia and hepatic encephalopathy (HE) are challenging to distinguish clinically. Undiagnosed cirrhosis in a patient with dementia can lead to missed opportunities to treat HE.Objective To examine the prevalence and risk factors of undiagnosed cirrhosis and therefore possible HE in veterans with dementia.Design, Setting, and Participants A retrospective cohort study was conducted between 2009 and 2019 using… Continue reading Undiagnosed #Cirrhosis and Hepatic #Encephalopathy in a National Cohort of Veterans With #Dementia
Tag: Cirrhosis
Balancing Act – Navigating Acid-Base Disorders in Cirrhosis Patients – A Physician’s Perspective
Cirrhosis, a complex and progressive liver disease, poses myriad challenges for physicians. Among its many complications, acid-base disorders often emerge as a perplexing aspect of patient care. Understanding the intricate interplay between liver dysfunction, acid-base balance, and the clinical implications thereof is pivotal for physicians managing cirrhosis patients. In this post, I embark on a… Continue reading Balancing Act – Navigating Acid-Base Disorders in Cirrhosis Patients – A Physician’s Perspective
Low Daily Step Count Is Associated With a High Risk of Hospital Admission and Death in Community-Dwelling Patients With Cirrhosis
Background & AimsDaily step count measures cardiorespiratory fitness and has been associated with clinical outcomes. However, its utility in patients with cirrhosis remains largely unexplored. We aimed to investigate the association between step count, frailty metrics, and clinical outcomes in cirrhosis.MethodsAll participants underwent frailty evaluation with the liver frailty index, 6-minute walk test, and gait… Continue reading Low Daily Step Count Is Associated With a High Risk of Hospital Admission and Death in Community-Dwelling Patients With Cirrhosis
Risk of fractures and subsequent mortality in alcohol-related cirrhosis: A nationwide population-based cohort study
Background and aimsAlcohol-related cirrhosis is linked to increased risk of fractures, but this has seldom been quantified nationally or compared against non-cirrhotic controls. Here, we determined the rate and risk of fractures and post-fracture mortality in patients with alcohol-related cirrhosis compared to individuals from the general population.MethodsIn this nationwide population-based cohort study, data were retrieved… Continue reading Risk of fractures and subsequent mortality in alcohol-related cirrhosis: A nationwide population-based cohort study
#Elastography is unable to exclude #cirrhosis after sustained virological response in #HCV-infected patients with advanced chronic liver disease
Liver fibrosis and transient elastography (TE) correlation in hepatitis C virus (HCV)-infected patients with compensated advanced chronic liver disease (cACLD) after sustained virological response (SVR) is unknown. AimsTo evaluate TE accuracy at identifying cirrhosis 3 years after HCV-eradication. MethodsProspective, multi-centric study including HCV-cACLD patients before direct-acting antivirals (DAA). Diagnostic accuracy of TE (area under ROC,… Continue reading #Elastography is unable to exclude #cirrhosis after sustained virological response in #HCV-infected patients with advanced chronic liver disease
Serum hepatitis B #core‐related antigen level stratifies risk of disease progression in chronic #hepatitis B patients with intermediate viral load
Patients with chronic hepatitis B virus (HBV) infection are at risk of developing liver disease. Serum hepatitis B core‐related antigen (HBcrAg) is a new biomarker for intrahepatic templates for HBV replication.. ..A total of 1673 treatment‐naïve, non‐cirrhotic patients with negative hepatitis B e antigen (HBeAg) and alanine aminotransferase (ALT) level <40 U/L at baseline were… Continue reading Serum hepatitis B #core‐related antigen level stratifies risk of disease progression in chronic #hepatitis B patients with intermediate viral load
GES: A validated simple score to predict the risk of #HCC in patients with #HCV‐GT4‐associated advanced liver fibrosis after oral antivirals
Hepatocellular carcinoma (HCC) risk persists after hepatitis C virus (HCV) eradication with direct‐acting antivirals (DAAs), particularly in patients with cirrhosis. Identifying those who are likely to develop HCC is a critical unmet medical need. Our aim is to develop a score that offers individualized patient HCC risk prediction.. ..In the derivation cohort, the median follow‐up… Continue reading GES: A validated simple score to predict the risk of #HCC in patients with #HCV‐GT4‐associated advanced liver fibrosis after oral antivirals
Natural history of acute #kidney disease in patients with #cirrhosis
In 2012, KDIGO group proposed new definitions for Acute Kidney Injury (AKI), Acute Kidney Disease (AKD) and Chronic Kidney Disease (CKD). According to the definition adapted by the International Club of Ascites (ICA), AKI has been extensively investigated in patients with cirrhosis. On the contrary, there are currently no data on the epidemiology and clinical… Continue reading Natural history of acute #kidney disease in patients with #cirrhosis
Hepatic decompensation in #cirrhotic patients receiving antiviral therapy for chronic #hepatitis B
It is unclear if anti-hepatitis B virus (HBV) treatment can eliminate incident hepatic decompensation. Here we report the incidence and predictors of hepatic decompensation among cirrhotic patients receiving antiviral therapy for chronic hepatitis B.. ..818 patients (mean age, 54.9 years; 519 male [63.4%]) were included in the final analysis. During a mean follow-up of 58.1… Continue reading Hepatic decompensation in #cirrhotic patients receiving antiviral therapy for chronic #hepatitis B
2 Medical News 