Caffeine has significant effects on neurovascular activity and behavior throughout the sleep–wake cycle. We used a minimally invasive microchip/video system to continuously record effects of caffeine in the drinking water of freely behaving mice. Chronic caffeine shifted both rest and active phases by up to 2 h relative to the light–dark cycle in a dose-dependent fashion.… Continue reading Effects of chronic #caffeine on patterns of #brain blood flow and behavior throughout the sleep–wake cycle in freely behaving mice
Tag: Brain
Deep Brain Stimulation: A Revolutionary Approach to Post-Stroke Rehabilitation
In recent years, the medical community has concentrated its efforts on developing innovative treatments to aid in post-stroke recovery. Among the … Deep Brain Stimulation: A Revolutionary Approach to Post-Stroke RehabilitationDeep Brain Stimulation: A Revolutionary Approach to Post-Stroke Rehabilitation
Visceral and Subcutaneous #Abdominal #Fat Predict #Brain Volume Loss at Midlife in 10,001 Individuals
AbstractAbdominal fat is increasingly linked to brain health. A total of 10,001 healthy participants were scanned on 1.5T MRI with a short whole-body MR imaging protocol. Deep learning with FastSurfer segmented 96 brain regions. Separate models segmented visceral and subcutaneous abdominal fat. Regression analyses of abdominal fat types and normalized brain volumes were evaluated, controlling… Continue reading Visceral and Subcutaneous #Abdominal #Fat Predict #Brain Volume Loss at Midlife in 10,001 Individuals
The Gut-Brain Axis: Unveiling the Microbiome’s Role in Cognitive Development and Brain Health
A Complex Communication Highway In the intricate network of the human body, a fascinating unsuspected connection is being unraveled—one that links the gut and the brain in ways we never imagined! This connection, known as the Gut-Brain Axis, is revealing a whole new dimension to the critical role played by the microbiome in the development… Continue reading The Gut-Brain Axis: Unveiling the Microbiome’s Role in Cognitive Development and Brain Health
Regional, circuit and network heterogeneity of #brain abnormalities in #psychiatric disorders
The substantial individual heterogeneity that characterizes people with mental illness is often ignored by classical case–control research, which relies on group mean comparisons. Here we present a comprehensive, multiscale characterization of the heterogeneity of gray matter volume (GMV) differences in 1,294 cases diagnosed with one of six conditions (attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder,… Continue reading Regional, circuit and network heterogeneity of #brain abnormalities in #psychiatric disorders
#IQ After Pediatric #Concussion
This study investigated IQ scores in pediatric concussion (ie, mild traumatic brain injury) versus orthopedic injury.METHODS:Children (N = 866; aged 8–16.99 years) were recruited for 2 prospective cohort studies from emergency departments at children’s hospitals (2 sites in the United States and 5 in Canada) ≤48 hours after sustaining a concussion or orthopedic injury. They completed… Continue reading #IQ After Pediatric #Concussion
The associations of glycosylated hemoglobin with grey matter volume and depression: Investigating mediating role of grey matter volume
Highlights•This is the first study to investigate the mediation effect of GMV on the association between HbA1c and depression.•Hba1c was negatively associated with GMV, and that association were stronger in prediabetic participants.•Cerebral GMV plays a mediating role on the association “HbA1c-depression”, with a proportions of 6.82%.•Effective control of glycemia can potentially prevent brain abnormality and… Continue reading The associations of glycosylated hemoglobin with grey matter volume and depression: Investigating mediating role of grey matter volume
Association of Early Adulthood Hypertension and Blood Pressure Change With Late-Life Neuroimaging Biomarkers
The association between hypertension developed before midlife and late-life brain health is understudied and, because of the cardioprotective benefits of estrogen before menopause, may differ by sex. Objective To assess the association of early adulthood hypertension and blood pressure (BP) change with late-life neuroimaging biomarkers and examine potential sex differences. Design, Setting, and Participants This cohort study… Continue reading Association of Early Adulthood Hypertension and Blood Pressure Change With Late-Life Neuroimaging Biomarkers
Genetic analyses identify brain structures related to cognitive impairment associated with elevated blood pressure
Background and aimsObservational studies have linked elevated blood pressure (BP) to impaired cognitive function. However, the functional and structural changes in the brain that mediate the relationship between BP elevation and cognitive impairment remain unknown. Using observational and genetic data from large consortia, this study aimed to identify brain structures potentially associated with BP values… Continue reading Genetic analyses identify brain structures related to cognitive impairment associated with elevated blood pressure
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