The gut microbiome affects the inflammatory environment through effects on T-cells, which influence the production of immune mediators and inflammatory cytokines that stimulate osteoclastogenesis and bone loss in mice. However, there are few large human studies of the gut microbiome and skeletal health. We investigated the association between the human gut microbiome and high resolution… Continue reading A two-cohort study on the association between the gut #microbiota and #bone density, microarchitecture, and strength
Tag: bone-density
Association of Bone Mineral Density and Dementia: The Rotterdam Study
Background & Objective: Low bone mineral density and dementia commonly co-occur in the elderly, with bone loss accelerating in dementia patients due to physical inactivity and poor nutrition. However, uncertainty persists over the extent to which bone loss already exists prior to the onset of dementia. Therefore, we investigated how dementia risk was affected by… Continue reading Association of Bone Mineral Density and Dementia: The Rotterdam Study
Air pollution and decreased bone mineral density among Women’s Health Initiative participants
BackgroundOsteoporosis heavily affects postmenopausal women and is influenced by environmental exposures. Determining the impact of criteria air pollutants and their mixtures on bone mineral density (BMD) in postmenopausal women is an urgent priority.MethodsWe conducted a prospective observational study using data from the ethnically diverse Women's Health Initiative Study (WHI) (enrollment, September 1994–December 1998; data analysis,… Continue reading Air pollution and decreased bone mineral density among Women’s Health Initiative participants
High blood pressure may accelerate bone aging
A new study in mice, presented at an American Heart Association meeting, suggests high blood pressure may cause bones to age fasterResearch Highlights:A new study in mice found that hypertension may be linked to significant bone loss.Bone quality in young mice with high blood pressure was similar to the bones of older mice without high… Continue reading High blood pressure may accelerate bone aging
SARS-CoV-2 infection induces inflammatory bone loss in golden Syrian hamsters
Extrapulmonary complications of different organ systems have been increasingly recognized in patients with severe or chronic Coronavirus Disease 2019 (COVID-19). However, limited information on the skeletal complications of COVID-19 is known, even though inflammatory diseases of the respiratory tract have been known to perturb bone metabolism and cause pathological bone loss. In this study, we… Continue reading SARS-CoV-2 infection induces inflammatory bone loss in golden Syrian hamsters
Age-related changes in #bone density, microarchitecture and strength in postmenopausal Black and White women: SWAN Longitudinal HR-pQCT Study
Higher fracture risk in White versus Black women is partly explained by lower BMD and worse bone microarchitecture in White women. However, whether rates of decline in bone density, microarchitecture and strength differ between postmenopausal Black and White women is unknown. Further, factors that influence rates of age-related bone microarchitecture deterioration remain ill-defined. Thus, over… Continue reading Age-related changes in #bone density, microarchitecture and strength in postmenopausal Black and White women: SWAN Longitudinal HR-pQCT Study
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