Purpose: Patients with acute coronary syndrome (#ACS ) on ticagrelor-based dual antiplatelet therapy (#DAPT ) have an increased risk of gastrointestinal (GI) bleeding. However, evidence supporting the protective role of proton pump inhibitors against DAPT-induced gastric mucosal injury remains limited.Materials and methods: This was a single-center, prospective, open-label, observational trial enrolling patients with ACS who… Continue reading Evaluation of Rabeprazole for Gastrointestinal Protection in Acute Coronary Syndrome Patients Treated with Aspirin and Ticagrelor: A Pilot Study
Tag: AMI
Electroacupuncture for slow flow/no-reflow in patients with acute myocardial infarction undergoing percutaneous coronary intervention: a pilot randomized controlled trial
Background: Slow flow/no-reflow (SF-NR) complicates up to 44% of percutaneous #coronary interventions ( #PCI) for acute myocardial infarction (#AMI), worsening prognosis. Electroacupuncture (EA) may mitigate SF-NR, but clinical evidence is limited.Objective: This trial was designed to assess the feasibility and effectiveness of intraoperative EA in reducing SF-NR during PCI for AMI patients.Design setting and participants… Continue reading Electroacupuncture for slow flow/no-reflow in patients with acute myocardial infarction undergoing percutaneous coronary intervention: a pilot randomized controlled trial
#Beta-blockers after myocardial #infarction: effects according to #sex in the REBOOT trial
Background and AimsRecent trials have challenged the guideline recommendation of beta-blockers for post-myocardial infarction (MI) patients without reduced left ventricular ejection fraction (LVEF). Whether these recent findings apply equally to women and men remains unknown.MethodsUsing data from REBOOT (tREatment with Beta-blockers after myOcardial infarction withOut reduced ejection fracTion), the largest randomized trial evaluating the effect… Continue reading #Beta-blockers after myocardial #infarction: effects according to #sex in the REBOOT trial
Restrictive versus Liberal #Transfusion in Myocardial #Infarction — A Patient-Level Meta-Analysis
BackgroundClinical guidelines have concluded that there are insufficient data to provide recommendations for the hemoglobin threshold for the use of red cell transfusion in patients with acute myocardial infarction (MI) and anemia. After the recent publication of the Myocardial Infarction and Transfusion (MINT) trial, we performed an individual patient-level data meta-analysis to evaluate the effect… Continue reading Restrictive versus Liberal #Transfusion in Myocardial #Infarction — A Patient-Level Meta-Analysis
Association of #SARS-CoV-2 immunoserology and #vaccination status with #myocardial infarction severity and outcome
Background: The COVID-19 pandemic adversely affected the severity and prognosis of patients with acute myocardial infarction (MI) caused by atherothrombosis (type 1 MI). The effect, if any, of COVID-19 vaccination and natural SARS-CoV2 serologic immunity in these patients is unclear. Our aim was to analyze the association between the severity and outcome of patients with type… Continue reading Association of #SARS-CoV-2 immunoserology and #vaccination status with #myocardial infarction severity and outcome
#Beta-Blockers after Myocardial #Infarction and Preserved #Ejection Fraction
BACKGROUNDMost trials that have shown a benefit of beta-blocker treatment after myocardial infarction included patients with large myocardial infarctions and were conducted in an era before modern biomarker-based diagnosis of myocardial infarction and treatment with percutaneous coronary intervention, antithrombotic agents, high-intensity statins, and renin–angiotensin–aldosterone system antagonists.METHODSIn a parallel-group, open-label trial performed at 45 centers in… Continue reading #Beta-Blockers after Myocardial #Infarction and Preserved #Ejection Fraction
Association Between Acute Myocardial Infarction and Cognition
Importance The magnitude of cognitive change after incident myocardial infarction (MI) is unclear.Objective To assess whether incident MI is associated with changes in cognitive function after adjusting for pre-MI cognitive trajectories.Design, Setting, and Participants This cohort study included adults without MI, dementia, or stroke and with complete covariates from the following US population-based cohort studies conducted from 1971… Continue reading Association Between Acute Myocardial Infarction and Cognition
Association of beta-blockers beyond 1 year after myocardial infarction and cardiovascular outcomes
Objective Beta-blockers (BB) are an established treatment following myocardial infarction (MI). However, there is uncertainty as to whether BB beyond the first year of MI have a role in patients without heart failure or left ventricular systolic dysfunction (LVSD).Methods A nationwide cohort study was conducted including 43 618 patients with MI between 2005 and 2016 in the Swedish… Continue reading Association of beta-blockers beyond 1 year after myocardial infarction and cardiovascular outcomes
Subclinical Coronary Atherosclerosis and Risk for Myocardial Infarction in a Danish CohortA Prospective Observational Cohort Study
Background:Coronary atherosclerosis may develop at an early age and remain latent for many years.Objective:To define characteristics of subclinical coronary atherosclerosis associated with the development of myocardial infarction.Design:Prospective observational cohort study.Setting:Copenhagen General Population Study, Denmark.Participants:9533 asymptomatic persons aged 40 years or older without known ischemic heart disease.Measurements:Subclinical coronary atherosclerosis was assessed with coronary computed tomography angiography… Continue reading Subclinical Coronary Atherosclerosis and Risk for Myocardial Infarction in a Danish CohortA Prospective Observational Cohort Study
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